Strategies in the design of nanoparticles for therapeutic applications

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works

Recent advances with liposomes as pharmaceutical carriers

Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works

Diffusion of univalent ions across the lamellae of swollen phospholipids

Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664 · see citing works

Renal clearance of quantum dots

Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476 · see citing works

Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works

Regulated portals of entry into the cell

Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,816 · see citing works

Integrins in cancer: biological implications and therapeutic opportunities

Desgrosellier, J. S., & Cheresh, D. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2748 · Cited by 3,721 · see citing works

Factors affecting the clearance and biodistribution of polymeric nanoparticles

Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699 · see citing works

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

Pierschbacher, M. D., & Ruoslahti, E. I. (1984) · Nature · doi:10.1038/309030a0 · Cited by 3,670 · see citing works

Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637 · see citing works

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works

Impact of Nanotechnology on Drug Delivery

Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,364 · see citing works

Biodegradable Long-Circulating Polymeric Nanospheres

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,924 · see citing works

The effect of particle design on cellular internalization pathways

Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918 · see citing works

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

Rejman, J., Oberle, V., Zuhorn, I. S., & Hoekstra, D. (2004) · Biochemical Journal · doi:10.1042/bj20031253 · Cited by 2,872 · see citing works

Nanoparticles in Medicine: Therapeutic Applications and Developments

Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685 · see citing works

Shape effects of filaments versus spherical particles in flow and drug delivery

Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., & Discher, D. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.70 · Cited by 2,565 · see citing works

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D. B., Tolcher, A. W., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,508 · see citing works

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

Gradishar, W. J., Tjulandin, S., Davidson, N. G. P., Shaw, H., Desai, N. P., Bhar, P., Hawkins, M., & O’Shaughnessy, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.937 · Cited by 2,159 · see citing works

A review of stimuli-responsive nanocarriers for drug and gene delivery

Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,157 · see citing works

Role of target geometry in phagocytosis

Champion, J. A., & Mitragotri, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600997103 · Cited by 2,082 · see citing works

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030 · see citing works

Polymer conjugates as anticancer nanomedicines

Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956 · see citing works

Immunological properties of engineered nanomaterials

Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823 · see citing works

Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope

Bangham, A. D., & Horne, R. W. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80115-7 · Cited by 1,810 · see citing works

Active targeting schemes for nanoparticle systems in cancer therapeutics

Byrne, J. D., Betancourt, T., & Brannon‐Peppas, L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.005 · Cited by 1,732 · see citing works

PEGylated nanoparticles for biological and pharmaceutical applications

Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00226-0 · Cited by 1,587 · see citing works

Nanocarriers’ entry into the cell: relevance to drug delivery

Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,549 · see citing works

Physical approaches to biomaterial design

Mitragotri, S., & Lahann, J. (2009) · Nature Materials · doi:10.1038/nmat2344 · Cited by 1,445 · see citing works

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities

Saito, G., Swanson, J. A., & Lee, K.-D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00179-5 · Cited by 1,407 · see citing works

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Brem, H., Piantadosi, S., Burger, P. C., Walker, M., Selker, R. G., Vick, N. A., Black, K. L., Sisti, M. B., Brem, S. S., Mohr, G., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90755-6 · Cited by 1,390 · see citing works

Optimizing Liposomes for Delivery of Chemotherapeutic Agents to Solid Tumors

Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., & Papahadjopoulos, D. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01426-1 · Cited by 1,265 · see citing works

Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers

Champion, J. A., Katare, Y. K., & Mitragotri, S. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.03.022 · Cited by 1,207 · see citing works

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

Low, P. S., Henne, W. A., & Doorneweerd, D. D. (2007) · Accounts of Chemical Research · doi:10.1021/ar7000815 · Cited by 1,174 · see citing works

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

Sugahara, K. N., Teesalu, T., Karmali, P. P., Kotamraju, V. R., Agemy, L., Girard, O. M., Hanahan, D., Mattrey, R. F., & Ruoslahti, E. I. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.013 · Cited by 1,140 · see citing works

Reduction-sensitive polymers and bioconjugates for biomedical applications

Meng, F., Hennink, W. E., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.026 · Cited by 1,132 · see citing works

Structure and properties of pharmacologically active polymers

Ringsdorf, H. (1975) · Journal of Polymer Science: Polymer Symposia · doi:10.1002/polc.5070510111 · Cited by 1,094 · see citing works

Amphiphilic block copolymers for drug delivery

Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078 · see citing works

Endocytic mechanisms for targeted drug delivery☆

Bareford, L. M., & Swaan, P. W. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.008 · Cited by 1,035 · see citing works

Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody

Miller, R. A., Maloney, D. G., Warnke, R. A., & Levy, R. (1982) · New England Journal of Medicine · doi:10.1056/nejm198203043060906 · Cited by 985 · see citing works

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

Davis, M. E. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900015y · Cited by 979 · see citing works

Size and shape effects in the biodistribution of intravascularly injected particles

Decuzzi, P., Godin, B., Tanaka, T., Lee, S., Chiappini, C., Liu, X., & Mauro Ferrari, B. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.014 · Cited by 968 · see citing works

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer

Kukowska‐Latallo, J. F., Candido, K. A., Cao, Z., Nigavekar, S. S., Majoros, I., Thomas, T. P., Balogh, L. P., Khan, M. K., & Baker, J. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3921 · Cited by 912 · see citing works

Transport of molecules across tumor vasculature

Jain, R. K. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00047468 · Cited by 869 · see citing works

Direct Fabrication and Harvesting of Monodisperse, Shape-Specific Nanobiomaterials

