Hardie, D. Grahame

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 4,602

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,799

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 2,287

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,638

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,589

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., et al. (2004) · The EMBO Journal

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,381

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 1,317

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,264

Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation

O'Neill, L. A. J., & Hardie, D. G. (2013) · Nature

Immune cells in cancerMetabolism, Diabetes, and Cancer

Cited by 1,133

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

Hardie, D. G. (2003) · Endocrinology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 994

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine

Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated Receptors

Cited by 893

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

Hardie, D. G., Schaffer, B. E., & Brunet, A. (2016) · Trends in Cell Biology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 859

AMP-Activated Protein Kinase – Development of the Energy Sensor Concept

Hardie, D. G., Hawley, S. A., & Scott, J. W. (2006) · The Journal of Physiology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 813

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

Winder, W. W., & Hardie, D. G. (1996) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 799

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 797

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 773

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G., & Hardie, D. G. (2004) · Journal of Clinical Investigation

Biochemical and Molecular ResearchMetabolism, Diabetes, and Cancer

Cited by 754

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

Hawley, S. A., Gadalla, A. E., Olsen, G. S., & Hardie, D. G. (2002) · Diabetes

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 696

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

CHEUNG, P. C. F., SALT, I. P., DAVIES, S. P., HARDIE, D. G., & CARLING, D. (2000) · Biochemical Journal

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 637

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

Carling, D., Zammit, V. A., & Hardie, D. G. (1987) · FEBS Letters

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 599

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C α and native bovine protein phosphatase‐2A c

Davies, S. P., Helps, N. R., Cohen, P., & Hardie, D. G. (1995) · FEBS Letters

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 595

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 555

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

Gowans, G. J., Hawley, S. A., Ross, F. A., & Hardie, D. G. (2013) · Cell Metabolism

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 531

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G. (2015) · Current Opinion in Cell Biology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 485