Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,354 · see citing works

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,974 · see citing works

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188 · see citing works

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647 · see citing works

The stress-activated protein kinase subfamily of c-Jun kinases

Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601 · see citing works

The mitogen-activated protein kinase signal transduction pathway

Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,112 · see citing works

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Rouse, J. W., Cohen, P., Trigon, S., Morange, M., Alonso‐Llamazares, A., Zamanillo, D., Hunt, T., & Nebreda, Á. R. (1994) · Cell · doi:10.1016/0092-8674(94)90277-1 · Cited by 1,674 · see citing works

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

Gupta, S., Campbell, D., Dérijard, B., & Davis, R. J. (1995) · Science · doi:10.1126/science.7824938 · Cited by 1,440 · see citing works

An Osmosensing Signal Transduction Pathway in Yeast

Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248 · see citing works

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

Andersson, S., Davis, D. L., Dahlbäck, H., Jörnvall, H., & Russell, D. W. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83172-6 · Cited by 1,229 · see citing works

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

Maeda, T., Wurgler‐Murphy, S. M., & Saito, H. (1994) · Nature · doi:10.1038/369242a0 · Cited by 1,084 · see citing works

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

Minden, A., Lin, A., McMahon, M., Lange, C. A., Dérijard, B., Davis, R. J., Johnson, G. L., & Karin, M. (1994) · Science · doi:10.1126/science.7992057 · Cited by 1,069 · see citing works

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

Sánchez, I., Hughes, R. T., Mayer, B. J., Yee, K. O., Woodgett, J. R., Avruch, J., Kyriakls, J. M., & Zon, L. I. (1994) · Nature · doi:10.1038/372794a0 · Cited by 970 · see citing works

MAPKs: new JNK expands the group

Davis, R. J. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90132-5 · Cited by 944 · see citing works

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

Crews, C. M., Alessandrini, A., & Erikson, R. L. (1992) · Science · doi:10.1126/science.1411546 · Cited by 930 · see citing works

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

Yan, M., Dai, T., Deak, J. C., Kyriakis, J. M., Zon, L. I., Woodgett, J. R., & Templeton, D. J. (1994) · Nature · doi:10.1038/372798a0 · Cited by 705 · see citing works

An Osmosensing Signal Transduction Pathway in Mammalian Cells

Galcheva-Gargova, Z., Dérijard, B., Wu, I., & Davis, R. J. (1994) · Science · doi:10.1126/science.8047888 · Cited by 569 · see citing works

Identification of the sites in MAP kinase kinase‐1 phosphorylated by p74raf‐1.

Alessi, D. R., Saito, Y., Campbell, D. G., Cohen, P., Sithanandam, G., Rapp, U. R., Ashworth, A., Marshall, C. J., & Cowley, S. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06424.x · Cited by 562 · see citing works

The pathway to signal achievement

Egan, S. E., & Weinberg, R. A. (1993) · Nature · doi:10.1038/365781a0 · Cited by 560 · see citing works

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

Zheng, C., & Guan, K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06361.x · Cited by 403 · see citing works

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

Zheng, C. F., & Guan, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82142-1 · Cited by 336 · see citing works

The mitogen-activated protein kinase activator

Ahn, N. G., Seger, R., & Krebs, E. G. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90131-u · Cited by 284 · see citing works

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

Wartmann, M., & Davis, R. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37431-8 · Cited by 261 · see citing works

ERKs, extracellular signal-regulated MAP-2 kinases

Cobb, M. H., Robbins, D. J., & Boulton, T. G. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90124-h · Cited by 143 · see citing works

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

Ron, D., & Dressler, H. (1992) · PubMed · Cited by 136 · see citing works

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

Matsuda, S., Gotoh, Y., & Nishida, E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53690-5 · Cited by 126 · see citing works

Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.

