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Immunoreactive adrenomedullin in human plasma
Open accessAbstract
A specific and sensitive radioimmunoassay for adrenomedullin has been developed. Half‐maximal inhibition of binding of radioiodinated adrenomedullin was observed at 4 tool/tube. The radioimmunoassay recognized the entire adrenomedullin molecule and has little crossreactivity with adrenomedullin fragment peptides. Adrenomedullin‐like immunoreactivity was found to circulate in human plasma at considerable concentration (3.3 ± 0.39 ). The immunoreactivity of adrenomedullin was eluted at almost the same position as synthetic adrenomedullin on gel‐filtration chromatography and reverse‐phase high‐performance liquid chromatography, suggesting that circulating adrenomedullin recognized by the present radioimmunoassay is identical or very similar to authentic adrenomedullin. Plasma immunoreactive adrenomedullin significantly increased in patients with hypertension, with a progressive rise proportionate to disease severity.
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Cited by
Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue
Hosoda, H., Kojima, M., Matsuo, H., & Kangawa, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4039 · Cited by 929
Self-citationVascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Brain, S. D., & Grant, A. D. (2004) · Physiological Reviews · doi:10.1152/physrev.00037.2003 · Cited by 765
VAN ROSSUM, D., HANISCH, U.-K., & QUIRION, R. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00023-1 · Cited by 516
Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
Shindo, T., Kurihara, Y., Nishimatsu, H., Moriyama, N., Kakoki, M., Wang, Y., Imai, Y., Ebihara, A., Kuwaki, T., Ju, K.-H., et al. (2001) · Circulation · doi:10.1161/hc4101.097111 · Cited by 297
Self-citationAdrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo
Cornish, J., Callon, K. E., Coy, D. H., Jiang, N.-Y., Xiao, L., Cooper, G. J. S., & Reid, I. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1113 · Cited by 96
Metadata
- Authors
- Kitamura, K., Ichiki, Y., Tanaka, M., Kawamoto, M., Emura, J., Sakakibara, S., Kangawa, K., Matsuo, H., & Eto, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-03-21
- Volume
- 341
- Issue
- 2-3
- Pages
- 288-290
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2167075086
- Cited by
- 281
- References
- 0
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kitamura, K., Ichiki, Y., Tanaka, M., Kawamoto, M., Emura, J., Sakakibara, S., Kangawa, K., Matsuo, H., & Eto, T. (1994). Immunoreactive adrenomedullin in human plasma. FEBS Letters. https://doi.org/10.1016/0014-5793(94)80474-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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