The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis *1Part 1. The lipids in the isolated fractions

SMITH, E; SLATER, R

doi:10.1016/0021-9150(72)90036-6

Cited by 115Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis *1Part 1. The lipids in the isolated fractions

SMITH, E, SLATER, R·1972·Atherosclerosis

DOI 10.1016/0021-9150(72)90036-6

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/0021-9150(72)90036-6

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The ECM has a central role in initiation of atherosclerosis, primarily through the interaction between the negatively charged side chains of proteoglycans with positively charged apolipoproteins, which leads to the retention of plasma-derived lipoproteins.
“The ECM has a central role in initiation of atherosclerosis, primarily through the interaction between the negatively charged side chains of proteoglycans (particularly chondroitin sulphate of biglycan and versican and heparin sulphate of perlecan 110 ) with positively charged apolipoproteins (especially apolipoprotein B) , which leads to the retention of plasma-derived lipoproteins 101,111 - as”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [111]

Histochemistry: Theoretical and Applied
(1953) · JAMA · doi:10.1001/jama.1953.02940280072039 · Cited by 7,021 · see citing works
Histological Demonstration of Mucin after Periodic Acid
McManus, J. F. A. (1946) · Nature · doi:10.1038/158202a0 · Cited by 1,218 · see citing works
Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium
Strehler, B. L., Mark, D. D., Mildvan, A. S., & Gee, M. V. (1959) · Journal of Gerontology · doi:10.1093/geronj/14.4.430 · Cited by 342 · see citing works
Lipid in the aortic intima the correlation of morphological and chemical characteristics
Smith, E. B., Evans, P. H., & Downham, M. D. (1967) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(67)80079-6 · Cited by 265 · see citing works
Self-citation
Propylene and Ethylene Glycol as Solvents for Sudan IV and Sudan Black B
Chiffelle, T. L., & Putt, F. A. (1951) · Stain Technology · doi:10.3109/10520295109113178 · Cited by 247 · see citing works
The in vitro Interchange of Cholesterol Between Plasma and Red Cells.
Hagerman, J. A. S., & Gould, R. G. (1951) · Experimental Biology and Medicine · doi:10.3181/00379727-78-19064 · Cited by 225 · see citing works
Quantitative Aspects of Cholesterol Flux in Rabbit Atheromatous Lesions
Newman, H., & Zilversmit, D. B. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)63400-9 · Cited by 199 · see citing works
The Use of Nile Blue in the Examination of Lipoids
Cain, A. J. (1947) · Journal of Cell Science · doi:10.1242/jcs.s3-88.3.383 · Cited by 199 · see citing works
The microtitration of total fatty acids of serum, with notes on the estimation of triglycerides
Albrink, M. J. (1959) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39092-1 · Cited by 186 · see citing works
Pathogenesis and Significance of Hemoceroid and Hyaloceroid, Two Types of Ceroidlike Pigment Found in Human Atheromatous Lesions
Hartroft, W. S. (1953) · Journal of Gerontology · doi:10.1093/geronj/8.2.158 · Cited by 148 · see citing works
ON THE HISTOCHEMISTRY AND ULTRASTRUCTURE OF AGE PIGMENT.
Bl, S. (1964) · PubMed · Cited by 135 · see citing works
"Ceroid" Pigment in Human Tissues.
