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Cited by 159Polyamine Metabolism and ApplicationsAnimal Nutrition and PhysiologyClinical Nutrition and Gastroenterology

The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.

Spermine and spermidine induce intestinal maturation in the rat

Dufour, C., Dandrifosse, G., Forget, P., Vermesse, F., Romain, N., Lepoint, P.·1988·Gastroenterology
DOI 10.1016/0016-5085(88)90298-3
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Abstract

In the present study, we aimed to induce precocious intestinal maturation in neonatal rats by the oral administration of polyamines. Groups of 5 rats received either saline, spermidine (10 mumol daily), or spermine (6 mumol daily) orally on the 12th, 13th, and 14th postnatal days. The rats were killed on the 15th postnatal day. After the small bowel was removed, a 1-cm distal ileal segment was removed for histologic examination and the remaining small bowel tissue was homogenized for further biochemical analysis. Polyamine administration was shown to induce structural and biochemical mucosal changes characteristic of postnatal maturation. Lactase, sucrase, and maltase specific activities (micromoles of substrate hydrolyzed per minute per gram of protein) were 80 +/- 10, 10 +/- 3, and 116 +/- 19 for the saline-treated rats; 51 +/- 7, 34 +/- 2, and 315 +/- 37 for the spermidine-treated rats; and 25 +/- 2, 46 +/- 5, and 419 +/- 63 for the spermine-treated rats, respectively. Similar results were obtained with rats, first treated with spermine (6 mumol) on the 7th postnatal day, receiving spermine (6 mumol) daily as described above and killed on the 10th postnatal day. Dose-response experiments performed as reported above in rats whose treatment began on the 12th postnatal day showed that the maturational effects of orally administered spermine are dose-dependent.

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Crossref · 10.1016/0016-5085(88)90298-3

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Metadata

Authors
Dufour, C., Dandrifosse, G., Forget, P., Vermesse, F., Romain, N., & Lepoint, P.
Affiliations
University of Liège (BE)
ORCID
Romain, N.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1988-07
Volume
95
Issue
1
Pages
112-116
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(88)90298-3
OpenAlex
W2171807112
Cited by
158
References
14
Citations by year
2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 1
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
spermine, spermidine, polyamines, intestinal maturation, postnatal development, ileum, lactase, sucrase, maltase, brush border enzymes, neonatal rats, dose-response relationship
MeSH terms
Age Factors, Animals, Disaccharidases, DNA, Dose-Response Relationship, Drug, Intestinal Mucosa, Intestines, Proteins, Putrescine, Rats, Inbred Strains, Spermidine, Spermine, Rats

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