Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides
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Polymyxin B is a narrow-spectrum antibiotic known to both inhibit LPS signalling and deplete Gram-negative bacteria by binding the lipid A region of LPS.
“polymyxin B (PMB), a narrow-spectrum antibiotic known to both inhibit LPS signalling and deplete Gram-negative bacteria by binding the lipid A region of LPS18.”
From Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses (2025) · cites this paper as [18]
Cites
A New Method for the Extraction of R Lipopolysaccharides
Galanos, C., Luderitz, O., & Westphal, O. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00601.x · Cited by 1,872 · see citing works
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Fractions of lipopolysaccharide from Escherichia coli O111:B4 prepared by two extraction procedures.
Morrison, D., & Leive, L. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41574-3 · Cited by 332 · see citing works
Self-citationRietschel, E., Gotter, H., Luderitz, O., & Westphal, O. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb01899.x · Cited by 241 · see citing works
Skidmore, B. J., Chiller, J. M., Morrison, D. C., et al. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.114.2_part_2.770 · Cited by 238 · see citing works
Self-citationPrevention by polymyxin B of endotoxin lethality in mice
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Bacterial Endotoxins (Part 1 of 2)
Westphal, O. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000231374 · Cited by 156 · see citing works
The mechanism of histamine release from mast cells
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Electron Microscopy of Effect of Polymyxin on Escherichia coli Lipopolysaccharide
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Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B
Morrison, D. C., & Jacobs, D. M. (1976) · Infection and Immunity · doi:10.1128/iai.13.1.298-301.1976 · Cited by 82 · see citing works
Self-citationEndotoxin-induced intravascular coagulation: prevention with polymyxin B sulfate.
Jj, C., & Bm, B. (1971) · PubMed · Cited by 77 · see citing works
Jacobs, D., & Morrison, D. (1975) · The Journal of Experimental Medicine · doi:10.1084/jem.141.6.1453 · Cited by 76 · see citing works
Self-citationWeiser, M. M., & Rothfield, L. I. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)56990-3 · Cited by 71 · see citing works
Activation of Rat Mast Cells by Low Molecular Weight Stimuli
Morrison, D. C., Roser, J. F., Henson, P. M., et al. (1974) · The Journal of Immunology · doi:10.4049/jimmunol.112.2.573 · Cited by 60 · see citing works
Self-citationNeutralization of the Shwartzman reactions by polymyxins B.
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The Initiation of Mast Cell Degranulation: Activation at the Cell Membrane
Morrison, D. C., Roser, J. F., Cochrane, C. G., et al. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.114.3.966 · Cited by 24 · see citing works
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TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
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Yu, L.-X., Yan, H.-X., Liu, Q., Yang, W., Wu, H.-P., Dong, W., Tang, L., Lin, Y., He, Y.-Q., Zou, S.-S., et al. (2010) · Hepatology · doi:10.1002/hep.23845 · Cited by 349 · see citing works
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Fux, A. C., Casonato Melo, C., Michelini, S., Swartzwelter, B. J., Neusch, A., Italiani, P., & Himly, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098395 · Cited by 83 · see citing works
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
Sardar, P., Beresford-Jones, B. S., Xia, W., Shabana, O., Suyama, S., Ramos, R. J. F., Soderholm, A. T., Tourlomousis, P., Kuo, P., Evans, A. C., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-01930-y · Cited by 49 · see citing works
Meng, F., Liu, Y., Nie, T., Tang, C., Lyu, F., Bie, X., Lu, Y., Zhao, M., & Lu, Z. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.00371-22 · Cited by 24 · see citing works
- Authors
- Morrison, D. C., & Jacobs, D. M.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Morrison, David C.
- ORCID
- Jacobs, Diane M.
- Venue
- Immunochemistry
- Publisher
- Elsevier BV
- Published
- 1976-10
- Volume
- 13
- Issue
- 10
- Pages
- 813-818
- ISSN
- 0019-2791 (ISSN-L)
- OpenAlex
- W2120227455
- Cited by
- 819
- References
- 18
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 5 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 17 · 2017: 17 · 2016: 13 · 2015: 21 · 2014: 13 · 2013: 18 · 2012: 23
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- polymyxin B, lipid A, bacterial lipopolysaccharide, cationic peptides, binding stoichiometry
- MeSH terms
- Binding Sites, Centrifugation, Isopycnic, Escherichia coli, Lipids, Lipopolysaccharides, Molecular Weight, Polymyxins, Polysaccharides, Bacterial, Structure-Activity Relationship
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