Pappenheimer, A. M., & Victor, J. (1946) · PubMed · Cited by 131 · see citing works
A histochemical method for the simultaneous demonstration of normal and degenerating myelin
Adams, C. W. M. (1959) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700770240 · Cited by 127 · see citing works
Ethylenic Reaction of Ceroid with Performic Acid and Schiff Reagent
Lillie, R. D. (1952) · Stain Technology · doi:10.3109/10520295209105058 · Cited by 122 · see citing works
Influence of Duration of Cholesterol Feeding on Esterification of Fatty Acids by Cell-Free Preparation of Pigeon Aorta
Clair, R. W. S., Lofland, H. B., & Clarkson, T. B. (1970) · Circulation Research · doi:10.1161/01.res.27.2.213 · Cited by 116 · see citing works
Uptake and Release of Cholesterol by Rabbit Atheromatous Lesions
Newman, H., & Zilversmit, D. B. (1966) · Circulation Research · doi:10.1161/01.res.18.3.293 · Cited by 103 · see citing works
The lipids in raised fatty and fibrous lesions in human aorta
Smith, E. B., Slater, R. S., & Chu, P. (1968) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(68)80097-3 · Cited by 94 · see citing works
Self-citation
A Rigorous Re-Definition of the Piasmal Reaction
Hayes, E. R. (1949) · Stain Technology · doi:10.3109/10520294909139574 · Cited by 54 · see citing works
ISOLATED LIPOFUSCIN GRANULES- A SURVEY OF A NEW FIELD.
Bjoerkerud, S. (1964) · PubMed · Cited by 54 · see citing works
Transfer of cholesterol and cholesteryl esters into wall of rat aorta in vitro
Hashimoto, S., & Dayton, S. (1966) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(66)80038-8 · Cited by 50 · see citing works
Cholesterol ester formation in aortas of cholesterol-fed rabbits
Newman, H., Gray, G. W., & Zilversmit, D. B. (1968) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(68)80037-7 · Cited by 49 · see citing works
The Histochemistry and Ultrastructure of Lipid Pigment in the Adrenal Glands of Aging Mice
Samorajski, T., & Ordy, J. M. (1967) · Journal of Gerontology · doi:10.1093/geronj/22.3.253 · Cited by 46 · see citing works
The Incidence of Acid-Fast Pigment (Ceroid) in Aortic Atherosclerosis
Burt, R. C. (1952) · American Journal of Clinical Pathology · doi:10.1093/ajcp/22.2.135 · Cited by 46 · see citing works
The Bi-directional Transfer of Cholesterol in Normal Aorta, Fatty Streaks, and Atheromatous Plaques
Lofland, H. B., & Clarkson, T. B. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-133-34394 · Cited by 35 · see citing works
LIPIDS CARRIED BY Sf 0-12 LIPOPROTEIN IN NORMAL AND HYPERCHOLESTEROLÆMIC SERUM
Smith, E. B. (1962) · The Lancet · doi:10.1016/s0140-6736(62)90402-6 · Cited by 33 · see citing works
Self-citation
The effect of short-term cholesterol feeding on the development of aortic atheromatosis in the rabbit
Albrecht, W., & Schüler, W. (1965) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(65)80071-0 · Cited by 33 · see citing works
An Examination of Baker’s Acid Haematein Test for Phospholipines
Cain, A. J. (1947) · Journal of Cell Science · doi:10.1242/jcs.s3-88.4.467 · Cited by 31 · see citing works
THE FINE STRUCTURE OF CEROID IN HUMAN ATHEROMA
Györkey, F., Shimamura, T., & O’Neal, R. M. (1967) · Journal of Histochemistry & Cytochemistry · doi:10.1177/15.12.732 · Cited by 30 · see citing works
An Ultraviolet-Schiff Reaction for Unsaturated Lipids
Belt, W. D., & Hayes, E. R. (1956) · Stain Technology · doi:10.3109/10520295609113789 · Cited by 28 · see citing works
The distribution of phospholipid within macrophages in human atheromatous plaques
Dunnigan, M. G. (1964) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(64)80034-x · Cited by 26 · see citing works
Phosphomolybdic acid as a staining reagent for lipids.
