The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome
Abstract
Polycystic ovarian syndrome (PCOS) appears to be due to a previously unrecognized type of steroidogenic abnormality, one in which hyperandrogenism arises from a regulatory abnormality (dysregulation) rather than from enzyme deficiency. It appears that PCOS typically arises from masculinized regulation of the androgen-forming enzyme (cytochrome P450c17 alpha) within ovarian thecal cells. This may arise by either excessive stimulation by luteinizing hormone (LH) or by escape from desensitization to LH. We review evidence which is compatible with the concept that the latter situation may result from an intrinsic intraovarian flaw in the paracrine feedback mechanism by which thecal androgen biosynthesis is inhibited and that coexistent adrenal 17-ketosteroid hyper-responsiveness to corticotropin (ACTH) may be due to a similar type of dysregulation of adrenocortical P450c17 alpha.
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Cites
Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle
ABRAHAM, G. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-340 · Cited by 436
Expression of Bovine 17α-Hydroxylase Cytochrome P-450 cDNA in Nonsteroidogenic (COS 1) Cells
Zuber, M. X., Simpson, E. R., & Waterman, M. R. (1986) · Science · doi:10.1126/science.3535074 · Cited by 388
VOUTILAINEN, R., TAPANAINEN, J., CHUNG, B.-C., MATTESON, K. J., & MILLER, W. L. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-1-202 · Cited by 253
Clinical and Biological Phenotypes in Late-Onset 21 Hydroxylase Deficiency
DEWAILLY, D., VANTYGHEM-HAUDIQUET, M.-C., SAINSARD, C., BUVAT, J., CAPPOEN, J. P., ARDAENS, K., RACADOT, A., LEFEBVRE, J., & FOSSATI, P. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-418 · Cited by 151
Cited by
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463
Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603
Self-citationPolycystic ovary syndrome: etiology, pathogenesis and diagnosis
Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.217 · Cited by 1,488
(2016) · Dietetic and Nutrition Case Studies · doi:10.1002/9781119163411.ch73 · Cited by 1,013
Nelson, V. L., Legro, R. S., Strauss, J. F., & McAllister, J. M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.6.0311 · Cited by 556
Metadata
- Authors
- Rosenfield, R., Barnes, R., Cara, J., & Lucky, A.
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 1991-03
- Volume
- 34
- Issue
- 3
- Pages
- 286-287
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W2235942812
- Cited by
- 222
- References
- 4
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenfield, R., Barnes, R., Cara, J., & Lucky, A. (1991). Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome. International Journal of Gynecology & Obstetrics. https://doi.org/10.1016/0020-7292(91)90373-d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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