The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice
Open accessAbstract
We recently identified a novel human protein kinase, p160 ROCK, as a putative downstream target of the small GTPase Rho. Using the human ROCK cDNA as a probe, we isolated cDNA of two distinct, highly related sequences from mouse libraries. One encoded a mouse counterpart of human ROCK (ROCK‐I), and the other encoded a novel ROCK‐related kinase (ROCK‐II). Like ROCK/ROCK‐I, ROCK‐II also bound to GTP‐Rho selectively. ROCK‐I mRNA was ubiquitously expressed except in the brain and muscle, whereas ROCK‐II mRNA was expressed abundantly in the brain, muscle, heart, lung and placenta. These results suggest that at least two ROCK isoforms are present in a single species and play distinct roles in Rho‐mediated signalling pathways.
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Rho GTPases and signaling networks
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ROCKs: multifunctional kinases in cell behaviour
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Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells
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Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity
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Self-citation
Metadata
- Authors
- Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K., & Narumiya, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-08-26
- Volume
- 392
- Issue
- 2
- Pages
- 189-193
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2011379117
- Cited by
- 802
- References
- 17
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K., & Narumiya, S. (1996). ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice. FEBS Letters. https://doi.org/10.1016/0014-5793(96)00811-3
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