Cited by 137Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex

Thal, D. R., Schultz, Christian, Dehghani, Faramarz, Yamaguchi, Haruyasu, Braak, Heiko, Braak, Eva·2000·Acta Neuropathologica

Abstract

The deposition of the amyloid beta-protein (Abeta) is a pathological hallmark of Alzheimer's disease (AD). Abeta is a peptide consisting of 39-43 amino acids and is derived by beta- and gamma-secretase cleavage from the Abeta protein precursor (AbetaPP). An N-terminal-truncated form of Abeta can occur following alpha- and gamma-secretase cleavage of AbetaPP. Fleecy amyloid is a recently identified distinct type of Abeta deposits occurring in the internal layers (pri-alpha, pri-beta and pri-gamma) of the human entorhinal cortex. Fleecy amyloid consists exclusively of N-terminal-truncated Abeta and is a transient form of Abeta deposits, which disappears in late-stage beta-amyloidosis. In this study, the entorhinal cortex of 15 cases with AD-related pathology was used to examine astrocytes in the vicinity of N-terminal-truncated Abeta in fleecy amyloid of the layers pri-alpha, pri-beta, and pri-gamma in comparison to astrocytes in the vicinity of full-length Abeta in layers pre-beta and pre-gamma. Immunohistochemistry was performed with antibodies directed against AbetaPP, Abeta40, Abeta42, APbeta17-24, Abeta1-17 and Abeta8-17 as well as by double-labeling with antibodies directed against Abeta17-24, Abeta42, and glial fibrillary acid protein (GFAP). A large number of GFAP-positive astrocytes containing N-terminal-truncated Abeta fragments appeared in the vicinity of N-terminal-truncated Abeta, whereas Abeta-containing astrocytes were rarely seen in the vicinity of full-length A…

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Crossref · 10.1007/s004010000242

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Authors
Thal, D. R., Schultz, C., Dehghani, F., Yamaguchi, H., Braak, H., & Braak, E.
Affiliations
  • Goethe University Frankfurt (DE)
  • Gunma University (JP)
Venue
Acta Neuropathologica
Published
2000-12-18
Volume
100
Issue
6
Pages
608-617
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W2087697089
Cited by
136
References
32
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 16 · 2022: 6 · 2021: 12 · 2020: 9 · 2019: 1 · 2018: 5 · 2017: 11 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 5
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Bundesministerium für Bildung und Forschung
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
amyloid-beta, entorhinal cortex, astrocytes, Alzheimer's disease, amyloid precursor protein, amyloid clearance, extracellular amyloid deposition, gamma-secretase, beta-secretase, glial fibrillary acidic protein
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Astrocytes, Female, Humans, Male, Middle Aged, Peptide Fragments, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Protein Structure, Tertiary, Entorhinal Cortex, Plaque, Amyloid

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