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hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules
Open accessAbstract
A 19 kDa protein was identified in specific granules of human neutrophils. A full‐length cDNA clone was isolated from a human CML cDNA library, based on amino‐acid sequences of isolated tryptic fragments. This clone includes the recently identified cDNA for FALL‐39/CAP‐18. Aminoacid sequences of proteolytic fragments derived both from the conserved N‐terminal cathelin‐like region and the highly variable C‐terminal region characteristic of this family of bactericidal, LPS binding proteins, were in complete agreement with the sequence deduced from the cDNA. Thus, the 19 kDa protein is hCAP‐18, stored as a ‘pro‐peptide’ in specific granules.
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Citations
Cited by
Granules of the Human Neutrophilic Polymorphonuclear Leukocyte
Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,522
Self-citationAmphipathic, α-helical antimicrobial peptides
Tossi, A., Sandri, L., & Giangaspero, A. (2000) · Biopolymers · doi:10.1002/1097-0282(2000)55:1<4::aid-bip30>3.0.co;2-m · Cited by 1,247
Yang, D., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J. M., Wooters, J., Oppenheim, J. J., & Chertov, O. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1069 · Cited by 1,240
Neutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Self-citationAntibacterial peptides: basic facts and emerging concepts
Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,158
Metadata
- Authors
- Cowland, J. B., Johnsen, A. H., & Borregaard, N.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-07-10
- Volume
- 368
- Issue
- 1
- Pages
- 173-176
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1986224819
- Cited by
- 350
- References
- 0
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules. https://app.cochat.ai/papers/10.1016/0014-5793(95)00634-l
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- Cowland, J. B., Johnsen, A. H., & Borregaard, N. (1995). hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules. FEBS Letters. https://doi.org/10.1016/0014-5793(95)00634-l
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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