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Effect of ω-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer
Open accessAbstract
The effects of 12 weeks of omega-3 fatty acid supplementation on rectal mucosal proliferation were assessed with [3H]thymidine autoradiography in a double-blind, placebo-controlled study of 20 patients with sporadic adenomatous colorectal polyps. In the group of 10 that received fish oil containing eicosapentaenoic acid (4.1 g/day) and docosahexaenoic acid (3.6 g/day), the mean percentage of replicative "S"-phase cells in the upper part of colonic crypts (considered a reliable marker of colon cancer risk) significantly dropped from the baseline level after only 2 weeks of treatment and remained lower throughout the study period; no change in upper-crypt labeling was observed in the 10 placebo patients. Rectal mucosal eicosapentaenoic acid content increased in fish oil patients, whereas arachidonic acid levels decreased. The fish oil-induced kinetic changes represent contraction of the proliferative compartment to the levels of a low-risk population and may be related to omega-3 fatty acid effects on the arachidonic prostaglandin pathway. In this short-term trial, fish oil appeared to exert a rapid effect that may protect high-risk subjects from colon cancer.
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Citations
Cited by
Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms
Larsson, S. C., Kumlin, M., Ingelman-Sundberg, M., & Wolk, A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.935 · Cited by 950
Bostick, R. M., Potter, J. D., Kushi, L. H., Sellers, T. A., Steinmetz, K. A., McKenzie, D. R., Gapstur, S. M., & Folsom, A. R. (1994) · Cancer Causes & Control · doi:10.1007/bf01830725 · Cited by 494
Wada, M., DeLong, C. J., Hong, Y. H., Rieke, C. J., Song, I., Sidhu, R. S., Yuan, C., Warnock, M., Schmaier, A. H., Yokoyama, C., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703169200 · Cited by 400
Fat, fish, fish oil and cancer
Caygill, C., Charlett, A., & Hill, M. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.332 · Cited by 310
Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling
Norris, P. C., & Dennis, E. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200189109 · Cited by 193
Metadata
- Authors
- Anti, M., Marra, G., Armelao, F., Bartoli, G. M., Ficarelli, R., Percesepe, A., De Vitis, I., Maria, G., Sofo, L., Rapaccini, G. L., Gentiloni, N., Piccioni, E., & Miggiano, G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 103
- Issue
- 3
- Pages
- 883-891
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2165643695
- Cited by
- 204
- References
- 0
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Anti, M., Marra, G., Armelao, F., Bartoli, G. M., Ficarelli, R., Percesepe, A., De Vitis, I., Maria, G., Sofo, L., Rapaccini, G. L., Gentiloni, N., Piccioni, E., & Miggiano, G. (1992). Effect of ω-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology. https://doi.org/10.1016/0016-5085(92)90021-p
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