Rolland, J. P., Maynor, B. W., Euliss, L. E., Exner, A. E., Rothrock, G. D., & DeSimone, J. M. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051977c · Cited by 849 · see citing works

Targeting of drugs and nanoparticles to tumors

Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200910104 · Cited by 833 · see citing works

Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies

Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821 · see citing works

Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery

Sinha, R., Gloria, K., Nie, S., & Shin, D. M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0141 · Cited by 802 · see citing works

Surface Chemistry Influences Implant Biocompatibility

Tang, L., Thevenot, P., & Hu, W. (2008) · Current Topics in Medicinal Chemistry · doi:10.2174/156802608783790901 · Cited by 800 · see citing works

Nuclear Pore Complex Is Able to Transport Macromolecules with Diameters of ∼39 nm

Panté, N., & Kann, M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-06-0308 · Cited by 778 · see citing works

Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells

Vinogradov, S. V., Bronich, T. K., & Kabanov, A. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00245-9 · Cited by 776 · see citing works

Targeted pharmaceutical nanocarriers for cancer therapy and imaging

Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 758 · see citing works

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

Choi, C. H. J., Alabi, C. A., Webster, P. C., & Davis, M. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914140107 · Cited by 699 · see citing works

Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization

Fukumura, D., & Jain, R. K. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.05.003 · Cited by 699 · see citing works

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.

Vasey, P. A., Kaye, S. B., Morrison, R. A., Twelves, C. J., Wilson, P., Duncan, R., Thomson, A. H., Murray, L. S., Hilditch, T. E., Murray, T., et al. (1999) · PubMed · Cited by 689 · see citing works

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

Lee, C., Gillies, E. R., Fox, M. E., Guillaudeu, S. J., Fréchet, J. M. J., Dy, E. E., & Szoka, F. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607705103 · Cited by 648 · see citing works

Nanoparticles for drug delivery to the lungs

Sung, J. C., Pulliam, B., & Edwards, D. A. (2007) · Trends in biotechnology · doi:10.1016/j.tibtech.2007.09.005 · Cited by 644 · see citing works

The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

Daniels‐Wells, T. R., Delgado, T., Rodríguez, J. A., Helguera, G. F., & Penichet, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.010 · Cited by 630 · see citing works

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

Decuzzi, P., Pasqualini, R., Arap, W., & Mauro Ferrari, B. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9697-x · Cited by 618 · see citing works

Shape Induced Inhibition of Phagocytosis of Polymer Particles

Champion, J. A., & Mitragotri, S. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9626-z · Cited by 618 · see citing works

Tumour vascular targeting

Neri, D., & Bicknell, R. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1627 · Cited by 599 · see citing works

HPMA copolymers: Origins, early developments, present, and future☆

Kopec̆ek, J., & Kopečková, P. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.10.004 · Cited by 576 · see citing works

Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers

Muro, S., Garnacho, C., Champion, J. A., Leferovich, J. M., Gajewski, C., Schuchman, E. H., Mitragotri, S., & Muzykantov, V. R. (2008) · Molecular Therapy · doi:10.1038/mt.2008.127 · Cited by 564 · see citing works

Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer

Lee, K. S., Chung, H. C., Im, S. A., Park, Y. H., Kim, C. S., Kim, S.-B., Rha, S. Y., Lee, M. Y., & Ro, J. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9591-y · Cited by 541 · see citing works

Nanoparticles—a historical perspective

Kreuter, J. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.021 · Cited by 540 · see citing works

Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538 · see citing works

Biodegradable nanoparticles for cytosolic delivery of therapeutics

VASIR, J., & LABHASETWAR, V (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.003 · Cited by 526 · see citing works

The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells

Daniels‐Wells, T. R., Delgado, T., Helguera, G. F., & Penichet, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.006 · Cited by 519 · see citing works

Polymer-based siRNA delivery: Perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery

Gary, D. J., Puri, N., & Won, Y. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.021 · Cited by 514 · see citing works

The role of complement in inflammation and phagocytosis

Frank, M. M., & Fries, L. F. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90009-i · Cited by 504 · see citing works

Which polymers can make nanoparticulate drug carriers long-circulating?

Torchilin, V. P., & Trubetskoy, V. S. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00022-y · Cited by 480 · see citing works

Biomimetic amplification of nanoparticle homing to tumors

Simberg, D., Duza, T., Park, J. H., Essler, M., Pilch, J., Zhang, L., Derfus, A. M., Yang, M., Hoffman, R. M., Bhatia, S. N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610298104 · Cited by 473 · see citing works

Biodegradable Nanogels Prepared by Atom Transfer Radical Polymerization as Potential Drug Delivery Carriers: Synthesis, Biodegradation, in Vitro Release, and Bioconjugation

Oh, J. K., Siegwart, D. J., Lee, H., Sherwood, G. A., Peteanu, L. A., Hollinger, J. O., Kataoka, K., & Matyjaszewski, K. A. (2007) · Journal of the American Chemical Society · doi:10.1021/ja069150l · Cited by 467 · see citing works

Prostate-specific membrane antigen is produced in tumor-associated neovasculature.