Bh, L., Ll, U., & Whipple, A. O. (1952) · PubMed · Cited by 23 · see citing works
The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis *1Part 2. Studies on “nile blue” cells
Slater, R., & SMITH, E. (1972) · Atherosclerosis · doi:10.1016/0021-9150(72)90037-8 · Cited by 15 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227 · see citing works
Vascular smooth muscle cells in atherosclerosis
Basatemur, G. L., Jørgensen, H. F., Clarke, M. C. H., Bennett, M. R., & Mallat, Z. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0227-9 · Cited by 1,099 · see citing works
Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis
Yahagi, K., Kolodgie, F. D., Otsuka, F., Finn, A. V., Davis, H. R., Joner, M., & Virmani, R. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.164 · Cited by 548 · see citing works
Pathophysiology of Atherosclerosis Plaque Progression
Sakakura, K., Nakano, M., Otsuka, F., Ladich, E. R., Kolodgie, F. D., & Virmani, R. (2013) · Heart Lung and Circulation · doi:10.1016/j.hlc.2013.03.001 · Cited by 471 · see citing works
The Relationship Between Plasma and Tissue Lipids in Human Atherosclerosis
Smith, E. B. (1974) · Advances in lipid research · doi:10.1016/b978-0-12-024912-1.50008-9 · Cited by 355 · see citing works
Self-citation
Structure and interactions of lipids in human plasma low density lipoproteins.
Deckelbaum, R. J., Shipley, G. G., & SMALL, D. M. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32781-3 · Cited by 353 · see citing works
Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques.
Katz, S. S., Shipley, G. G., & SMALL, D. M. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108450 · Cited by 349 · see citing works
Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans
Nakashima, Y., Wight, T. N., & Sueishi, K. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn099 · Cited by 297 · see citing works
Physical-Chemical Basis of Lipid Deposition in Atherosclerosis
SMALL, D. M., & Shipley, G. G. (1974) · Science · doi:10.1126/science.185.4147.222 · Cited by 293 · see citing works
Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins
Curcio, C. A., Johnson, M., Huang, J.-D., & Rudolf, M. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.08.001 · Cited by 286 · see citing works
“399 ration; apo, apolipoprotein; BlamD, basal laminar deposit; BlinD, basal linear deposit; BrM, Bruch’s membrane; CAD, fied cholesterol; LDL, low density lipoprotein; MTP, microsomal triglyceride transfer protein; PL, phospholipid; RPE, sterified cholesterol; VLDL, very low density lipoprotein. ology, 700 South 18th…”
Influential
Mechanical properties of model atherosclerotic lesion lipid pools.
Loree, H., Tobias, B. J., Gibson, L. J., Kamm, R., Small, D., & Lee, R. T. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.2.230 · Cited by 294 · see citing works
Development of the Lipid-Rich Core in Human Atherosclerosis
Guyton, J. R., & Klemp, K. F. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.1.4 · Cited by 236 · see citing works
RELATIONSHIP BETWEEN LOW-DENSITY LIPOPROTEIN IN AORTIC INTIMA AND SERUM-LIPID LEVELS
Smith, E. B., & Slater, R. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90122-5 · Cited by 205 · see citing works
Self-citation
Chemical composition and physical state of lipid deposits in atherosclerosis
Lundberg, B. B. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90087-5 · Cited by 190 · see citing works
Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis.
SMALL, D. M., Bond, M. G., Waugh, D., Prack, M. M., & Sawyer, J. K. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111366 · Cited by 190 · see citing works
Cellular Mechanisms for Lipid Deposition in Atherosclerosis
Bleich, H. L., Boro, E. S., & SMALL, D. M. (1977) · New England Journal of Medicine · doi:10.1056/nejm197710202971608 · Cited by 153 · see citing works
Terrein: a new melanogenesis inhibitor and its mechanism
Park, S. H., Kim, D. S., Kim, W. K., Ryoo, I. J., Lee, D. H., Huh, C., Youn, S. W., YOO, I. ‐., & Park, K. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4341-3 · Cited by 138 · see citing works
Development of the atherosclerotic core region. Chemical and ultrastructural analysis of microdissected atherosclerotic lesions from human aorta.
Guyton, J. R., & Klemp, K. F. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.8.1305 · Cited by 134 · see citing works
Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression.