Boguslawski, G., & Polazzi, J. O. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5848 · Cited by 104 · see citing works

Mitogen-Activated Protein (MAP) Kinase Phosphorylation of MAP Kinase Kinase: Determination of Phosphorylation Sites by Mass Spectrometry and Site-Directed Mutagenesis1

Mansour, S. J., Resing, K. A., Candi, J. M., Hermann, A. S., Gloor, J. W., Herskind, K. R., Wartmann, M., Davis, R. J., & Ahn, N. G. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124524 · Cited by 98 · see citing works

Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis.

Yashar, B. M., Kelley, C. M., Yee, K. O., Errede, B., & Zon, L. I. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5738 · Cited by 65 · see citing works

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,037 · see citing works

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,396 · see citing works

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274 · see citing works

AP-1 function and regulation

Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904 · see citing works

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

Widmann, C., Gibson, S. B., Jarpe, M. B., & Johnson, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,707 · see citing works

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,432 · see citing works

Rho GTPases and signaling networksPreprint

Aelst, L. V., & D’Souza‐Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358 · see citing works

Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications

Ryter, S. W., Alam, J., & Choi, A. M. K. (2006) · Physiological Reviews · doi:10.1152/physrev.00011.2005 · Cited by 2,308 · see citing works

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y. (1997) · Science · doi:10.1126/science.275.5296.90 · Cited by 2,310 · see citing works

LPS induction of gene expression in human monocytes.

Guha, M., & Mackman, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00149-2 · Cited by 2,441 · see citing works

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244 · see citing works

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153 · see citing works

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., & Lee, J. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00357-f · Cited by 2,086 · see citing works

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E. M., Zon, L. I., Kyriakis, J. M., et al. (1996) · Nature · doi:10.1038/380075a0 · Cited by 1,767 · see citing works

Signal Transduction through MAP Kinase Cascades

Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,746 · see citing works

How MAP Kinases Are Regulated

Cobb, M. H., & Goldsmith, E. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14843 · Cited by 1,718 · see citing works

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Gutkind, J. S. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,629 · see citing works

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543 · see citing works

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481 · see citing works

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

Kyriakis, J. M., & Avruch, J. (2012) · Physiological Reviews · doi:10.1152/physrev.00028.2011 · Cited by 1,476 · see citing works

Mitogen-activated protein kinases in apoptosis regulation

Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432 · see citing works

p38 MAP-Kinases pathway regulation, function and role in human diseases

Cuenda, A., & Rousseau, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.010 · Cited by 1,397 · see citing works

Selective interaction of JNK protein kinase isoforms with transcription factors.

Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341 · see citing works

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

Raingeaud, J., Whitmarsh, A. J., Barrett, T., Dérijard, B., & Davis, R. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1247 · Cited by 1,280 · see citing works

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,230 · see citing works

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170 · see citing works

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24313 · Cited by 1,083 · see citing works

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

Rosette, C., & Karin, M. (1996) · Science · doi:10.1126/science.274.5290.1194 · Cited by 1,034 · see citing works

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M

Yamamoto, K., Ichijo, H., & Korsmeyer, S. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8469 · Cited by 1,003 · see citing works

Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

Waskiewicz, A. J., Flynn, A., Proud, C. G., & Cooper, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1909 · Cited by 951 · see citing works

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

Whitmarsh, A. J., Shore, P., Sharrocks, A. D., & Davis, R. J. (1995) · Science · doi:10.1126/science.7618106 · Cited by 932 · see citing works

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

Kuan, C.-Y., Yang, D. D., Roy, D. R. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80727-8 · Cited by 889 · see citing works

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

Wang, Y., Huang, S., Sah, V. P., Ross, J., Brown, J. H., Han, J., & Chien, K. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2161 · Cited by 842 · see citing works

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

Lin, A., Minden, A., Martinetto, H., Claret, F.-X., Lange, C. A., Mercurio, F., Johnson, G. L., & Karin, M. (1995) · Science · doi:10.1126/science.7716521 · Cited by 763 · see citing works