Chang, S. S., O’Keefe, D. S., Bacich, D. J., Reuter, V. E., Heston, W. D. W., & Gaudin, P. B. (1999) · PubMed · Cited by 465 · see citing works

Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid–PEG conjugates

Gabizon, A. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.01.011 · Cited by 464 · see citing works

Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

Murphy, E. A., Majeti, B. K., Barnes, L. A., Makale, M., Weis, S. M., Lutu-Fuga, K. M., Wrasidlo, W., & Cheresh, D. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803728105 · Cited by 454 · see citing works

Solvent-Resistant Photocurable “Liquid Teflon” for Microfluidic Device Fabrication

Rolland, J. P., van Dam, R. M., Schorzman, D. A., Quake, S. R., & DeSimone, J. M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031657y · Cited by 440 · see citing works

Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin

Seymour, L. W., Ferry, D. R., Anderson, D., Hesslewood, S., Julyan, P. J., Poyner, R., Doran, J., Young, A., Burtles, S. S., & Kerr, D. J. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.6.1668 · Cited by 435 · see citing works

Dendrimer-platinate: a novel approach to cancer chemotherapy.

Malik, N., Evagorou, E. G., & Duncan, R. (1999) · PubMed · Cited by 417 · see citing works

Drug entrapment in liposomes

Gregoriadis, G. C. (1973) · FEBS Letters · doi:10.1016/0014-5793(73)80394-1 · Cited by 414 · see citing works

Cell surface tumor endothelial markers are conserved in mice and humans.

Carson-Walter, E. B., Watkins, D. N., Nanda, A., Vogelstein, B., Kinzler, K. W., & Croix, B. S. (2001) · PubMed · Cited by 410 · see citing works

Dendrimer-platinate

Malik, N., Evagorou, E. G., & Duncan, R. (1999) · Anti-Cancer Drugs · doi:10.1097/00001813-199909000-00010 · Cited by 402 · see citing works

Imparting size, shape, and composition control of materials for nanomedicine

Euliss, L. E., DuPont, J. A., Gratton, S. E. A., et al. (2006) · Chemical Society Reviews · doi:10.1039/b600913c · Cited by 383 · see citing works

Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer

Danson, S., Ferry, D., Alakhov, V, Margison, J., Kerr, D., Jowle, D., Brampton, M., Halbert, G., & Ranson, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601856 · Cited by 382 · see citing works

The use of silicone rubber as a carrier for prolonged drug therapy

Folkman, J., & Long, D. M. (1964) · Journal of Surgical Research · doi:10.1016/s0022-4804(64)80040-8 · Cited by 368 · see citing works

Effects of the Chemical Structure and the Surface Properties of Polymeric Biomaterials on Their Biocompatibility

Wang, Y.-X., Robertson, J. L., Spillman, W. B., & Claus, R. O. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000036909.41843.18 · Cited by 357 · see citing works

The folate receptor: What does it promise in tissue-targeted therapeutics?

Salazar, M. D., & Ratnam, M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9048-0 · Cited by 350 · see citing works

PEGylated PLGA nanoparticles for the improved delivery of doxorubicin

Park, J. Y., Fong, P., Lu, J., Russell, K. S., Booth, C. J., Saltzman, W. M., & Fahmy, T. M. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.02.002 · Cited by 339 · see citing works

Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel

Danhier, F., Vroman, B., Lecouturier, N., Crokart, N., Pourcelle, V., Freichels, H., Jérôme, C., Marchand‐Brynaert, J., Féron, O., & Véronique Préat, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.08.011 · Cited by 335 · see citing works

Shrinkage of a Rapidly Growing Tumor by Drug-Loaded Polymersomes: pH-Triggered Release through Copolymer Degradation

Ahmed, F., Pakunlu, R. I., Srinivas, G., Brannan, A. K., Bates, F. S., Klein, M. L., Minko, T., & Discher, D. E. (2006) · Molecular Pharmaceutics · doi:10.1021/mp050103u · Cited by 330 · see citing works

Targeting Mitochondria with Organelle‐Specific Compounds: Strategies and Applications

Yousif, L. F., Stewart, K. M., & Kelley, S. O. (2009) · ChemBioChem · doi:10.1002/cbic.200900185 · Cited by 330 · see citing works

Biopharmaceutical Parameters to Consider in Order to Alter The Fate of Nanocarriers After Oral Delivery

Roger, E., Lagarce, F., Garcion, E., & Benoît, J. (2010) · Nanomedicine · doi:10.2217/nnm.09.110 · Cited by 324 · see citing works

Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns

Göppert, T. M., & Müller, R. H. (2005) · Journal of drug targeting · doi:10.1080/10611860500071292 · Cited by 299 · see citing works

Integrins and Angiogenesis

Stupack, D. G., & Cheresh, D. A. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)64009-9 · Cited by 297 · see citing works

Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin

Seymour, L. W., Ferry, D. R., Anderson, D., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.6.1668 · Cited by 287 · see citing works

From Combinatorial Chemistry to Cancer-Targeting Peptides

Aina, O. H., Liu, R., Sutcliffe-Goulden, J., Mařı́k, J., Pan, C.-X., & Lam, K. S. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700073y · Cited by 285 · see citing works

Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery

Torchilin, V. P. (2008) · Peptide Science · doi:10.1002/bip.20989 · Cited by 283 · see citing works

Nanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINT™ nanoparticles

Gratton, S. E. A., Pohlhaus, P. D., Lee, J., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.027 · Cited by 266 · see citing works

Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows

Lee, S., Mauro Ferrari, B., & Decuzzi, P. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/49/495101 · Cited by 259 · see citing works

Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases

Yamada, Y., & Harashima, H. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.04.016 · Cited by 258 · see citing works

Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape

Ilium, L., Davis, S. S., Wilson, C. G., et al. (1982) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(82)90113-2 · Cited by 254 · see citing works