Rapp, J. H., We, C., Lin, D. S., Inahara, T., & Porter, J. M. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37883-4 · Cited by 130 · see citing works
Factors influencing the accumulation in fibrous plaques of lipid derived from low density lipoprotein
Smith, E. B., Keen, G. A., & GRANT, A. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90087-y · Cited by 115 · see citing works
Self-citation
Assay, Kinetics, and Lysosomal Localization of an Acid Cholesteryl Esterase in Rabbit Aortic Smooth Muscle Cells
Takano, T., Black, W. J., Peters, T. J., & Duve, C. D. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42120-0 · Cited by 108 · see citing works
Mechanical properties of human atherosclerotic intima tissue
Akyildiz, A. C., Speelman, L., & Gijsen, F. J. H. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.01.019 · Cited by 104 · see citing works
“A lipid pool in an atherosclerotic plaque mainly consists of phospholipids, cholesterol esters, cholesterol crystals and other lipids (Smith and Slater, 1972).”
Background
Vitamin E Combined With Selenium Inhibits Atherosclerosis in Hypercholesterolemic Rabbits Independently of Effects on Plasma Cholesterol Concentrations
Schwenke, D. C., & Behr, S. R. (1998) · Circulation Research · doi:10.1161/01.res.83.4.366 · Cited by 98 · see citing works
Atherosclerosis and the coagulation system
Thompson, W. D., & Smith, E. B. (1989) · The Journal of Pathology · doi:10.1002/path.1711590203 · Cited by 92 · see citing works
Self-citation
Macrophage foam cells and atherosclerosis
Howard, S. K. (2001) · Frontiers in bioscience · doi:10.2741/kruth · Cited by 89 · see citing works
Clonal characteristics of fibrous plaques and fatty streaks from human aortas.
Pearson, T. A., Wang, B. A., Solez, K., & Heptinstall, R. H. (1975) · PubMed Central · Cited by 89 · see citing works
Adipocytic Differentiation and Liver X Receptor Pathways Regulate the Accumulation of Triacylglycerols in Human Vascular Smooth Muscle Cells
Davies, J. D., Carpenter, K. L. H., Challis, I. R., Figg, N., McNair, R., Proudfoot, D., Weissberg, P. L., & Shanahan, C. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410075200 · Cited by 86 · see citing works
Isolation and and partial characterization of the lipid phases of human atherosclerotic plaques.
Katz, S. S., & SMALL, D. M. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43457-6 · Cited by 83 · see citing works
Localization of low-density lipoproteins in atherosclerotic lesions from human normolipemics employing a purified fluorescent-labeled antibody
Hoff, H. F., Jackson, R. L., Mao, S. J. T., & Gotto, A. M. (1974) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(74)90205-0 · Cited by 76 · see citing works
Cholesteryl ester-rich inclusions from human aortic fatty streak and fibrous plaque lesions of atherosclerosis. I. Crystalline properties, size and internal structure.
Yoshiya, H. A. T. A., Hower, J., & Insull, W. (1974) · PubMed Central · Cited by 75 · see citing works
Fibrinogen and low density lipoprotein in the development of cerebral atherosclerosis
D, S. S. M., & Tanaka, K. (1979) · Atherosclerosis · doi:10.1016/0021-9150(79)90133-3 · Cited by 73 · see citing works
Pathologic intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells
Nakagawa, K., & Nakashima, Y. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.03.039 · Cited by 70 · see citing works
High‐resolution H NMR spectral signature from human atheroma
Pearlman, J. D., Zajíček, J., Merickel, M., Carman, C. S., Ayers, C. R., Brookeman, J. R., & Brown, M. F. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910070303 · Cited by 67 · see citing works
Novel Lipidomic Biomarkers in Hyperlipidemia and Cardiovascular Diseases: An Integrative Biology Analysis
Rai, S., & Bhatnagar, S. (2017) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0178 · Cited by 61 · see citing works
“The formation of AP starts from fatty streaks, which consist mainly of cellular components (e.g., foam cells) (Lang and Insull, 1970; Otsuka et al., 2014; Smith and Slater, 1972; Smith et al., 1968).”
