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Cytochrome oxidase evolved by tinkering with denitrification enzymes
Open accessAbstract
The cytochrome bc complex which is encoded by the fixNOPQ operon in Bradyrhizobiumjaponicum, is the most distant member of the haem‐copper cytochrome oxidase family. We have found that its major subunit, FixN, is homologous to the NorB subunit of nitric oxide reductase in a purple bacterium. A second evolutionary link between cytochrome oxidases and denitrification enzymes is the presence of a similar binuclear copper site in cytochrome aa 3 (the mitochondrial oxidase) and nitrous oxide reductase. This centre was probably acquired by a primitive FixN‐type oxidase, leading to the evolution of the mitochondrial‐type oxidase. These links suggest that the oxygen‐reducing respiratory chain developed from the anaerobic, denitrifying respiratory system.
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Kasting, J. F. (1993) · Science · doi:10.1126/science.11536547 · Cited by 1,374
Cited by
Nitric oxide and mitochondrial respiration
Brown, G. C. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00025-0 · Cited by 702
Berks, B. C., Ferguson, S. J., Moir, J. W. B., & Richardson, D. J. (1995) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(95)00092-5 · Cited by 596
Richardson, D., Felgate, H., Watmough, N., Thomson, A., & Baggs, E. (2009) · Trends in Biotechnology · doi:10.1016/j.tibtech.2009.03.009 · Cited by 549
Richardson, D. J. (2000) · Microbiology · doi:10.1099/00221287-146-3-551 · Cited by 544
Comparative Genomics of Emerging Human Ehrlichiosis Agents
Dunning Hotopp, J. C., Lin, M., Madupu, R., Crabtree, J., Angiuoli, S. V., Eisen, J., Seshadri, R., Ren, Q., Wu, M., Utterback, T. R., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020021 · Cited by 488
Metadata
- Authors
- Saraste, M., & Castresana, J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-03-14
- Volume
- 341
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2059539744
- Cited by
- 244
- References
- 1
- FWCI
- 15.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Saraste, M., & Castresana, J. (1994). Cytochrome oxidase evolved by tinkering with denitrification enzymes. FEBS Letters. https://doi.org/10.1016/0014-5793(94)80228-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
