Neutrophil granules and secretory vesicles in inflammation
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The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the destruction of phagocytosed microorganisms. Neutrophil granules contain a multitude of antimicrobial and potentially cytotoxic substances that are delivered to the phagosome or to the exterior of the cell following degranulation. This review summarises current knowledge of granule biology and highlights the effects of neutrophil degranulation in the acute inflammatory response.
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PMNs carry three different types of granules: primary azurophilic, secondary specific, and tertiary gelatinase granules, which contain distinct anti-microbial effector molecules.
“PMNs carry three different types of granules (Fig. 1): primary azurophilic, secondary specific, and tertiary gelatinase granules. These granules contain distinct anti-microbial effector molecules.”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [114]
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- Authors
- Faurschou, M., & Borregaard, N.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Borregaard, Niels
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 5
- Issue
- 14
- Pages
- 1317-1327
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W2045362817
- Cited by
- 1,162
- References
- 132
- Citations by year
- 2026: 27 · 2025: 46 · 2024: 17 · 2023: 42 · 2022: 42 · 2021: 64 · 2020: 56 · 2019: 56 · 2018: 47 · 2017: 60 · 2016: 48 · 2015: 57 · 2014: 53 · 2013: 83 · 2012: 63
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Lundbeckfonden
- H. Lundbeck A/S
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- neutrophils, neutrophil granules, secretory vesicles, exocytosis, degranulation, innate immunity, acute inflammation, antimicrobial peptides, phagosome, phagocytosis, neutrophil effector functions
- MeSH terms
- Cytoplasmic Granules, Exocytosis, Humans, Inflammation, Neutrophils, Cell Degranulation, Secretory Vesicles
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