The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Human μ opiate receptor: cDNA and genomic clones, pharmacologic characterization and chromosomal assignment
Open accessAbstract
A human μ opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat μ opiate receptor cDNA. The human μ opiate receptor (hμOR1) shares 95% amino acid identity with the rat sequence. The expressed μOR1 recognizes tested opiate drugs and opioid peptides in a sodium‐ and GTP‐sensitive fashion with affinities virtually identical to those displayed by the rat μ opiate receptor. Effects on cyclic AMP are similar to those noted for the rat μ opiate receptor. An 18 kb genomic clone hybridizing with the hμOR1 cDNA contains 63 and 489 bp exonic sequences flanked by splice donor/acceptor sequences. Analysis of hybridization to DNA prepared from human rodent hybrid cell lines and chromosomal in situ hybridization studies indicate localization to 6q24–25. An Msp I polymorphism, producing a 3.7 kb band, may prove useful in assessing this gene's involvement in neuropsychiatric disorders involving opiatergic systems.
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A high-coverage genome sequence from an archaic denisovan individual
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The biological, social and clinical bases of drug addiction: commentary and debate
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Metadata
- Authors
- Wang, J.-B., Johnson, P. S., Persico, A. M., Hawkins, A. L., Griffin, C. A., & Uhl, G. R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-01-31
- Volume
- 338
- Issue
- 2
- Pages
- 217-222
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1570074927
- Cited by
- 290
- References
- 40
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, J.-B., Johnson, P. S., Persico, A. M., Hawkins, A. L., Griffin, C. A., & Uhl, G. R. (1994). Human μ opiate receptor: cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Letters. https://doi.org/10.1016/0014-5793(94)80368-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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