The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Basic Fibroblast Growth Factor Upregulates the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells: Synergistic Interaction With Hypoxia
Abstract
Background Vascular endothelial growth factor (VEGF) is a hypoxia-inducible direct angiogenic factor. Upregulation of VEGF is thought to mediate many of the angiogenic effects of growth factors that are not direct endothelial cell mitogens. Like VEGF, basic fibroblast growth factor (bFGF) is considered to induce angiogenesis by a direct effect on endothelial cells. This study investigated the possibility that bFGF may also act indirectly by regulating VEGF expression in vascular smooth muscle cells (VSMCs). Methods and Results Incubation of confluent and quiescent cultures of rabbit VSMCs with bFGF caused a time- and concentration-dependent increase in steady-state levels of VEGF mRNA, as analyzed by Northern blot hybridization. Exposure of VSMCs to a threshold hypoxic stimulus (2.5% O 2 ) caused a modest increase in VEGF mRNA levels. However, the combination of 2.5% O 2 with bFGF had a marked synergistic effect. This effect was specific for VEGF as hypoxia did not enhance bFGF-induced expression of the proto-oncogene c- myc . Synergistic upregulation of VEGF mRNA expression also was observed between hypoxia and TGF-β 1 . Conclusions These results suggest that bFGF may promote angiogenesis both by a direct effect on endothelial cells and also indirectly by the upregulation of VEGF in VSMCs. The synergy demonstrated between hypoxia and either bFGF or TGF-β 1 suggests that multiple diverse stimuli may interact via the upregulation of VEGF expression in VSMCs to amplify the angiogenic response.
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Cites
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PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Mechanisms of normal and tumor-derived angiogenesis
Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809
Age-Dependent Impairment of Angiogenesis
Rivard, A., Fabre, J.-E., Silver, M., Chen, D., Murohara, T., Kearney, M., Magner, M., Asahara, T., & Isner, J. M. (1999) · Circulation · doi:10.1161/01.cir.99.1.111 · Cited by 771
Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Nosrati, H., Aramideh Khouy, R., Nosrati, A., Khodaei, M., Banitalebi-Dehkordi, M., Ashrafi-Dehkordi, K., Sanami, S., & Alizadeh, Z. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00755-7 · Cited by 720
Murohara, T., Horowitz, J. R., Silver, M., Tsurumi, Y., Chen, D., Sullivan, A., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.97.1.99 · Cited by 517
Metadata
- Authors
- Stavri, G. T., Zachary, I. C., Baskerville, P. A., Martin, J. F., & Erusalimsky, J. D.
- Venue
- Circulation
- Published
- 1995-07
- Volume
- 92
- Issue
- 1
- Pages
- 11-14
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1975250411
- Cited by
- 395
- References
- 27
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Basic Fibroblast Growth Factor Upregulates the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells: Synergistic Interaction With Hypoxia. https://app.cochat.ai/papers/10.1161/01.cir.92.1.11
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- Stavri, G. T., Zachary, I. C., Baskerville, P. A., Martin, J. F., & Erusalimsky, J. D. (1995). Basic Fibroblast Growth Factor Upregulates the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells: Synergistic Interaction With Hypoxia. Circulation. https://doi.org/10.1161/01.cir.92.1.11
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