Interaction of native and cell-modified low density lipoprotein with collagen gel.
Hoover, G. A., McCormick, S., & Kalant, N. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.5.525 · Cited by 57 · see citing works
Histochemical detection of esterified cholesterol within human atherosclerotic lesions using the fluorescent probe filipin
Kruth, H. S. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90175-8 · Cited by 54 · see citing works
Molecular interactions in human atherosclerotic plaques.
Eb, S. (1977) · PubMed Central · Cited by 54 · see citing works
Mechanisms of cholesterol accumulation in the arterial wall
Zilversmit, D. B. (1975) · The American Journal of Cardiology · doi:10.1016/0002-9149(75)90840-1 · Cited by 53 · see citing works
A study of atherosclerosis regression in Macaca mulatta: III. Chemical changes in arteries from animals with atherosclerosis induced for 19 months and regressed for 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl.
Wagner, W. D., Clair, R. W. S., Clarkson, T. B., & Connor, J. R. (1980) · PubMed Central · Cited by 51 · see citing works
Lipid deposits in ageing human arteries, tendons and fascia
Adams, C. W. M., BAYLISS, O. B., Baker, R. W. R., Abdulla, Y. H., & Hunter-Craig, C. J. (1974) · Atherosclerosis · doi:10.1016/s0021-9150(74)80007-9 · Cited by 46 · see citing works
Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis
Perrey, S., Legendre, C., Matsuura, A., Guffroy, C., Binet, J. L., Ohbayashi, S., Tanaka, T., Ortuno, J. C., Matsukura, T., Laugel, T., et al. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00599-2 · Cited by 46 · see citing works
“Aortic lipids were extracted with organic solvents (ether:ethanol 1:3 v:v, then twice with chloroform: methanol, 2:1 v:v) according to Smith and Slater [ 25 ].”
Method
Regulation of serum-induced lipid accumulation in human monocyte-derived macrophages by interferon- γ . Correlations with apolipoprotein E production, lipoprotein lipase activity and LDL receptor-related protein expression
Garner, B., Baoutina, A., Dean, R. T., & Jessup, W. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)05979-5 · Cited by 45 · see citing works
Interactions of cholesterol esters with phospholipids: cholesteryl myristate and dimyristoyl lecithin.
Janiak, M. J., SMALL, D. M., & Shipley, G. G. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40630-3 · Cited by 44 · see citing works
Interaction of collagen with the lipids of tendon xanthomata.
Tall, A. R., SMALL, D. M., & Lees, R. S. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109196 · Cited by 42 · see citing works
Transport of Material Between Blood and Wall in Arteries
Caro, C. G. (1973) · Novartis Foundation symposium · doi:10.1002/9780470719954.ch6 · Cited by 42 · see citing works
Comparative primate atherosclerosis
Wagner, W. D., & Clarkson, T. B. (1975) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(75)90009-x · Cited by 38 · see citing works
Acid Glycosaminoglycan, Collagen and Elastin Content of Normal Artery, Fatty Streaks and Plaques
Smith, E. B. (1974) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3243-5_6 · Cited by 38 · see citing works
Self-citation
The binary phase diagram of lecithin and cholesteryl linolenate
Loomis, C. R., Janiak, M. J., SMALL, D. M., & Shipley, G. G. (1974) · Journal of Molecular Biology · doi:10.1016/0022-2836(74)90021-7 · Cited by 37 · see citing works
Cholesterol Deposition in Atherosclerotic Lesions
Kruth, H. S. (1997) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4615-5901-6_12 · Cited by 34 · see citing works
Accumulation of Plasma-Derived Lipids in the Lipid Core and Necrotic Core of Human Atheroma: Imaging Mass Spectrometry and Histopathological Analyses
Nakagawa, K., Tanaka, M., Hahm, T., Nguyen, H.-N., Matsui, T., Chen, Y.-X., & Nakashima, Y. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316154 · Cited by 32 · see citing works
Chemistry and Biochemistry of Unsaturated Fatty Acids