Mitogen-activated protein kinase cascades and regulation of gene expression

Su, B., & Karin, M. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80131-2 · Cited by 747 · see citing works

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

Karin, M., & Hunter, T. R. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00151-5 · Cited by 752 · see citing works

Tumor necrosis factor in the heart

Meldrum, D. R. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r577 · Cited by 747 · see citing works

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J. A., Lin, S., & Han, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17920 · Cited by 746 · see citing works

Role of JNK activation in apoptosis: A double-edged sword

Liu, J., & Lin, A. (2005) · Cell Research · doi:10.1038/sj.cr.7290262 · Cited by 736 · see citing works

The Ethylene Signal Transduction Pathway in Plants

Ecker, J. R. (1995) · Science · doi:10.1126/science.7732375 · Cited by 735 · see citing works

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

Zhang, S., Han, J., Sells, M. A., Chernoff, J., Knaus, U. G., Ulevitch, R. J., & Bokoch, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23934 · Cited by 726 · see citing works

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense

Dunne, A., & O'Neill, L. A. J. (2003) · Science s STKE · doi:10.1126/stke.2003.171.re3 · Cited by 712 · see citing works

Protein kinase cascades activated by stress and inflammatory cytokines

Kyriakis, J. M., & Avruch, J. (1996) · BioEssays · doi:10.1002/bies.950180708 · Cited by 709 · see citing works

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

Lee, F. S., Hagler, J., Chen, Z. J., & Maniatis, T. (1997) · Cell · doi:10.1016/s0092-8674(00)81842-5 · Cited by 710 · see citing works

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

Guay, J., Lambert, H., Gingras-Breton, G., Lavoie, J. N., Huot, J., & Landry, J. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.3.357 · Cited by 705 · see citing works

TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway

Hocevar, B. A., Brown, T. L., & Howe, P. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1345 · Cited by 671 · see citing works

MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

Fukunaga, R., & Hunter, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1921 · Cited by 666 · see citing works

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652 · see citing works

CpG‐DNA‐specific activation of antigen‐presenting cells requires stress kinase activity and is preceded by non‐specific endocytosis and endosomal maturation

Häcker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R. M., Sparwasser, T. D., Heeg, K. M., Lipford, G. B., & Wagner, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6230 · Cited by 654 · see citing works

The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor.

Beyaert, R., Cuenda, A., Berghe, W. V., Plaisance, S., Lee, J. C., Haegeman, G., Cohen, P., & Fiers, W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00542.x · Cited by 650 · see citing works

Components of a New Human Protein Kinase Signal Transduction Pathway

Zhou, G., Bao, Z., & Dixon, J. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12665 · Cited by 642 · see citing works

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

Maeda, T., Takekawa, M., & Saito, H. (1995) · Science · doi:10.1126/science.7624781 · Cited by 640 · see citing works

FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.

Tan, Y., Rouse, J. W., Zhang, A., Cariati, S., Cohen, P., & Comb, M. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00840.x · Cited by 634 · see citing works

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

Bagrodia, S., Dérijard, B., Davis, R. J., & Cerione, R. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.27995 · Cited by 635 · see citing works

The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways

Ganju, R. K., Brubaker, S. A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., & Groopman, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23169 · Cited by 614 · see citing works

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

Chaudhari, N., Talwar, P., Parimisetty, A., Lefebvre d’Hellencourt, C., & Ravanan, P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00213 · Cited by 600 · see citing works

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3057-3067.2004 · Cited by 605 · see citing works

MAPK pathways in radiation responses

Dent, P., Yacoub, A., Fisher, P. B., Hagan, M. P., & Grant, S. (2003) · Oncogene · doi:10.1038/sj.onc.1206701 · Cited by 603 · see citing works

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

Ulloa, L., Ochani, M., Yang, H., Tanovic, M., Halperin, D. M., Yang, R., Czura, C. J., Fink, M. P., & Tracey, K. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192222999 · Cited by 585 · see citing works

