The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two‐hybrid system, is disrupted by cyclosporin A and FK506

Chaudhuri, Bhabatosh; Hämmerle, Marcus; Fürst, Peter

doi:10.1016/0014-5793(94)01365-8

The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two‐hybrid system, is disrupted by cyclosporin A and FK506

The Ca 2+ ‐calmodulin dependent protein phosphatase, calcineurin, is thought to mediate the action of the two immuno‐suppressants, cyclosporin A (CsA) and FK506. Calcineurin from all species consists of a catalytic A subunit and a regulatory peptide B, which plays an essential role in catalysis. …