Kunau, W. (1976) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197600611 · Cited by 32 · see citing works
Lipids and Low‐Density Lipoproteins in Intima in Relation to Its Morphological Characteristics
Smith, E. B., & Slater, R. S. (1973) · Novartis Foundation symposium · doi:10.1002/9780470719954.ch3 · Cited by 32 · see citing works
Self-citation
Spatial Distributions of Lipids in Atherosclerosis of Human Coronary Arteries Studied by Time-of-Flight Secondary Ion Mass Spectrometry
Lehti, S., Sjövall, P., Käkelä, R., Mäyränpää, M. I., Kovanen, P. T., & Öörni, K. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.01.026 · Cited by 31 · see citing works
Long-Term Effects of CCK-Agonist and -Antagonist on Food Intake and Body Weight in Zucker Lean and Obese Rats
Meereis-Schwanke, K., Klonowski-Stumpe, H., Herberg, L., & Niederau, C. (1998) · Peptides · doi:10.1016/s0196-9781(97)00261-1 · Cited by 30 · see citing works
The structural stability of low-density lipoprotein
Mateu, L., Ávila, E. E. L., Camejo, G., León, V., & Liscano, N. (1984) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(84)90182-6 · Cited by 30 · see citing works
Cholesterol accumulation in aortic smooth muscle cells exposed to low density lipoproteins. Contribution of free cholesterol transfer.
Slotte, J. P., Chait, A., & Bierman, E. L. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.6.750 · Cited by 27 · see citing works
Spectrophotometric determination of hydroxyproline in connective tissue on the nanogram level
Bondjers, G., & Björkerud, S. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90054-7 · Cited by 27 · see citing works
Incorporation and localisation of ganglioside GM3 in human intimal atherosclerotic lesions
Bobryshev, Y. V., Lord, R. S. A., Golovanova, N. K., Gracheva, E. V., Zvezdina, N. D., SADOVSKAYA, V. L., & Prokazova, N. V. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00044-6 · Cited by 26 · see citing works
Lipid analysis and fatty acid profiles of individual arterial atherosclerotic plaques
McGrath, L. T., & Elliott, R. J. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90456-j · Cited by 24 · see citing works
Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia.
Sugiyama, N., Marcovina, S. M., Gown, A. M., Seftel, H. C., Joffe, B. I., & Chait, A. (1992) · PubMed Central · Cited by 24 · see citing works
Degranulation of cutaneous mast cells induces transendothelial transport and local accumulation of plasma LDL in rat skin in vivo
Ma, H., & Kovanen, P. T. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37162-5 · Cited by 23 · see citing works
Atherosclerosis: Pathology, pathogenesis, and role of risk factors
Grundy, S. M. (1983) · Disease-a-Month · doi:10.1016/0011-5029(83)90031-7 · Cited by 23 · see citing works
Chemie und Biochemie ungesättigter Fettsäuren
Kunau, W. (1976) · Angewandte Chemie · doi:10.1002/ange.19760880402 · Cited by 22 · see citing works
Selective Increase in Cholesterol at Atherosclerosis-Susceptible Aortic Sites After Short-term Cholesterol Feeding
Schwenke, D. C. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1928 · Cited by 22 · see citing works
Pathophysiology of Coronary Artery Disease
Jinnouchi, H., Kolodgie, F. D., Romero, M. E., Virmani, R., & Finn, A. V. (2019) · Springer eBooks · doi:10.1007/978-3-030-25249-6_11 · Cited by 21 · see citing works
The gross and histologic appearance and the lipid composition of normal intima and lesions from human coronary arteries and aorta
Panganamala, R. V., Geer, J. C., Sharma, H. M., & Cornwell, D. G. (1974) · Atherosclerosis · doi:10.1016/0021-9150(74)90083-5 · Cited by 21 · see citing works
The dissolution of cholesterol monohydrate crystals in atherosclerotic plaque lipids
North, B. E., Katz, S. S., & SMALL, D. M. (1978) · Atherosclerosis · doi:10.1016/0021-9150(78)90047-3 · Cited by 19 · see citing works
The mass uptake of cholesterol ester from low density lipoproteins by cultured smooth muscle and adventitial cells of human aortas.