Spatiotemporal controlled delivery of nanoparticles to injured vasculature

Chan, J. M., Zhang, L., Tong, R., Ghosh, D., Gao, W., Liao, G., Yuet, K. P., Gray, D. S., Rhee, J., Cheng, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914585107 · Cited by 253 · see citing works

Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects

Wong, J., Brugger, A. M., Khare, A. R., Chaubal, M. V., Papadopoulos, P., Rabinow, B. E., Kipp, J., & Ning, J. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.008 · Cited by 251 · see citing works

Synthesis and in Vitro Testing of J591 Antibody−Dendrimer Conjugates for Targeted Prostate Cancer Therapy

Patri, A. K., Myc, A., Beals, J. L., et al. (2004) · Bioconjugate Chemistry · doi:10.1021/bc0499127 · Cited by 249 · see citing works

Targeted delivery to the nucleus☆

Pouton, C. W., Wagstaff, K. M., ROTH, D., Moseley, G. W., & Jans, D. A. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.010 · Cited by 246 · see citing works

Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system – The concept of tissue specificity

Moghimi, S. M., & Patel, H. M. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00131-2 · Cited by 240 · see citing works

The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi’s sarcoma patients treated with pegylated liposomal doxorubicin

Berry, G. J., Billingham, M. E., Alderman, E. L., Richardson, P., Torti, F. M., Lum, B. L., Patek, A., & Martin, F. J. (1998) · Annals of Oncology · doi:10.1023/a:1008216430806 · Cited by 240 · see citing works

Designer Biomaterials for Nanomedicine

Doshi, N., & Mitragotri, S. (2009) · Advanced Functional Materials · doi:10.1002/adfm.200901538 · Cited by 238 · see citing works

Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo

Boddapati, S. V., D’Souza, G. G. M., Erdoğan, S., Torchilin, V. P., & Weissig, V. (2008) · Nano Letters · doi:10.1021/nl801908y · Cited by 234 · see citing works

Scalable, Shape-Specific, Top-Down Fabrication Methods for the Synthesis of Engineered Colloidal Particles

Merkel, T. J., Herlihy, K. P., Nunes, J. K., Orgel, R. M., Rolland, J. P., & DeSimone, J. M. (2009) · Langmuir · doi:10.1021/la903890h · Cited by 229 · see citing works

Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy

Misra, R., & Sahoo, S. K. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.11.010 · Cited by 218 · see citing works

Vascular Targeted Therapy With Anti–Prostate-Specific Membrane Antigen Monoclonal Antibody J591 in Advanced Solid Tumors

Milowsky, M. I., Nanus, D. M., Kostakoğlu, L., Sheehan, C. E., Vallabhajosula, S., Goldsmith, S. J., Ross, J. S., & Bander, N. H. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.8097 · Cited by 218 · see citing works

Polymers and nanoparticles: Intelligent tools for intracellular targeting?

Breunig, M., Bauer, S., & Göpferich, A. M. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.06.010 · Cited by 215 · see citing works

Quantum Dots Targeted to the Assigned Organelle in Living Cells

Hoshino, A., Fujioka, K., Oku, T., et al. (2004) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2004.tb03621.x · Cited by 210 · see citing works

Albumin microspheres for study of the reticuloendothelial system.

Scheffel, U., Rhodes, B. A., Natarajan, T. K., & Wagner, H. N. (1972) · PubMed · Cited by 207 · see citing works

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)

Kirpotin, D. B., Hong, K., Mullah, N. N., Papahadjopoulos, D., & Zalipsky, S. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00521-2 · Cited by 206 · see citing works

PEGylation of Nanocarrier Drug Delivery Systems: State of the Art

Howard, M. D., Jay, M., Dziubla, T. D., & Lü, X. (2008) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2008.021 · Cited by 203 · see citing works

Albumin Microspheres as Vehicles for Achieving Specificity in Drug Delivery

Kramer, P. A. (1974) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600631044 · Cited by 202 · see citing works

Methylation of the phosphate oxygen moiety of phospholipid‐methoxy(polyethylene glycol) conjugate prevents PEGylated liposome‐mediated complement activation and anaphylatoxin production

Moghimi, S. M., Hamad, I. M., Andresen, T. L., Jørgensen, K., & Szebeni, J. (2006) · The FASEB Journal · doi:10.1096/fj.06-6186fje · Cited by 201 · see citing works

Development of Biodegradable and Injectable Latices for Controlled Release of Potent Drugs

Gurny, R., Peppas, N. A., Harrington, D. D., & Banker, G. S. (1981) · Drug Development and Industrial Pharmacy · doi:10.3109/03639048109055684 · Cited by 198 · see citing works

Polymeric nanovehicles for anticancer drugs with triggering release mechanisms

Oh, K. T., Yin, H., Lee, E. S., & Bae, Y. H. (2007) · Journal of Materials Chemistry · doi:10.1039/b707142f · Cited by 196 · see citing works

Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles

Ogawara, K., Furumoto, K., Nagayama, S., Minato, K., Higaki, K., Kai, T., & Kimura, T. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.028 · Cited by 195 · see citing works

Long-Circulating Nanopartides Bearing Heparin or Dextran Covalently Bound to Poly(Methyl Methacrylate)

Passirani, C., BARRATT, G. M., Devissaguet, J., & Labarre, D. (1998) · Pharmaceutical Research · doi:10.1023/a:1011930127562 · Cited by 179 · see citing works

An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen

Moghimi, S. M., Hedeman, H., Muir, I. S., Illum, L., & Davis, S. S. (1993) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(93)90105-h · Cited by 176 · see citing works

