The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.
Spermine and spermidine induce intestinal maturation in the rat
Abstract
In the present study, we aimed to induce precocious intestinal maturation in neonatal rats by the oral administration of polyamines. Groups of 5 rats received either saline, spermidine (10 mumol daily), or spermine (6 mumol daily) orally on the 12th, 13th, and 14th postnatal days. The rats were killed on the 15th postnatal day. After the small bowel was removed, a 1-cm distal ileal segment was removed for histologic examination and the remaining small bowel tissue was homogenized for further biochemical analysis. Polyamine administration was shown to induce structural and biochemical mucosal changes characteristic of postnatal maturation. Lactase, sucrase, and maltase specific activities (micromoles of substrate hydrolyzed per minute per gram of protein) were 80 +/- 10, 10 +/- 3, and 116 +/- 19 for the saline-treated rats; 51 +/- 7, 34 +/- 2, and 315 +/- 37 for the spermidine-treated rats; and 25 +/- 2, 46 +/- 5, and 419 +/- 63 for the spermine-treated rats, respectively. Similar results were obtained with rats, first treated with spermine (6 mumol) on the 7th postnatal day, receiving spermine (6 mumol) daily as described above and killed on the 10th postnatal day. Dose-response experiments performed as reported above in rats whose treatment began on the 12th postnatal day showed that the maturational effects of orally administered spermine are dose-dependent.
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“Oral administration of polyamines enhances the development and maintenance of the intestinal mucosa and resident immune cells (Buts et al., 1993; Dufour et al., 1988; Löser et al., 1999; Pérez-Cano et al., 2010).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Dufour et al., 1988
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Cites
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Assay of intestinal disaccharidases
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Influence of Epidermal Growth Factor on the Development of Suckling Mouse Intestinal Mucosa
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Developmental physiology: Hard-wired local triggering of intestinal enzyme expression
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Role of Milk-Borne Factors in Weaning and Intestinal Development
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Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
“Dufour et al., 1988; Levy et al., 2015; Pérez-Cano et al., 2010; Wang et al., 1997; Zhang et al., 1999 Gut Bacteria ty bile l Inhibit NF-kB-dependent transcription of proinflammatory genes in monocytes, macrophages, dendritic cells.”
BackgroundToxicological effects of dietary biogenic amines.
Ladero, V., Calles-Enriquez, M., Fernandez, M., & A. Alvarez, M. (2010) · Current Nutrition & Food Science · doi:10.2174/157340110791233256 · Cited by 538
Biological significance of dietary polyamines
Larqué, E., Molina, M. S., & Zamora, S. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.006 · Cited by 311
Tovar‐Ramírez, D., Zambonino‐Infante, J., Cahu, C. L., Gatesoupe, F.-J., Vázquez‐Juárez, R., & Lésel, R. (2002) · Aquaculture · doi:10.1016/s0044-8486(01)00650-0 · Cited by 277
Metadata
- Authors
- Dufour, C., Dandrifosse, G., Forget, P., Vermesse, F., Romain, N., & Lepoint, P.
- Affiliations
- University of Liège (BE)
- ORCID
- Romain, N.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1988-07
- Volume
- 95
- Issue
- 1
- Pages
- 112-116
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2171807112
- Cited by
- 158
- References
- 14
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- spermine, spermidine, polyamines, intestinal maturation, postnatal development, ileum, lactase, sucrase, maltase, brush border enzymes, neonatal rats, dose-response relationship
- MeSH terms
- Age Factors, Animals, Disaccharidases, DNA, Dose-Response Relationship, Drug, Intestinal Mucosa, Intestines, Proteins, Putrescine, Rats, Inbred Strains, Spermidine, Spermine, Rats
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