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

Uchida, K., Shiraishi, M., Naito, Y., Torii, Y., Nakamura, Y., & Osawa, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2234 · Cited by 569 · see citing works

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

Waskiewicz, A. J., & Cooper, J. A. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80063-8 · Cited by 575 · see citing works

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

Huot, J., Houle, F., Marceau, F., & Landry, J. (1997) · Circulation Research · doi:10.1161/01.res.80.3.383 · Cited by 567 · see citing works

Regulation of intercellular adhesion molecule-1 (CD54) gene expression

Roebuck, K. A., & Finnegan, A. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.6.876 · Cited by 558 · see citing works

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

Xu, B.-E., English, J. M., Wilsbacher, J. L., Stippec, S., Goldsmith, E. J., & Cobb, M. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16795 · Cited by 540 · see citing works

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

Enslen, H., Raingeaud, J., & Davis, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1741 · Cited by 534 · see citing works

MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α

Ge, B., Gram, H., Padova, F. D., Huang, B. C. B., New, L., Ulevitch, R. J., Luo, Y., & Han, J. (2002) · Science · doi:10.1126/science.1067289 · Cited by 534 · see citing works

Induction of c‐fos expression through JNK‐mediated TCF/Elk‐1 phosphorylation.

Cavigelli, M., Dolfi, F., Claret, F. X., & Karin, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00284.x · Cited by 530 · see citing works

The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions

Keshet, Y., & Seger, R. (2010) · Methods in Molecular Biology · doi:10.1007/978-1-60761-795-2_1 · Cited by 642 · see citing works

From receptors to stress-activated MAP kinases

Ichijo, H. (1999) · Oncogene · doi:10.1038/sj.onc.1203129 · Cited by 519 · see citing works

Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585 · see citing works

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

Han, J., Lee, J., Jiang, Y., Li, Z., Feng, L., & Ulevitch, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2886 · Cited by 512 · see citing works

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

Mazure, N. M., Chen, E. Y., Laderoute, K. R., & Giaccia, A. J. (1997) · Blood · doi:10.1182/blood.v90.9.3322 · Cited by 498 · see citing works

Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells

Isoda, K., Young, J. L., Zirlik, A., MacFarlane, L. A., Tsuboi, N., Gerdes, N., Schönbeck, U., & Libby, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000201938.78044.75 · Cited by 499 · see citing works

Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance

Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497 · see citing works

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

Xing, J. W., Kornhauser, J. M., Xia, Z., Thiele, E. A., & Greenberg, M. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.1946 · Cited by 492 · see citing works

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

Denhardt, D. T. (1996) · Biochemical Journal · doi:10.1042/bj3180729 · Cited by 497 · see citing works

Ribotoxic Stress Response: Activation of the Stress-Activated Protein Kinase JNK1 by Inhibitors of the Peptidyl Transferase Reaction and by Sequence-Specific RNA Damage to the α-Sarcin/Ricin Loop in the 28S rRNA

Iordanov, M. S., Pribnow, D. G., Magun, J. L., Dinh, T.-H., Pearson, J. A., Chen, S. L.-Y., & Magun, B. E. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3373 · Cited by 497 · see citing works

Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK

Swantek, J. L., Cobb, M. H., & Geppert, T. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6274 · Cited by 491 · see citing works

JNK and p38 stresskinases — degenerative effectors of signal-transduction-cascades in the nervous system

Mielke, K., & Herdegen, T. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00042-8 · Cited by 489 · see citing works

Mechanism of p38 MAP kinase activation in vivoPreprint

Brancho, D., Tanaka, N., Jaeschke, A., Ventura, J., Kelkar, N., Tanaka, Y., Kyuuma, M., Takeshita, T., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1107303 · Cited by 490 · see citing works

Regulation and function of the JNK subgroup of MAP kinases

Minden, A., & Karin, M. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00018-8 · Cited by 486 · see citing works

p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps

Wu, Z.-G., Woodring, P. J., Bhakta, K. S., Tamura, K., Wen, F., Feramisco, J., Karin, M., Wang, J. Y. J., & Puri, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.3951-3964.2000 · Cited by 524 · see citing works

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.