The polyoxyethylene/polyoxypropylene block co‐polymer Poloxamer‐407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow

Porter, C. J. H., Moghimi, S. M., Illum, L., & Davis, S. S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80655-z · Cited by 173 · see citing works

The EPR Effect and Polymeric Drugs: A Paradigm Shift for Cancer Chemotherapy in the 21st Century

Maeda, H., Greish, K. F., & Fang, J. Q. (2005) · Advances in polymer science · doi:10.1007/12_026 · Cited by 173 · see citing works

Importins and Beyond: Non‐Conventional Nuclear Transport Mechanisms

Wagstaff, K. M., & Jans, D. A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00937.x · Cited by 169 · see citing works

HFT-T, a Targeting Nanoparticle, Enhances Specific Delivery of Paclitaxel to Folate Receptor-Positive Tumors

Wang, X., Li, J., Wang, Y., Cho, K.-J., Gloria, K., Gjyrezi, A., Koenig, L., Giannakakou, P., Shin, H. J. C., Tighiouart, M., et al. (2009) · ACS Nano · doi:10.1021/nn900649v · Cited by 165 · see citing works

Cardiac safety of liposomal anthracyclines

Ewer, M. S., Martin, F. J., Henderson, I. C., Shapiro, C. L., Benjamin, R. S., & Gabizón, A. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.08.006 · Cited by 162 · see citing works

Imaging angiogenesis and the microenvironment

Fukumura, D., & JAIN, R. K. (2008) · Apmis · doi:10.1111/j.1600-0463.2008.01148.x · Cited by 162 · see citing works

Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery

Zhang, Z., Cao, W., Jin, H., Lovell, J. F., Yang, M., Ding, L., Chen, J., Corbin, I. R., Luo, Q., & Zheng, G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200903112 · Cited by 159 · see citing works

An ein kolloidales Blutplasma-Ersatzmittel (Polyvinylpyrrolidon) gebundenes Peptamin (Glycyl-L-leucyl-mezcalin) als neuartige Depotform für biologisch aktive primäre Amine (Mezcalin)

Jatzkewitz, H. (1955) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1955-0106 · Cited by 154 · see citing works

Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles

Kattan, J. G., Droz, J., Couvreur, P., Marino, J. P., Boutan-Laroze, A., Rougier, P. R., Brault, P., Vranckx, H., Grognet, J., Morge, X., et al. (1992) · Investigational New Drugs · doi:10.1007/bf00877245 · Cited by 153 · see citing works

Shape-Specific, Monodisperse Nano-Molding of Protein Particles

Kelly, J. Y., & DeSimone, J. M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8014428 · Cited by 143 · see citing works

Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol®-PM) in patients with solid tumors

Lim, W., Tan, E. H., Toh, C., Hee, S. W., Leong, S. S., Ang, P., Wong, N. S., & Chowbay, B. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp315 · Cited by 142 · see citing works

The Pursuit of a Scalable Nanofabrication Platform for Use in Material and Life Science Applications

Gratton, S. E. A., Williams, S., Napier, M. E., Pohlhaus, P. D., Zhou, Z., Wiles, K. B., Maynor, B. W., Shen, C. K.-F., Olafsen, T., Samulski, E. T., et al. (2008) · Accounts of Chemical Research · doi:10.1021/ar8000348 · Cited by 142 · see citing works

Reductively Labile PRINT Particles for the Delivery of Doxorubicin to HeLa Cells

Petros, R. A., Ropp, P. A., & DeSimone, J. M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801436j · Cited by 137 · see citing works

DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers

Oupický, D., Koňák, Č., Ulbrich, K., et al. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00249-7 · Cited by 130 · see citing works

Biocompatibility of a Biodegradable, Controlled-Release Polymer in the Rabbit Brain

Brem, H., KADER, A., Epstein, J. I., Tamargo, R. J., Domb, A. J., Langer, R., & Leong, K. W. (1989) · Selective Cancer Therapeutics · doi:10.1089/sct.1989.5.55 · Cited by 130 · see citing works

Biologically Active Synthetic Polymers

Breslow, D. S. (1976) · Pure and Applied Chemistry · doi:10.1351/pac197646020103 · Cited by 128 · see citing works

Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover

Hamad, I. M., Hunter, A. C., Rutt, K. J., Liu, Z., Dai, H., & Moghimi, S. M. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.05.020 · Cited by 122 · see citing works

Designing polymer conjugates as lysosomotropic nanomedicines

Duncan, R. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350056 · Cited by 117 · see citing works

Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice

Oldenborg, P. (2002) · Blood · doi:10.1182/blood.v99.10.3500 · Cited by 108 · see citing works

Liposomes as targeted drug delivery systems in the treatment of breast cancer

Sharma, G., Anabousi, S., Ehrhardt, C., et al. (2006) · Journal of drug targeting · doi:10.1080/10611860600809112 · Cited by 103 · see citing works

Innovations in avoiding particle clearance from blood by Kupffer cells: cause for reflection.

