The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Uptake and transport of macromolecules by the intestine: Possible role in clinical disorders (an update)
Abstract
The intestine is exposed to a wide variety of macromolecules. Because macromolecules are antigenic, mechanisms have evolved in the gastrointestinal tract to regulate their absorption. Macromolecular uptake can be beneficial in delivering essential factors for growth and in sampling the antigenic milieu of the gastrointestinal tract. Specific transport mechanisms exist to execute this physiological absorption. However, inappropriate and uncontrolled antigen transport may occur in disease states or as a prelude to disease states in the gastrointestinal tract. Such transport may result in immune responses that are harmful. This review examines physiological transport of macromolecules through epithelia and through M cells. It also considers uncontrolled transport and its relation to disease states. The review concludes with an examination of the interrelationship between antigen transport and an altered immune system in the establishment of gastrointestinal disease.
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Citations
Cites
An Fc receptor structurally related to MHC class I antigens
Simister, N. E., & Mostov, K. E. (1989) · Nature · doi:10.1038/337184a0 · Cited by 729
Neutra, M., Phillips, T., Mayer, E., & Fishkind, D. (1987) · Cell and Tissue Research · doi:10.1007/bf00215747 · Cited by 253
Cited by
Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398
Probiotics: effects on immunity
Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H., & Salminen, S. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.444s · Cited by 1,019
Probiotics: an overview of beneficial effects
Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020620607611 · Cited by 1,013
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927
Oral tolerance to food protein
Pabst, O., & Mowat, A. M. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.4 · Cited by 656
Metadata
- Authors
- Sanderson, I. R., & Walker, W. A.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1993-02
- Volume
- 104
- Issue
- 2
- Pages
- 622-639
- ISSN
- 0016-5085
- OpenAlex
- W1646658765
- Cited by
- 474
- References
- 2
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sanderson, I. R., & Walker, W. A. (1993). Uptake and transport of macromolecules by the intestine: Possible role in clinical disorders (an update). Gastroenterology. https://doi.org/10.1016/0016-5085(93)90436-g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
