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Cited by 488

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Comparative Genomics of Emerging Human Ehrlichiosis Agents

Open access
Dunning Hotopp, Julie C., Lin, Mingqun, Madupu, Ramana, Crabtree, Jonathan, Angiuoli, Samuel V, Eisen, Jonathan, Seshadri, Rekha, Ren, Qinghu, Wu, Martin, Utterback, Teresa R, Smith, Shannon, Lewis, Matthew, Khouri, Hoda, Zhang, Chunbin, Niu, Hua, Lin, Quan, Ohashi, Norio, Zhi, Ning, Nelson, William, Brinkac, Lauren M, Dodson, Robert J, Rosovitz, M. J, Sundaram, Jaideep, Daugherty, Sean C, Davidsen, Tanja, Durkin, Anthony S, Gwinn, Michelle, Haft, Daniel H, Selengut, Jeremy D, Sullivan, Steven A, Zafar, Nikhat, Zhou, Liwei, Benahmed, Faiza, Forberger, Heather, Halpin, Rebecca, Mulligan, Stephanie, Robinson, Jeffrey, White, Owen, Rikihisa, Yasuko, Tettelin, Hervé·2006·PLoS Genetics
DOI 10.1371/journal.pgen.0020021
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Abstract

Anaplasma (formerly Ehrlichia) phagocytophilum, Ehrlichia chaffeensis, and Neorickettsia (formerly Ehrlichia) sennetsu are intracellular vector-borne pathogens that cause human ehrlichiosis, an emerging infectious disease. We present the complete genome sequences of these organisms along with comparisons to other organisms in the Rickettsiales order. Ehrlichia spp. and Anaplasma spp. display a unique large expansion of immunodominant outer membrane proteins facilitating antigenic variation. All Rickettsiales have a diminished ability to synthesize amino acids compared to their closest free-living relatives. Unlike members of the Rickettsiaceae family, these pathogenic Anaplasmataceae are capable of making all major vitamins, cofactors, and nucleotides, which could confer a beneficial role in the invertebrate vector or the vertebrate host. Further analysis identified proteins potentially involved in vacuole confinement of the Anaplasmataceae, a life cycle involving a hematophagous vector, vertebrate pathogenesis, human pathogenesis, and lack of transovarial transmission. These discoveries provide significant insights into the biology of these obligate intracellular pathogens.

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Show all 69 references

Research works printed but not linked: 19

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Metadata

Authors
Dunning Hotopp, J. C., Lin, M., Madupu, R., Crabtree, J., Angiuoli, S. V., Eisen, J., Seshadri, R., Ren, Q., Wu, M., Utterback, T. R., Smith, S., Lewis, M., Khouri, H., Zhang, C., Niu, H., Lin, Q., Ohashi, N., Zhi, N., Nelson, W., Brinkac, L. M., Dodson, R. J., Rosovitz, M. J., Sundaram, J., Daugherty, S. C., Davidsen, T., Durkin, A. S., Gwinn, M., Haft, D. H., Selengut, J. D., Sullivan, S. A., Zafar, N., Zhou, L., Benahmed, F., Forberger, H., Halpin, R., Mulligan, S., Robinson, J., White, O., Rikihisa, Y., & Tettelin, H.
Venue
PLoS Genetics
Publisher
Public Library of Science (PLoS)
Published
2006-02-17
Volume
2
Issue
2
Pages
e21
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
DOI
10.1371/journal.pgen.0020021
OpenAlex
W2061880687
Cited by
488
References
69
FWCI
24.99
Type
journal article
Language
en
Update notices
correction (2006-12-29)
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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CoChat. (2026). Citation check: Comparative Genomics of Emerging Human Ehrlichiosis Agents. https://app.cochat.ai/papers/10.1371/journal.pgen.0020021
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Dunning Hotopp, J. C., Lin, M., Madupu, R., Crabtree, J., Angiuoli, S. V., Eisen, J., Seshadri, R., Ren, Q., Wu, M., Utterback, T. R., Smith, S., Lewis, M., Khouri, H., Zhang, C., Niu, H., Lin, Q., Ohashi, N., Zhi, N., Nelson, W., . . . Tettelin, H. (2006). Comparative Genomics of Emerging Human Ehrlichiosis Agents. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0020021

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