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Cited by 40Sexual Differentiation and DisordersNeuroendocrine regulation and behaviorGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Fetal effects on sexual behavior and aggression in young and old female mice treated with estrogen and testosterone

Rines, Jane P, vom Saal, Frederick S·1984·Hormones and Behavior
DOI 10.1016/0018-506x(84)90037-0
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Abstract

During fetal life female mice (Mus musculus) that develop between two male fetuses (2M females) have higher blood concentrations of testosterone than do females that do not develop next to a male fetus (0M females). In the first experiment reported here, sexual receptivity and sexual attractiveness to males were examined in young (5 month old) and old (17 month old) ovariectomized, estrogen- and progesterone-treated 0M and 2M female mice that were placed in like-age pairs with a male. Most males inseminated the 0M female prior to inseminating the 2M female regardless of age. In addition, 0M females were more likely to exhibit lordosis when mounted than were 2M females. When the same young females were 9 months of age and the old females were 21 months of age, they were treated with testosterone and again placed together in pairs along with a sexually receptive female. Young 2M females exhibited more aggression toward the testosterone-treated female partner, and also exhibited more mounting of the receptive female, than did young 0M females. But, both old 0M and old 2M females were highly aggressive and exhibited mounting. An increase in sensitivity to the effects of testosterone on behavior thus occurs during aging in 0M females, which are relatively insensitive to testosterone in young adulthood. In contrast, when treated with estrogen and progesterone, 0M females were more attractive to males and were more sexually receptive than 2M females regardless of age.

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Crossref · 10.1016/0018-506x(84)90037-0

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  • Among mice, rabbits, and gerbils, 0M females demonstrate higher attractiveness to males than 2M females.

    “Among mice, rabbits, and gerbils, 0M females (that developed under lower prenatal testosterone) demonstrate higher attractiveness to males than 2M females, across multiple studies employing a range of mate choice paradigms (Clark & Galef, 1998; Rines & vom Saal, 1984; vom Saal & Bronson, 1978, 1980a).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Rines & vom Saal, 1984

Citations

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Research works printed but not linked: 24

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  2. Barkley, 1977, Testosterone-induced aggression in adult female mice, Horm. Behav., 8, 208, 10.1016/0018-506X(77)90038-1 · DOI
  3. Baum, 1979, Differentiation of coital behavior in mammals: A comparative analysis, Neurosci. Biobehav. Rev., 3, 265, 10.1016/0149-7634(79)90013-7 · DOI
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  8. Edwards, 1971, Early androgen treatment and male and female sexual behavior in mice, Horm. Behav., 2, 49, 10.1016/0018-506X(71)90037-7 · DOI
  9. Finch, 1980, Studies on ovarian-hypothalamic-pituitary interactions during reproductive agina in C57BL/6J mice, Peptides, 1, 163, 10.1016/0196-9781(80)90114-X · DOI
  10. Gibori, 1979, Ovarian and serum concentrations of androgen throughout pregnancy in the rat, Biol. Reprod., 21, 53, 10.1095/biolreprod21.1.53 · DOI
  11. Gladue, 1978, Androgenic influences on feminine sexual behavior in male and female rats: Defeminization blocked by prenatal antiandrogen treatment, Endocrinology, 103, 1702, 10.1210/endo-103-5-1702 · DOI
  12. Gorski, 1979, The neuroendocrinology of reproduction: An overview, Biol. Reprod., 20, 111, 10.1093/biolreprod/20.1.111 · DOI
  13. Gray, 1980, Estrogen and testosterone sensitivity of middle-aged female rats in the regulation of LH, Exp. Geront., 15, 201, 10.1016/0531-5565(80)90025-X · DOI
  14. Hollinka, 1981, Efficiency of mating in C57BL/6J female mice as a function of age and previous parity, Exp. Gerontol., 16, 393, 10.1016/0531-5565(81)90060-7 · DOI
  15. Huber, 1980, Sexual activity of aged male mice: Correlation with level of arousal, physical endurance, pathological status, and ejaculatory capacity, Biol. Reprod., 23, 305, 10.1095/biolreprod23.2.305 · DOI
  16. Lu, 1979, Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reproductive states, Biol. Reprod., 21, 193, 10.1095/biolreprod21.1.193 · DOI
  17. Mallampati, 1974, Gonadotropins in female rats androgenized by various treatments: Prolactin as an index to hypothalamic damage, Neuroendocrinology, 15, 255, 10.1159/000122316 · DOI
  18. Mugford, 1971, The relationship between endocrine status of female opponents and aggressive behaviour of male mice, Anim. Behav., 19, 153, 10.1016/S0003-3472(71)80150-1 · DOI
  19. Peng, 1977, Lordosis response of senile female rats, Neuroendocrinology, 24, 317, 10.1159/000122718 · DOI
  20. vom Saal, 1981, Variation in phenotype due to random intrauterine positioning of male and female fetuses in rodents, J. Reprod. Fert., 62, 633, 10.1530/jrf.0.0620633 · DOI
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Metadata

Authors
Rines, J. P., & vom Saal, F. S.
Affiliations
University of Missouri (US)
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
1984-06
Volume
18
Issue
2
Pages
117-129
ISSN
0018-506X (ISSN-L)
DOI
10.1016/0018-506x(84)90037-0
OpenAlex
W2001508971
Cited by
40
References
0
Citations by year
2024: 2 · 2021: 3 · 2018: 2 · 2016: 1 · 2012: 1
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Missouri
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords
fetal testosterone, female sexual behavior, aggression, sexual receptivity, sexual attractiveness, lordosis, aging, estrogen, progesterone, ovariectomy, female mice, prenatal androgen exposure
MeSH terms
Age Factors, Aggression, Aging, Animals, Copulation, Estradiol, Female, Fetus, Sexual Behavior, Animal, Testosterone, Mice

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