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Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)
Abstract
Plasma‐stable liposomes (100 nm) were prepared from dioleoylphosphatidylethanolamine (DOPE) and 3–6 mol% of a new disulfide‐linked poly(ethylene glycol)‐phospholipid conjugate (mPEG‐DTP‐DSPE). In contrast to similar preparations containing non‐cleavable PEG‐phospholipid conjugate, thiolytic cleavage of the grafted polymer chains facilitated rapid and complete release of the liposome contents. Furthermore, the detachment of PEG from DOPE liposomes resulted in liposomal fusion. Finally, while formulation of pH‐sensitive DOPE/cholesterol hemisuccinate liposomes with mPEG‐DTP‐DSPE abolished the pH sensitivity, cleavage of the PEG chains completely restored this property. These are the first examples of new useful properties of liposomes grafted with cleavable polymer.
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Cites
Holland, J. W., Hui, C., Cullis, P. R., & Madden, T. D. (1996) · Biochemistry · doi:10.1021/bi952000v · Cited by 223
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Metadata
- Authors
- Kirpotin, D., Hong, K., Mullah, N., Papahadjopoulos, D., & Zalipsky, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-06-17
- Volume
- 388
- Issue
- 2-3
- Pages
- 115-118
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2078211781
- Cited by
- 206
- References
- 1
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kirpotin, D., Hong, K., Mullah, N., Papahadjopoulos, D., & Zalipsky, S. (1996). Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol). FEBS Letters. https://doi.org/10.1016/0014-5793(96)00521-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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