Treatment of polycystic ovarian disease during adolescence with ethinylestradiol/cyproterone acetate versus a D-Tr-6-LHRH analog
Abstract
OBJECTIVE: This study was undertaken to compare the clinical and endocrinological results of two kinds of treatment on adolescents with polycystic ovarian disease (PCOD). METHOD: Forty-five adolescents with PCOD were randomly allocated into two groups, treated either with ethinylestradiol (EE)/cyproterone acetate (group A) or the GnRH analog D-Tr-6-LHRH (group B). RESULT: No significant changes were detected on the body mass index and waist-hip circumference. A significant improvement of hirsutism was noticed in both groups of patients. A normal menstrual period was recorded in group A adolescents while all group B patients became amenorrheic. A favorable decrease of ovarian volume was detected in both groups. LH/FSH ratio and delta 4-androstenedione serum levels were found significantly reduced in both groups in comparison to pre-treatment levels. The comparison between the two groups, after 6 months, showed significantly lower values of LH/FSH ratio in group B cases. CONCLUSION: Both forms of treatment are safe and effective to a various degree for the management of PCOD adolescents.
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Estrogens in the COCPs decrease free androgens by increasing hepatic production of SHBG and decrease ovarian and adrenal androgen production by suppressing LH levels.
“Estrogens in the COCPs decrease free androgens by increasing hepatic production of SHBG and decrease ovarian and adrenal androgen production by suppressing LH levels [203].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [203]
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- Authors
- Creatsas, G., Hassan, E., Deligeoroglou, E., Tolis, G., & Aravantinos, D.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Creatsas, G.
- ORCID
- Hassan, E.
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 1993-08
- Volume
- 42
- Issue
- 2
- Pages
- 147-153
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- OpenAlex
- W2073172468
- Cited by
- 17
- References
- 19
- Citations by year
- 2019: 1 · 2018: 2 · 2016: 1 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- polycystic ovary syndrome, adolescents, GnRH analogues, hirsutism, amenorrhea, menstrual cycle, ovarian volume, LH/FSH ratio, androstenedione, androgen deprivation therapy
- MeSH terms
- Adolescent, Androstenedione, Dehydroepiandrosterone, Delayed-Action Preparations, Drug Therapy, Combination, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Polycystic Ovary Syndrome, Prolactin, Prospective Studies, Sex Hormone-Binding Globulin, Testosterone, Dinoprostone, Triptorelin Pamoate, Cyproterone Acetate, Dehydroepiandrosterone Sulfate
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