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Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain
Abstract
A novel protein family, showing a conserved proregion and a variable C‐terminal antimicrobial domain, and named0 cathelicidin, has been identified in mammalian myeloid cells. The conserved proregion shows sequence similarity to members of the cystatin superfamily of cysteine proteinase inhibitors. Cathelicidins are stored in the cytoplasmic granules of neutrophil leukocytes and release the antimicrobial peptides upon leukocyte activation. Some of these peptides can assume an α‐helical conformation, others contain one or two disulfide bonds, still others are Pro‐ and Arg‐rich, or Trp‐rich. In addition to bacterial killing, some of these peptides exert additional functions related to host defense such as LPS‐neutralization and promotion of wound healing.
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Citations
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
LL-37, the only human member of the cathelicidin family of antimicrobial peptides
Dürr, U. H. N., Sudheendra, U. S., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.030 · Cited by 1,049
Cathelicidins, multifunctional peptides of the innate immunity
Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988
Self-citationSørensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., & Borregaard, N. (2001) · Blood · doi:10.1182/blood.v97.12.3951 · Cited by 894
Frohm, M., Agerberth, B., Ahangari, G., Ståhle-Bäckdahl, M., Lidén, S., Wigzell, H., & Gudmundsson, G. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15258 · Cited by 803
Metadata
- Authors
- Zanetti, M., Gennaro, R., & Romeo, D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-10-23
- Volume
- 374
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2051142131
- Cited by
- 713
- References
- 0
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zanetti, M., Gennaro, R., & Romeo, D. (1995). Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain. FEBS Letters. https://doi.org/10.1016/0014-5793(95)01050-o
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