Moghimi, S. M., & Davis, S. S. (1994) · PubMed · Cited by 103 · see citing works

Down-Regulation of Basophil Function by Human CD200 and Human Herpesvirus-8 CD200

Shiratori, I., Yamaguchi, M., Suzukawa, M., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4441 · Cited by 101 · see citing works

Nanoparticle Drug Delivery Platform

Napier, M. E., & DeSimone, J. M. (2007) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583720701454999 · Cited by 100 · see citing works

Cancer‐Cell‐Phenotype‐Dependent Differential Intracellular Trafficking of Unconjugated Quantum Dots

Barua, S., & Rege, K. (2008) · Small · doi:10.1002/smll.200800972 · Cited by 100 · see citing works

Microfabricated Particles for Engineered Drug Therapies: Elucidation into the Mechanisms of Cellular Internalization of PRINT Particles

Gratton, S. E. A., Napier, M. E., Ropp, P. A., Tian, S., & DeSimone, J. M. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9654-8 · Cited by 98 · see citing works

Structure, function and biological properties of integrin ?v?3on human melanoma cells

Cheresh, D. A. (1991) · Cancer and Metastasis Reviews · doi:10.1007/bf00046839 · Cited by 96 · see citing works

The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes

Souhami, R. L., Patel, H. M., & Ryman, B. E. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90366-4 · Cited by 93 · see citing works

Using nuclear targeting signals to enhance non‐viral gene transfer

Chan, C., & Jans, D. A. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01061.x · Cited by 89 · see citing works

Mitotic trafficking of silicon microparticles

Serda, R. E., Ferrati, S., Godin, B., et al. (2009) · Nanoscale · doi:10.1039/b9nr00138g · Cited by 88 · see citing works

Distribution and Elimination of Coated Polymethyl [2-14C]Methacrylate Nanoparticles After Intravenous Injection in Rats

Leu, D., Manthey, B., Kreuter, J., Speiser, P. P., & Delucax, P. P. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600731028 · Cited by 88 · see citing works

Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition

Furumoto, K., Yokoe, J.-I., Ogawara, K., AMANO, S., TAKAGUCHI, M., Higaki, K., Kai, T., & Kimura, T. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.026 · Cited by 79 · see citing works

Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats

YOKOE, J., SAKURAGI, S., YAMAMOTO, K., et al. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.008 · Cited by 78 · see citing works

THEORY TO PRACTICE:

Shepherd, P. L. (1983) · Gerontology & Geriatrics Education · doi:10.1300/j021v03n02_09 · Cited by 74 · see citing works

Lymphoma models for B cell activation and tolerance

Alés‐Martínez, J., Warner, G. L., & Scott, D. W. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90153-i · Cited by 72 · see citing works

Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines

Chan, C.-K., Senden, T. J., & Jans, D. A. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301275 · Cited by 71 · see citing works

HPMA copolymers: 30years of advances☆

Lammers, T., & Ulbrich, K. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.12.004 · Cited by 70 · see citing works

In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy

Schliemann, C., Roesli, C., Kamada, H., et al. (2009) · Blood · doi:10.1182/blood-2009-08-239004 · Cited by 64 · see citing works

Semitelechelic HPMA Copolymers Functionalized with Triphenylphosphonium as Drug Carriers for Membrane Transduction and Mitochondrial Localization

Callahan, J., & Kopec̆ek, J. (2006) · Biomacromolecules · doi:10.1021/bm060336m · Cited by 63 · see citing works

Delivery of drugs and macromolecules to mitochondria☆

Mukhopadhyay, A., & Weiner, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.004 · Cited by 55 · see citing works

Synthetic peptide ligands of the antigen binding receptor induce programmed cell death in a human B-cell lymphoma.

Renschler, M. F., Bhatt, R. R., Dower, W. J., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3623 · Cited by 52 · see citing works

Über den Einbau physiologisch wirksamer Substanzen in ein kollodiales Blutplasma-Ersatzmittel

Jatzkewitz, H. (1954) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1954.297.1.149 · Cited by 52 · see citing works

Lymphoma models for B cell activation and tolerance IV. Growth inhibition by anti‐Ig of CH31 and CH33 B lymphoma cells

Pennell, C. A., & Scott, D. W. (1986) · European Journal of Immunology · doi:10.1002/eji.1830161217 · Cited by 50 · see citing works

Identification of endothelial cell–surface proteins as targets for diagnosis and treatment of disease

Jacobson, B. S., Stolz, D. B., & Schnitzer, J. E. (1996) · Nature Medicine · doi:10.1038/nm0496-482 · Cited by 48 · see citing works

[Incorporation of physiologically-active substances into a colloidal blood plasma substitute. I. Incorporation of mescaline peptide into polyvinylpyrrolidone].

Jatzkewitz, H. (1954) · PubMed · Cited by 38 · see citing works

Liposome disposition in vivo: effects of pre-dosing with lipsomes.

Abra, R. M., Bosworth, M. E., & Hunt, C. A. (1980) · PubMed · Cited by 36 · see citing works

Drug delivery to peroxisomes: Employing unique trafficking mechanisms to target protein therapeutics☆

Terlecky, S. R., & Koepke, J. I. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.005 · Cited by 30 · see citing works

Development and Characterization of Drug Delivery Systems for Targeting Mammalian Cells and Tissues: A Review

Braun, K., Pipkorn, R., & Waldeck, W. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867054546672 · Cited by 27 · see citing works

Review: Advances in Intraperitoneal (Intracavitary) Administration of Synthetic Polymers for Immunotherapy and Chemotherapy

Regelson, W. (1986) · Journal of Bioactive and Compatible Polymers · doi:10.1177/088391158600100109 · Cited by 26 · see citing works

Technology evaluation: gemtuzumab ozogamicin, Celltech Group.

