The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hypoxia and platelet‐derived growth factor‐BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells
Abstract
Vascular endothelial growth factor (VEGF) mRNA expression was analysed in rabbit vascular smooth muscle cells following exposure to hypoxia and platelet‐derived growth factor‐BB (PDGF‐BB). Hypoxia potently upregulated VEGF mRNA steady‐state levels in a time‐ and concentration‐dependent manner reaching a maximum level (∼30‐fold increase) after 12–24 h at 0% 0 2. In contrast, PDGF‐BB caused a modest increase in VEGF expression. However, the combination of PDGF‐BB and a threshold hypoxic stimulus (2.5% O 2 for 4 h) had a marked synergistic effect. Synergy between hypoxia and PDGF‐BB was selective for VEGF expression as hypoxia had no effect on the PDGF‐induced upregulation of the proto‐oncogene c‐myc. These results raise the possibility that hypoxia and PDGF‐BB may act in concert to induce VEGF expression in the arterial wall during the development of atherosclerosis.
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Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., & Alitalo, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37365-9 · Cited by 694
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Clauss, M., Weich, H., Breier, G., Knies, U., Röckl, W., Waltenberger, J., & Risau, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17629 · Cited by 836
Self-citationStavri, G. T., Zachary, I. C., Baskerville, P. A., Martin, J. F., & Erusalimsky, J. D. (1995) · Circulation · doi:10.1161/01.cir.92.1.11 · Cited by 395
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D'Ippolito, G., Diabira, S., Howard, G. A., Roos, B. A., & Schiller, P. C. (2006) · Bone · doi:10.1016/j.bone.2006.02.061 · Cited by 388
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Schaper, W., & Ito, W. D. (1996) · Circulation Research · doi:10.1161/01.res.79.5.911 · Cited by 371
Metadata
- Authors
- Stavri, G. T., Hong, Y., Zachary, I. C., Breier, G., Baskerville, P. A., Ylä-Herttuala, S., Risau, W., Martin, J. F., & Erusalimsky, J. D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-01-30
- Volume
- 358
- Issue
- 3
- Pages
- 311-315
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2023997632
- Cited by
- 163
- References
- 2
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stavri, G. T., Hong, Y., Zachary, I. C., Breier, G., Baskerville, P. A., Ylä-Herttuala, S., Risau, W., Martin, J. F., & Erusalimsky, J. D. (1995). Hypoxia and platelet‐derived growth factor‐BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells. FEBS Letters. https://doi.org/10.1016/0014-5793(94)01458-d
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
