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SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases
Open accessAbstract
Stress‐activated protein kinases are MAP kinase homologues that are activated by cellular stresses, bacterial endotoxin and inflammatory cytokines. They are activated by a dual threonine/tyrosine phosphorylation within a TPY sequence in the case of stress‐activated protein kinase‐1 and its isoforms (also called JNKs) or a TGY sequence in the case of stress‐activated protein kinase‐2 and its isoforms (also called p38, p40, RK, CSBPs, XMpk2 and Mxi2). Here we report the cloning and sequencing of a new protein kinase from rat with a TGY sequence in the activation domain. This stress‐activated protein kinase‐3 is 60% identical to mouse stress‐activated protein kinase‐2 and 45% identical to HOG1 from Saccharomyces cerevisiae. Transcripts encoding stress‐activated protein kinase‐3 are widely expressed, with high levels in skeletal muscle.
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Cites
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555
Cited by
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,382
Keshet, Y., & Seger, R. (2010) · Methods in Molecular Biology · doi:10.1007/978-1-60761-795-2_1 · Cited by 642
Alsayed, Y., Uddin, S., Mahmud, N., Lekmine, F., Kalvakolanu, D. V., Minucci, S., Bokoch, G., & Platanias, L. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007431200 · Cited by 161
P38-γ–dependent gene silencing restricts entry into the myogenic differentiation program
Gillespie, M. A., Le Grand, F., Scimè, A., Kuang, S., von Maltzahn, J., Seale, V., Cuenda, A., Ranish, J. A., & Rudnicki, M. A. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907037 · Cited by 131
Metadata
- Authors
- Mertens, S., Craxton, M., & Goedert, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-04
- Volume
- 383
- Issue
- 3
- Pages
- 273-276
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2056676481
- Cited by
- 158
- References
- 1
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mertens, S., Craxton, M., & Goedert, M. (1996). SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases. FEBS Letters. https://doi.org/10.1016/0014-5793(96)00255-4
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