Cited by 606Metabolism, Diabetes, and CancerBiochemical and Molecular ResearchProtein Kinase Regulation and GTPase Signaling

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5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C α and native bovine protein phosphatase‐2A c

S P Davies, Nicholas R. Helps, Philip Cohen, David Grahame Hardie·1995·FEBS Letters

DOI 10.1016/0014-5793(95)01368-7

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Abstract

Human protein phosphatase-2C alpha (PP2C alpha) was purified to homogeneity after expression in Escherichia coli. AMP inhibited the dephosphorylation of AMP-activated protein kinase (AMPK), but not phosphocasein, by PP2C alpha. The concentration dependence and the effects of other nucleotides (ATP and formycin A-5'-monophosphate) suggest that AMP acts by binding to the same site which causes direct allosteric activation of AMPK. A similar, although less pronounced, effect was observed with another protein phosphatase (PP2AC). We have now shown that AMPK activates the AMPK cascade by four mechanisms, which should make the system exquisitely sensitive to changes in AMP concentration.

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10.1111/j.1432-1033.1995.0558k.x · DOI
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Additional file 3 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 13 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 15 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 6 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 5 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 16 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 18 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 20 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 19 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 11 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 12 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Additional file 1 of Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
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Authors: Davies, S. P., Helps, N. R., Cohen, P., & Hardie, D. G.
Affiliations: University of Dundee (GB)
ORCID: Philip Cohen
David Grahame Hardie
Venue: FEBS Letters
Publisher: Wiley
Published: 1995-12-27
Volume: 377
Issue: 3
Pages: 421-425
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/0014-5793(95)01368-7
OpenAlex: W2030636484
Cited by: 595
References: 19
Citations by year: 2026: 7 · 2025: 6 · 2024: 18 · 2023: 11 · 2022: 16 · 2021: 25 · 2020: 23 · 2019: 17 · 2018: 21 · 2017: 28 · 2016: 25 · 2015: 30 · 2014: 36 · 2013: 32 · 2012: 35
FWCI: 3.22
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1532 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: AMPK, AMP, dephosphorylation, phosphorylation, allosteric activation, nucleotide binding, formycin A, energy homeostasis
MeSH terms: Protein Phosphatase 2C, Adenosine Monophosphate, Allosteric Regulation, Animals, Base Sequence, Cattle, Dose-Response Relationship, Drug, Enzyme Activation, Escherichia coli, Humans, Isoenzymes, Models, Biological, Molecular Sequence Data, Multienzyme Complexes, Nucleotides, Phosphoprotein Phosphatases, Phosphorylation, Protein Kinases, Recombinant Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Protein Phosphatase 2, AMP-Activated Protein Kinases

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5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C α and native bovine protein phosphatase‐2A c

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