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Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture
Abstract
We studied whether the TGF‐β‐induced apoptosis in fetal hepatocyte primary cultures may be modulated by the presence of mitogenic stimuli, such as EGF or HGF. EGF prevented cell death, showing a dose dependence that was identical to that observed for its effect on DNA synthesis stimulation. HGF, in contrast, had no effect, even at high concentrations. EGF blocked apoptosis, since in the presence of this factor cells did not show DNA fragmentation. Moreover, EGF, but not HGF, blocked c‐fos induction associated with the apoptotic process induced by TGF‐β in these cells.
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TPA and EGF are potent promotors for carcinogenesis.
“12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) are well known potent promotors for carcinogenesis [1,2].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [2]
EGF is a potent growth promoting factor for hepatocytes and inhibits TGF-β1-induced apoptosis.
“Epidermal growth factor (EGF) is a potent growth promoting factor for hepatocytes and inhibits the TGF-β1-induced apoptosis [2].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [2]
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Metadata
- Authors
- Fabregat, I., Sanchez, A., Alvarez, A. M., Nakamura, T., & Benito, M.
- Affiliations
- Universidad Complutense de Madrid (ES)
- The University of Osaka (JP)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-04-08
- Volume
- 384
- Issue
- 1
- Pages
- 14-18
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2064759337
- Cited by
- 70
- References
- 26
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1 · 2015: 2 · 2013: 1
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- epidermal growth factor, hepatocyte growth factor, TGF-beta, apoptosis, fetal hepatocytes, c-fos induction, DNA fragmentation, mitogen stimulation, cell death inhibition
- MeSH terms
- Animals, Cell Nucleus, Cell Survival, Cells, Cultured, DNA, DNA Damage, Dose-Response Relationship, Drug, Epidermal Growth Factor, Fetus, Flow Cytometry, Liver, Transforming Growth Factor beta, Proto-Oncogene Proteins c-fos, Genes, fos, Rats, Wistar, Apoptosis, Hepatocyte Growth Factor, Rats
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