Hambleton, J., Weinstein, S. L., Lem, L., & DeFranco, A. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2774 · Cited by 471 · see citing works

Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification

Rietschel, E., Brade, H., Holst, O., Brade, L., Müller‐Loennies, S., Mamat, U., Zähringer, U., Beckmann, F., Seydel, U., Brandenburg, K., et al. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80186-0_3 · Cited by 469 · see citing works

HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress.

Huot, J., Houle, F., Spitz, D. R., & Landry, J. (1996) · PubMed · Cited by 469 · see citing works

The vagus nerve and the nicotinic anti-inflammatory pathway

Ulloa, L. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1797 · Cited by 467 · see citing works

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

Kummer, J. L., Rao, P., & Heidenreich, K. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20490 · Cited by 468 · see citing works

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainPreprint

Baud, V., Liu, Z.-G., Bennett, B. L., Suzuki, N., Xia, Y., & Karin, M. (1999) · Genes & Development · doi:10.1101/gad.13.10.1297 · Cited by 464 · see citing works

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways1

Dent, P., Yacoub, A., Contessa, J. N., Carón, R. W., Amorino, G. P., Valerie, K. C., Hagan, M. P., Grant, S., & Schmidt‐Ullrich, R. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0283:sariao]2.0.co;2 · Cited by 465 · see citing works

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH 2 -Terminal Kinase

Lei, K., Nimnual, A. S., Zong, W., Kennedy, N. J., Flavell, R. A., Thompson, C. B., Bar‐Sagi, D., & Davis, R. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4929-4942.2002 · Cited by 463 · see citing works

p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation

Zetser, A., Gredinger, E., & Bengal, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5193 · Cited by 461 · see citing works

The ERK Cascade: A Prototype of MAPK Signaling

Rubinfeld, H., & Seger, R. (2005) · Molecular Biotechnology · doi:10.1385/mb:31:2:151 · Cited by 460 · see citing works

Inhibition of p38 MAP kinase as a therapeutic strategy

Lee, J. C., Kumar, S., Griswold, D. E., Underwood, D. C., Votta, B. J., & Adams, J. L. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)00206-x · Cited by 455 · see citing works

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

Whitmarsh, A. J., Yang, S., Su, M. S. S., Sharrocks, A. D., & Davis, R. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2360 · Cited by 454 · see citing works

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

Moriguchi, T., Kuroyanagi, N., Yamaguchi, T., Gotoh, Y., Irie, K., Takahisa, K. A. N. O., Shirakabe, K., Muro, Y., Shibuyà, H., Matsumoto, K., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13675 · Cited by 449 · see citing works

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

Zanke, B. W., Boudreau, K., Rubie, E. A., Winnett, E., Tibbles, L. A., Zon, L. I., Kyriakis, J. M., Liu, F., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00547-x · Cited by 444 · see citing works

The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression

Carter, A. B., Knudtson, K. L., Monick, M. M., & Hunninghake, G. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30858 · Cited by 443 · see citing works

Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

Deacon, K., & Blank, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14489 · Cited by 111 · see citing works

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

Han, J., Lee, J., Jiang, Y., Li, Z., Feng, L., & Ulevitch, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2886 · Cited by 512 · see citing works

Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

Gerwins, P., Jonathan, L., & Johnson, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8288 · Cited by 242 · see citing works

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

Blank, J. L., Gerwins, P., Elliott, E. M., Sather, S., & Johnson, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5361 · Cited by 230 · see citing works

MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases

Deacon, K., & Blank, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16604 · Cited by 93 · see citing works