Niculescu‐Duvaz, I. (2000) · PubMed · Cited by 24 · see citing works

Strategies and Applications

(2011) · Advanced & emerging communications technologies/Advanced and emerging communications technologies series · doi:10.1201/b10981-2 · Cited by 20 · see citing works

Increase in the Vascular Residence Time of Propranolol-Loaded Nanoparticles Coated with Heparin

Socha, M., Lamprecht, A., Ghazouani, F. E., et al. (2008) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2008.081 · Cited by 14 · see citing works

The intracellular and nuclear‐targeted delivery of an antiandrogen drug by carrier peptides

Hodoniczky, J., Sims, C. G., Best, W. M., et al. (2008) · Biopolymers · doi:10.1002/bip.20986 · Cited by 11 · see citing works

Cellular uptake of nanoparticles: Journey inside the cell

Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859 · see citing works

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912 · see citing works

Delivery materials for siRNA therapeutics

Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800 · see citing works

Nanoparticles in the clinic: an update

Anselmo, A. C., & Mitragotri, S. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10143 · Cited by 1,766 · see citing works

Design of polymeric nanoparticles for biomedical delivery applications

Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717 · see citing works

Block copolymer micelles in nanomedicine applications

Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309 · see citing works

Nanoparticles in the clinic

Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321 · see citing works

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288 · see citing works

Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking

Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926 · see citing works

Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications

Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859 · see citing works

Enzyme-responsive nanoparticles for drug release and diagnostics

de la Rica, R., Aili, D., & Stevens, M. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.002 · Cited by 765 · see citing works

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704 · see citing works

Recent advances of cocktail chemotherapy by combination drug delivery systems

Hu, Q., Sun, W., Wang, C., & Gu, Z. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.022 · Cited by 625 · see citing works

Tailoring nanocarriers for intracellular protein delivery

Gu, Z., Biswas, A., Zhao, M., & Tang, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00227e · Cited by 543 · see citing works

Strategies to improve micelle stability for drug delivery

Lu, Y., Zhang, E., Yang, J., & Cao, Z. (2018) · Nano Research · doi:10.1007/s12274-018-2152-3 · Cited by 530 · see citing works

Self-assembled mRNA vaccines

Kim, J., Eygeris, Y., Gupta, M., & Sahay, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.014 · Cited by 514 · see citing works

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506 · see citing works

Multifunctional polymeric micelles for delivery of drugs and siRNA

Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works

Nanomedicine scale-up technologies: feasibilities and challenges

Paliwal, R., Babu, R. J., & Palakurthi, S. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0177-9 · Cited by 466 · see citing works

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

Qiao, L., Hu, S., Huang, K., Su, T., Li, Z., Vandergriff, A., Cores, J., Dinh, P.-U., Allen, T., Shen, D., et al. (2020) · Theranostics · doi:10.7150/thno.39434 · Cited by 404 · see citing works

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles

Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024374 · Cited by 403 · see citing works

Stimulus responsive nanogels for drug delivery

Zha, L., Banik, B., & Alexis, F. (2011) · Soft Matter · doi:10.1039/c0sm01307b · Cited by 391 · see citing works

Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy

Qiao, Y., Wan, J., Zhou, L., Ma, W., Yang, Y., Luo, W., Yu, Z., & Wang, H. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1527 · Cited by 332 · see citing works

State-of-the-art design and rapid-mixing production techniques of lipid nanoparticles for nucleic acid delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018) · Small Methods · doi:10.1002/smtd.201700375 · Cited by 332 · see citing works

Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers

Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.025 · Cited by 286 · see citing works

Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells

Wang, P., Rahman, M. A., Zhao, Z., Weiss, K., Zhang, C., Chen, Z., Hurwitz, S. J., Chen, Z. G., Shin, D. M., & Ke, Y. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b09024 · Cited by 269 · see citing works

Folate-decorated nanogels for targeted therapy of ovarian cancer

Nukolova, N. V., Oberoi, H. S., Cohen, S. M., Kabanov, A. V., & Bronich, T. K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.006 · Cited by 223 · see citing works

Physicochemical characterization of drug nanocarriers

Berbel Manaia, E., Paiva Abuçafy, M., Chiari-Andréo, B. G., Lallo Silva, B., Oshiro-Júnior, J. A., & Chiavacci, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s133832 · Cited by 207 · see citing works

Effect of Nanoparticle Composition, Size, Shape, and Stiffness on Penetration Across the Blood–Brain Barrier

Brown, T. D., Habibi, N., Wu, D., Lahann, J., & Mitragotri, S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00743 · Cited by 182 · see citing works

Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research

Huang, B.-W., & Gao, J.-Q. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.005 · Cited by 174 · see citing works

Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells

Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172 · see citing works

Recent Advances in Nanomicelles Delivery Systems.

Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works

Polylactide-<i>graft</i>-doxorubicin Nanoparticles with Precisely Controlled Drug Loading for pH-Triggered Drug Delivery

Yu, Y., Chen, C.-K., Law, W.-C., Weinheimer, E., Sengupta, S., Prasad, P. N., & Cheng, C. (2014) · Biomacromolecules · doi:10.1021/bm401471p · Cited by 134 · see citing works

Biodegradable Microalgae-Based Carriers for Targeted Delivery and Imaging-Guided Therapy toward Lung Metastasis of Breast Cancer

Zhong, D., Zhang, D., Xie, T., & Zhou, M. (2020) · Small · doi:10.1002/smll.202000819 · Cited by 132 · see citing works

Iron oxide-loaded nanotheranostics: major obstacles to in vivo studies and clinical translation

Schleich, N., Danhier, F., & Préat, V. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.024 · Cited by 124 · see citing works

Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Pei, Q., Yi, Q., & Tang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119671 · Cited by 121 · see citing works

