Cited by 1,162Neutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Peptides and ActivitiesInflammation biomarkers and pathways

Neutrophil granules and secretory vesicles in inflammation

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Faurschou, Mikkel, Borregaard, Niels·2003·Microbes and Infection

Abstract

The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the destruction of phagocytosed microorganisms. Neutrophil granules contain a multitude of antimicrobial and potentially cytotoxic substances that are delivered to the phagosome or to the exterior of the cell following degranulation. This review summarises current knowledge of granule biology and highlights the effects of neutrophil degranulation in the acute inflammatory response.

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Crossref · 10.1016/j.micinf.2003.09.008

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  • PMNs carry three different types of granules: primary azurophilic, secondary specific, and tertiary gelatinase granules, which contain distinct anti-microbial effector molecules.

    “PMNs carry three different types of granules (Fig. 1): primary azurophilic, secondary specific, and tertiary gelatinase granules. These granules contain distinct anti-microbial effector molecules.”

    From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [114]

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Research works printed but not linked: 2

  1. S.S. Spicer, J.H. Hardin, Ultrastructure, cytochemistry, and function of neutrophil leukocyte granules, A review, Lab. Invest. 20 (1969) 488-497.
  2. H. Sengelov, L. Kjeldsen, M.S. Diamond, T.A. Springer, N. Borre- gaard, Subcellular localization and dynamics of Mac-1 (alpha and beta 2) in human neutrophils, J. Clin. Invest. 92 (1993) 1467-1476.

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Authors
Faurschou, M., & Borregaard, N.
Affiliations
University of Copenhagen (DK)
Corresponding author
Borregaard, Niels
Venue
Microbes and Infection
Publisher
Elsevier BV
Published
2003-11
Volume
5
Issue
14
Pages
1317-1327
ISSN
1286-4579 (ISSN-L)
OpenAlex
W2045362817
Cited by
1,162
References
132
Citations by year
2026: 27 · 2025: 46 · 2024: 17 · 2023: 42 · 2022: 42 · 2021: 64 · 2020: 56 · 2019: 56 · 2018: 47 · 2017: 60 · 2016: 48 · 2015: 57 · 2014: 53 · 2013: 83 · 2012: 63
FWCI
3.17
Type
journal article
Language
en
Open access
Locations
  • Microbes and Infection (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • Lundbeckfonden
  • H. Lundbeck A/S
  • Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
neutrophils, neutrophil granules, secretory vesicles, exocytosis, degranulation, innate immunity, acute inflammation, antimicrobial peptides, phagosome, phagocytosis, neutrophil effector functions
MeSH terms
Cytoplasmic Granules, Exocytosis, Humans, Inflammation, Neutrophils, Cell Degranulation, Secretory Vesicles

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