The DOI matches its Crossref record.
Expression of α2‐macroglobulin receptor/low density lipoprotein receptor‐related protein is increased in reactive and neoplastic glial cells
Abstract
α 2‐Macroglobulin receptor/low density lipoprotein receptor‐related protein (α 2 M‐R/LRP) is a multi‐functional cell‐surface receptor that has been implicated in diverse physiologic processes. In normal human brain, α 2 M‐R/LRP is expressed principally by pyramidal neurons with localization to cell bodies and proximal processes. By contrast, α 2 M‐R/LRP is not present in either the cell bodies or processes of most normal macroglia (including astrocytes). In this investigation, we studied the expression of α 2 M‐R/LRP in the brain, following tissue injury or neoplastic transformation, by immunohistochemistry. Significantly increased α 2 M‐R/LRP immunoreactivity was identified in reactive astrocytes, indicating that expression of this receptor is regulated in vivo in response to brain injury. α 2 M‐R/LRP immunoreactivity was also detected in glial cell tumors; this finding is novel since malignant transformation is typically thought to turn off expression of this receptor.
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The expression and function of LRP-1 correlates with glioblastoma cell invasion.
“In addition, the expression and function of receptor low-density lipoprotein receptor-related protein-1 (LRP-1) was shown to correlate with glioblastoma cell invasion [15,16,17].”
From MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells (2022) · cites this paper as [16]
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Research works printed but not linked: 28
- 10.1073/pnas.88.19.8342 · DOI · Paper page
- 10.1016/S0021-9258(18)42072-8 · DOI
- 10.1073/pnas.89.16.7422 · DOI
- 10.1073/pnas.89.16.7427 · DOI
- 10.1172/JCI114998 · DOI
- 10.1016/S0021-9258(18)42291-0 · DOI
- 10.1002/j.1460-2075.1988.tb03306.x · DOI
- 10.1002/j.1460-2075.1990.tb08301.x · DOI
- 10.1097/00041433-199104000-00002 · DOI
- 10.1007/BF00353892 · DOI
- Wolf B.B., 1992, Am. J. Pathol., 141, 37
- 10.1016/S0021-9258(17)45392-0 · DOI
- 10.1172/JCI116283 · DOI
- 10.1016/S0021-9258(18)50573-1 · DOI
- Gonias S.L., 1994, Ann. N.Y. Acad. Sci.
- 10.1007/978-3-642-84988-6 · DOI
- 10.1016/0014-4827(90)90185-D · DOI
- 10.1042/bj2930443 · DOI
- 10.1083/jcb.109.6.3411 · DOI
- 10.1016/0006-8993(86)90029-6 · DOI
- 10.1007/BF02969484 · DOI
- 10.1016/0046-8177(93)90156-B · DOI
- 10.1016/0012-1606(86)90231-9 · DOI
- 10.1016/0167-5699(93)90221-6 · DOI
- 10.1016/0197-4580(93)90006-W · DOI
- 10.1002/jcp.1041390221 · DOI
- 10.1016/S0021-9258(17)45368-3 · DOI
- Friedberg E., 1991, J. Neuropathol. Exp. Neurol., 50, 293
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Metadata
- Authors
- Lopes, M. B. S., Bogaev, C. A., Gonias, S. L., & VandenBerg, S. R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-02-07
- Volume
- 338
- Issue
- 3
- Pages
- 301-305
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 64
- References
- 0
- Language
- en
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