Drug releasing nanoplatforms activated by alternating magnetic fields

Mertz, D., Sandre, O., & Bégin-Colin, S. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.02.025 · Cited by 119 · see citing works

Nanocosmetics and Nanomedicines

(2011) · doi:10.1007/978-3-642-19792-5 · Cited by 116 · see citing works

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance

Shiraishi, K., Kawano, K., Maitani, Y., Aoshi, T., Ishii, K. J., Sanada, Y., Mochizuki, S., Sakurai, K., & Yokoyama, M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.010 · Cited by 87 · see citing works

Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy

Muntimadugu, E., Kommineni, N., & Khan, W. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.010 · Cited by 82 · see citing works

Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells

Maiti, C., Parida, S., Kayal, S., Maiti, S., Mandal, M., & Dhara, D. (2018) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.7b18245 · Cited by 75 · see citing works

The effect of drug loading on micelle properties: solid-state NMR as a tool to gain structural insight

Callari, M., De Souza, P. L., Rawal, A., & Stenzel, M. H. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701471 · Cited by 68 · see citing works

LHRH-targeted nanogels as a delivery system for cisplatin to ovarian cancer

Nukolova, N. V., Oberoi, H. S., Zhao, Y., Chekhonin, V. P., Kabanov, A. V., & Bronich, T. K. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4003688 · Cited by 63 · see citing works

FRET Imaging Reveals Different Cellular Entry Routes of Self-Assembled and Disulfide Bonded Polymeric Micelles

Lee, S.-Y., Tyler, J. Y., Kim, S., Park, K., & Cheng, J.-X. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4003333 · Cited by 59 · see citing works

Theranostic implications of nanotechnology in multiple sclerosis: a future perspective.

Singh, A. V., Khare, M., Gade, W. N., & Zamboni, P. (2012) · Autoimmune Diseases · doi:10.1155/2012/160830 · Cited by 58 · see citing works

Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy

Zhang, Y., Li, P., Pan, H., Liu, L., Ji, M., Sheng, N., Wang, C., Cai, L., & Ma, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.023 · Cited by 56 · see citing works

Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies

Ghumman, S. A., Mahmood, A., Noreen, S., Rana, M., Hameed, H., Ijaz, B., Hasan, S., Aslam, A., & ur Rehman, M. F. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.103811 · Cited by 54 · see citing works

Human 3D Cultures as Models for Evaluating Magnetic Nanoparticle CNS Cytotoxicity after Short- and Repeated Long-Term Exposure

De Simone, U., Roccio, M., Gribaldo, L., Spinillo, A., Caloni, F., & Coccini, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071993 · Cited by 55 · see citing works

Controlled Release of Fe₃O₄ Nanoparticles in Encapsulated Microbubbles to Tumor Cells via Sonoporation and Associated Cellular Bioeffects

Yang, F., Zhang, M., He, W., Chen, P., Cai, X., Yang, L., Gu, N., & Wu, J. (2011) · Small · doi:10.1002/smll.201002185 · Cited by 51 · see citing works

Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation

Ghumman, S. A., Noreen, S., & tul Muntaha, S. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.03.181 · Cited by 42 · see citing works

Applications of biosensing atomic force microscopy in monitoring drug and nanoparticle delivery

Lamprecht, C., Hinterdorfer, P., & Ebner, A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.917078 · Cited by 46 · see citing works

Taro-corms mucilage-alginate microspheres for the sustained release of pregabalin: In vitro &amp; in vivo evaluation

Ghumman, S. A., Bashir, S., Noreen, S., Khan, A. M., & Malik, M. Z. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.08.100 · Cited by 39 · see citing works

Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia

Ebenezer, O., Comoglio, P., Wong, G. K.-S., & Tuszynski, J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044019 · Cited by 39 · see citing works

Novel siRNA delivery strategy: a new "strand" in CNS translational medicine?

Gherardini, L., Bardi, G., Gennaro, M., & Pizzorusso, T. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1310-8 · Cited by 28 · see citing works

Targeting of herbal bioactives through folate receptors: a novel concept to enhance intracellular drug delivery in cancer therapy

Gupta, A., Kaur, C. D., Saraf, S., & Saraf, S. (2017) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2016.1147581 · Cited by 27 · see citing works

Nanoparticle transport across model cellular membranes: when do solubility-diffusion models break down?

Smith, D. J., Leal, L. G., Mitragotri, S., & Shell, M. S. (2018) · Journal of Physics D: Applied Physics · doi:10.1088/1361-6463/aacac9 · Cited by 23 · see citing works

Nanocrystalline NiAl-TiC Composites Sintered by the Pulse Plasma Method

Rosinski, M., & Michalski, A. (2006) · Diffusion and defect data, solid state data. Part B, Solid state phenomena/Solid state phenomena · doi:10.4028/3-908451-22-1.233 · Cited by 1 · see citing works

Porous SiC Ceramics with Multiple Pore Structure Fabricated via Gelcasting and Solid State Sintering

Wang, F., Gao, Z.-F., Jiaqiang, X., et al. (2016) · Journal of Inorganic Materials · doi:10.15541/jim20150390

Effects of SiC contents on the microstructure and mechanical properties of Al4SiC4–SiC ceramic composites

Liu, H., Zhang, H., Zhu, M. L., et al. (2023) · Ceramics International · doi:10.1016/j.ceramint.2023.11.210 · Cited by 8 · see citing works

Effects of Graphene Transfer and Thermal Annealing on Anticorrosive Properties of Stainless Steel

Oh, J. H., Han, S.-M., Kim, T. Y., et al. (2017) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2017.15048