Gastrointestinal motility disturbances in patients with orthostatic hypotension
Open accessAbstract
Orthostatic hypotension syndromes may be associated with visceral denervation, resulting in disturbances of the gastrointestinal and urinary systems. This report analyzes the findings in 9 patients with neurogenic orthostatic hypotension and gastrointestinal symptoms. Antral and proximal small intestinal motor dysfunction was demonstrated in all patients: a significant reduction (p = 0.007) in the number of interdigestive motor complexes during 3 h of fasting (mean 0.4 vs. 1.3 controls); absence of gastric component in interdigestive motor complexes observed; incoordination of fasting and fed antral activity; and development of nonpropagating bursts of phase III-like activity in the intestine that were of at least 2-min duration, high amplitude and frequency, and associated with tonic elevations in baseline pressure. These motor abnormalities may provide a potential means for the diagnosis of impaired autonomic supply to the upper gut.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Later stages of amyloidosis may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle.
“Manometric studies suggest that early disease can manifest with motor incoordination consistent with neural involvement, whereas later stages may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle (Battle et al., 1979; Camilleri et al., 1985; Rubinow et al., 1983).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Camilleri et al., 1985
The Discussion (page unavailable) says neural involvement may affect the gut before muscle infiltration in primary amyloidosis and describes very low-amplitude activity as a feature of myogenic pseudoobstruction. But the authors say their patients with amyloidosis showed none of those myogenic features; they did not observe low-amplitude contractions in later-stage amyloidosis. (LLM, conf=0.85)
Experimental — accuracy not yet measuredManometric studies suggest that early amyloidosis can manifest with motor incoordination consistent with neural involvement.
“Manometric studies suggest that early disease can manifest with motor incoordination consistent with neural involvement, whereas later stages may show low-amplitude contractions reflecting myopathic infiltration of smooth muscle (Battle et al., 1979; Camilleri et al., 1985; Rubinow et al., 1983).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Camilleri et al., 1985
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vantrappen, G., Janssens, J., Hellemans, J., & Ghoos, Y. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108740 · Cited by 815 · see citing works
Thomas, J. E., Schirger, A., Fealey, R. D., & Sheps, S. G. (1981) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(26)01416-3 · Cited by 61 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 11
- Polinsky RJ, Kopin IG, Ebert MH, Weise V. Pharmacologic distinction of different orthostatic hypotension syndromes. Neurology (NY) 1981;31:1-7.
- Shy GM, Drager GA. A neurological syndrome associated with orthostatic hypotension: a clinico-pathological study. Arch Neural 1960;2:511-27.
- Khurana RK, Nelson E, Azzarelli B, Garcia JH. Shy-Drager syndrome: diagnosis and treatment of cholinergic dysfunc- tion. Neurology (NY] 1980;30:805-9.
- Malagelada J-R, Rees WDW, Mazzotta LJ, Go VLW. Gastric motor abnormalities in diabetic and postvagotomy gastropar- esis: efficacy of metoclopramide and bethanechol. Gastroen- terology 1980;78:286-93.
- Aguayo AJ, Nair CPV, Bray GM. Peripheral nerve abnormali- ties in the Riley-Day syndrome. Arch Nemo1 1971;24:106-16.
- Young RR, Asbury AK, Adams RD, Corbett JL. Pure pan- dysautonomia with recovery. Trans Am Neurol Assoc 1969; 94:355-7.
- Thomashefsky AJ, Horwitz SJ, Feingold MH. Acute autonom- ic neuropathy. Neurology (NY) 1972;22:251-5.
- Wichser J, Vijayam N, Dreyfus PM. Dysautonomia-its signif- icance in neurologic disease. Calif Med 1972;117:28-37.
- Andersen 0, Lindberg J, Modigh K, Reske-Nielsen E. Sub- acute dysautonomia with incomplete recovery. Acta Neurol Stand 1972;48:510-9.
- Low PA, Dyck PJ, Lambert EH, et al. Acute panautonomic neuropathy. Ann Neurol 1983;13:412-7.
- Andrade C. A peculiar form of peripheral neuropathy: famil- ial atypical generalized amyloidosis with special involve- ment of peripheral nerves. Brain 1952;75:408-27.
Cited by
Sorted by citations
Aggarwal, A., Cutts, T. F., Abell, T. L., Cardoso, S., Familoni, B., Bremer, J., & Karas, J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90753-6 · Cited by 297 · see citing works
Gastrointestinal motility disorders in neurologic disease
Camilleri, M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143771 · Cited by 211 · see citing works
Self-citationVassallo, M., Camilleri, M., Caron, B. L., & Low, P. A. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90609-o · Cited by 95 · see citing works
Self-citationAutonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction
Shouman, K., Camilleri, M., & Singer, W. (2026) · Autonomic Neuroscience · doi:10.1016/j.autneu.2026.103474
Self-citation
- Authors
- Camilleri, M., Malagelada, J.-R., Stanghellini, V., Fealey, R. D., & Sheps, S. G.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1985-06
- Volume
- 88
- Issue
- 6
- Pages
- 1852-1859
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1640809646
- Cited by
- 87
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2016: 1 · 2014: 3 · 2012: 1
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Gastroenterological Association
- National Institutes of Health (5r01am026428-06)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- orthostatic hypotension, neurogenic orthostatic hypotension, gastrointestinal motility, small intestine motility, gastric emptying, autonomic dysfunction
- MeSH terms
- Adult, Aged, Autonomic Nervous System Diseases, Duodenum, Eating, Fasting, Female, Gastrointestinal Motility, Humans, Hypotension, Orthostatic, Jejunum, Male, Manometry, Middle Aged, Norepinephrine, Pyloric Antrum, Sweat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
