The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
Open accessAbstract
Background Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice. Methods and Results Targeted null mutation of the AM gene is lethal in utero: the mortality rate among AM −/− embryos was >80% at E13.5. The most apparent abnormality in surviving AM −/− embryos at E13.5 to E14.0 was severe hemorrhage, readily observable under the skin and in visceral organs. Hemorrhage was not detectable at E12.5 to E13.0, although the yolk sac lacked well-developed vessels. Electron microscopic examination showed endothelial cells to be partially detached from the basement structure at E12.5 in vitelline vessels and hepatic capillaries, which allowed efflux of protoerythrocytes through the disrupted barrier. The basement membrane was not clearly recognizable in the aorta and cervical artery, and the endothelial cells stood out from the wall of the lumen, only partially adhering to the basement structure. AM +/− mice survived to adulthood but exhibited elevated blood pressures with diminished nitric oxide production. Conclusions AM is indispensable for the vascular morphogenesis during embryonic development and for postnatal regulation of blood pressure by stimulating nitric oxide production.
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Cites
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Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Brain, S. D., & Grant, A. D. (2004) · Physiological Reviews · doi:10.1152/physrev.00037.2003 · Cited by 765
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
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Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues
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Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta
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Metadata
- Authors
- Shindo, T., Kurihara, Y., Nishimatsu, H., Moriyama, N., Kakoki, M., Wang, Y., Imai, Y., Ebihara, A., Kuwaki, T., Ju, K.-H., Minamino, N., Kangawa, K., Ishikawa, T., Fukuda, M., Akimoto, Y., Kawakami, H., Imai, T., Morita, H., Yazaki, Y., Nagai, R., Hirata, Y., & Kurihara, H.
- Venue
- Circulation
- Published
- 2001-10-16
- Volume
- 104
- Issue
- 16
- Pages
- 1964-1971
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2030866439
- Cited by
- 297
- References
- 29
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shindo, T., Kurihara, Y., Nishimatsu, H., Moriyama, N., Kakoki, M., Wang, Y., Imai, Y., Ebihara, A., Kuwaki, T., Ju, K.-H., Minamino, N., Kangawa, K., Ishikawa, T., Fukuda, M., Akimoto, Y., Kawakami, H., Imai, T., Morita, H., Yazaki, Y., . . . Kurihara, H. (2001). Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene. Circulation. https://doi.org/10.1161/hc4101.097111
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