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Cited by 71Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeMicroscopic Colitis

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Gut lavage fluid protein concentrations: Objective measures of disease activity in inflammatory bowel disease

Choudari, Chintamaneni P., O'Mahony, Seamus, Brydon, Gordon, Mwantembe, Obedy, Ferguson, Anne·1993·Gastroenterology
DOI 10.1016/0016-5085(93)90275-h
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Abstract

Background Fluid obtained by whole gut lavage normally contains traces of immunoglobulin (Ig) G, albumin, and alpha-1-antitrypsin; higher concentrations have been found in patients with inflammatory bowel disease (IBD).Methods In a prospective study, 53 lavages were performed in 45 IBD patients (27 Crohn's disease, 18 ulcerative colitis), in whom disease activity was simultaneously assessed by Crohn's Disease Activity Index or Powell Tuck index. Concentration of IgG in lavage fluid was measured by enzyme-linked immunosorbent assay, and of albumin and alpha-1-antitrypsin by immunoturbidimetry.Results For IgG, concentrations in lavage fluid correlated closely with activity indices: in Crohn's disease, r = 0.723 (P < 0.0001), in ulcerative colitis, r = 0.714 (P < 0.0001). Results for albumin and alpha-1-antitrypsin concentrations were similar to those for IgG, but they were less sensitive in detecting active disease. However, this method cannot be used as a diagnostic test for IBD; normal results were obtained for IgG in 6 (all inactive) of 42 lavages in patients who had unequivocal radiological or endoscopic abnormalities.Conclusions Assay of protein concentrations in gut lavage fluid is a simple, objective means of grading disease activity in patients with IBD; its potential uses are likely to be in the evaluation of complex cases and in clinical trials.

Overview

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Crossref · 10.1016/0016-5085(93)90275-h

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33 of 33 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Choudari, C. P., O'Mahony, S., Brydon, G., Mwantembe, O., & Ferguson, A.
Affiliations
Western General Hospital (GB)
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1993-04
Volume
104
Issue
4
Pages
1064-1071
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(93)90275-h
OpenAlex
W246570585
Cited by
71
References
33
Citations by year
2025: 1 · 2022: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
5.05
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords
inflammatory bowel disease, disease activity assessment, IgG, albumin, alpha-1-antitrypsin, Crohn's disease, ulcerative colitis, CDAI
MeSH terms
Adult, Aged, Aged, 80 and over, alpha 1-Antitrypsin, Colitis, Ulcerative, Crohn Disease, Digestive System, Electrolytes, Female, Gastric Lavage, Humans, Immunoglobulin G, Male, Middle Aged, Polyethylene Glycols, Proteins, Serum Albumin, Solutions

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.