ROCKs: multifunctional kinases in cell behaviour
Abstract
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), a kinase acting downstream of RhoA.
“Treatment with Y-27632, an inhibitor of Rho-associated protein kinase (ROCK), a kinase acting downstream of RhoA 50-52 , had no strong effect on actin organization or cell shape in these conditions (Fig. 2a,c,e and Extended Data Fig. 2a-f), in agreement with serum starvation reducing the baseline RhoA activity.”
From Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling (2026) · cites this paper as [52]
Cites
Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00864-3 · Cited by 337 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions
Julian, L., & Olson, M. F. (2014) · Small GTPases · doi:10.4161/sgtp.29846 · Cited by 550 · see citing works
The clearance of dying cells: table for two
Green, D. R., Oguin, T. H., & Martinez, J. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.172 · Cited by 314 · see citing works
Zanin-Zhorov, A., Weiss, J. M., Nyuydzefe, M. S., Chen, W., Scher, J. U., Mo, R., Depoil, D., Rao, N., Liu, B., Wei, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414189111 · Cited by 262 · see citing works
Knipe, R. S., Tager, A. M., & Liao, J. K. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009381 · Cited by 233 · see citing works
Baer, A. S., Syed, Y. A., Kang, S. U., Mitteregger, D., Vig, R., ffrench-Constant, C., Franklin, R. J. M., Altmann, F., Lubec, G., & Kotter, M. R. (2009) · Brain · doi:10.1093/brain/awn334 · Cited by 211 · see citing works
Mechanical regulation of myofibroblast phenoconversion and collagen contraction
Hinz, B., McCulloch, C. A., & Coelho, N. M. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.027 · Cited by 182 · see citing works
Hirose, A., Tanikawa, T., Mori, H., Okada, Y., & Tanaka, Y. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.11.082 · Cited by 129 · see citing works
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas
Konstantinidou, G., Ramadori, G., Torti, F., Kangasniemi, K., Ramirez, R. E., Cai, Y., Behrens, C., Dellinger, M. T., Brekken, R. A., Wistuba, I. I., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0388 · Cited by 114 · see citing works
Socodato, R., Portugal, C. C., Canedo, T., Rodrigues, A., Almeida, T. O., Henriques, J. F., Vaz, S. H., Magalhães, J., Silva, C. M., Baptista, F. I., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107796 · Cited by 94 · see citing works
Zanin-Zhorov, A., & Blazar, B. R. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108823 · Cited by 74 · see citing works
Nalkurthi, C., Schroder, W. A., Melino, M., Irvine, K. M., Nyuydzefe, M., Chen, W., Liu, J., Teng, M. W. L., Hill, G. R., Bertolino, P., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2021.100386 · Cited by 75 · see citing works
Controlling Major Cellular Processes of Human Mesenchymal Stem Cells using Microwell Structures
Xu, X., Wang, W., Kratz, K., Fang, L., Li, Z., Kurtz, A., Ma, N., & Lendlein, A. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400415 · Cited by 49 · see citing works
Experimental Pharmacological Management of Psoriasis
Campione, E., Cosio, T., Di Prete, M., Lanna, C., Dattola, A., & Bianchi, L. (2021) · Journal of Experimental Pharmacology · doi:10.2147/jep.s265632 · Cited by 27 · see citing works
Meiring, J. C. M., Mahapatra, V., Liu, R., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Pelster José, A., Karhanova, A., Metallidou, I., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02079-4
- Authors
- Riento, K., & Ridley, A. J.
- Affiliations
- The Royal Free Hospital (GB)
- ORCID
- Ridley, Anne J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2003-06-01
- Volume
- 4
- Issue
- 6
- Pages
- 446-456
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2077603983
- Cited by
- 1,941
- References
- 1
- Citations by year
- 2026: 38 · 2025: 50 · 2024: 72 · 2023: 56 · 2022: 62 · 2021: 81 · 2020: 78 · 2019: 62 · 2018: 86 · 2017: 94 · 2016: 113 · 2015: 115 · 2014: 116 · 2013: 100 · 2012: 126
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- Rho kinase, rocks, serine/threonine kinase, cell motility, smooth muscle contraction, cell migration, neurite outgrowth, centrosome positioning, cell size control
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Insulin, Models, Biological, Muscle, Smooth, Phagocytosis, Phosphorylation, Phylogeny, Signal Transduction, Apoptosis, Protein Serine-Threonine Kinases, Protein Isoforms, Intracellular Signaling Peptides and Proteins, rho-Associated Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
