The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Gut lavage fluid protein concentrations: Objective measures of disease activity in inflammatory bowel disease
Abstract
Background Fluid obtained by whole gut lavage normally contains traces of immunoglobulin (Ig) G, albumin, and alpha-1-antitrypsin; higher concentrations have been found in patients with inflammatory bowel disease (IBD).Methods In a prospective study, 53 lavages were performed in 45 IBD patients (27 Crohn's disease, 18 ulcerative colitis), in whom disease activity was simultaneously assessed by Crohn's Disease Activity Index or Powell Tuck index. Concentration of IgG in lavage fluid was measured by enzyme-linked immunosorbent assay, and of albumin and alpha-1-antitrypsin by immunoturbidimetry.Results For IgG, concentrations in lavage fluid correlated closely with activity indices: in Crohn's disease, r = 0.723 (P < 0.0001), in ulcerative colitis, r = 0.714 (P < 0.0001). Results for albumin and alpha-1-antitrypsin concentrations were similar to those for IgG, but they were less sensitive in detecting active disease. However, this method cannot be used as a diagnostic test for IBD; normal results were obtained for IgG in 6 (all inactive) of 42 lavages in patients who had unequivocal radiological or endoscopic abnormalities.Conclusions Assay of protein concentrations in gut lavage fluid is a simple, objective means of grading disease activity in patients with IBD; its potential uses are likely to be in the evaluation of complex cases and in clinical trials.
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“Other objective measures associated with disease activity for IBD such as fecal calprotectin 31 , gut permeability 32 or gut lavage fluid protein have high sensitivity for presence or absence of active disease 33 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [33]
Citations
Cites
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Serum levels of C‐reactive protein in Crohn's disease and ulcerative colitis
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Intestinal clearance of α1-antitrypsin
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Cited by
The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity
Clara, I., Lix, L. M., Walker, J. R., Graff, L. A., Miller, N., Rogala, L., Rawsthorne, P., & Bernstein, C. N. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.197 · Cited by 119
Metadata
- Authors
- Choudari, C. P., O'Mahony, S., Brydon, G., Mwantembe, O., & Ferguson, A.
- Affiliations
- Western General Hospital (GB)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 104
- Issue
- 4
- Pages
- 1064-1071
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W246570585
- Cited by
- 71
- References
- 33
- Citations by year
- 2025: 1 · 2022: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- inflammatory bowel disease, disease activity assessment, IgG, albumin, alpha-1-antitrypsin, Crohn's disease, ulcerative colitis, CDAI
- MeSH terms
- Adult, Aged, Aged, 80 and over, alpha 1-Antitrypsin, Colitis, Ulcerative, Crohn Disease, Digestive System, Electrolytes, Female, Gastric Lavage, Humans, Immunoglobulin G, Male, Middle Aged, Polyethylene Glycols, Proteins, Serum Albumin, Solutions
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