Alam, S. S., Solen, K. A., Layman, D. L., Riddle, M. C., & CONNOR, W. E. (1980) · Circulation Research · doi:10.1161/01.res.47.3.374 · Cited by 19 · see citing works
High-resolution proton NMR spectra of human arterial plaque
Zajíček, J., Pearlman, J. D., Merickel, M., Ayers, C. R., Brookeman, J. R., & Brown, M. F. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90386-x · Cited by 18 · see citing works
Compositional mapping of cholesteryl ester droplets in the fatty streaks of human aorta.
Hillman, G. M., & Engelman, D. M. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108524 · Cited by 17 · see citing works
Effects of dietary vitamin E on the growth performance, immunity and digestion of Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂ by physiology, pathology and RNA-seq
Xu, A., Shang-Guan, J., Li, Z., Huang, Z., Shi, S., & Ye, Y. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739752 · Cited by 15 · see citing works
The Control of Lyotropic Liquid-Crystals, Biological and Medical Implications
Dervichian, D. G. (1977) · Molecular crystals and liquid crystals · doi:10.1080/15421407708084468 · Cited by 15 · see citing works
The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis *1Part 2. Studies on “nile blue” cells
Slater, R., & SMITH, E. (1972) · Atherosclerosis · doi:10.1016/0021-9150(72)90037-8 · Cited by 15 · see citing works
Self-citation
CYCLOPHOSPHAMIDE AND INFERTILITY
Feng, P., George, C. R. P., Evans, R. A., Murkin, G. E., Spicer, E. J. F., Thomas, B. S., Hellmann, K., Hassib, H., & Hassib, F. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90819-7 · Cited by 13 · see citing works
Histochemistry and Lipid Profiling Combine for Insights into Aging and Age-Related Maculopathy
Curcio, C. A., Rudolf, M., & Wang, L. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-325-1_15 · Cited by 12 · see citing works
Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance
Hamlat, N., Forcheron, F., Neggazi, S., del Carmine, P., Feugier, P., Bricca, G., Bouguerra, S. A., & Beylot, M. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-64 · Cited by 10 · see citing works
“In addition, foam cells of atheroma plaques accumulate not only cholesterol but also significant amounts of TG (8-10%of total lipid) [ 14-16 ].”
Background
Reduction of Intimal Hyperplasia by Naroparcil, a 4-Methylumbelliferyl β- d -Xyloside Analogue, After Arterial Injury in the Hypercholesterolemic Rabbit
Steg, P. G., Ziol, M., Tahlil, O., Robert, C., Masson, P., Pruneau, D., Bruneval, P., & Bélichard, P. (1995) · Circulation Research · doi:10.1161/01.res.77.5.919 · Cited by 10 · see citing works
Arteriosklerose der Koronararterien und Plaque-Progression
Wohlschlaeger, J., Bertram, S., Theegarten, D., Hager, T., & Baba, H. A. (2015) · Herz · doi:10.1007/s00059-015-4341-0 · Cited by 9 · see citing works
Composition of Plasma and Atheromatous Plaque among Coronary Artery Disease Subjects Consuming Coconut Oil or Sunflower Oil as the Cooking Medium
Palazhy, S., Kamath, P., Rajesh, P., Vaidyanathan, K., Nair, S. K., & Vasudevan, D. M. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720464 · Cited by 8 · see citing works
α-tocopherol and probucol reduce autoantibody titer to MDA-LDL in hypercholesterolemic rabbits
Schwenke, D. C., & Behr, S. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00645-1 · Cited by 8 · see citing works
The Pathology of Ageing [ Abridged ]
Smith, E. B., & Slater, R. S. (1972) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591577206500807 · Cited by 7 · see citing works
Self-citation
Atherosclerotic plaque delamination: Experiments and 2D finite element model to simulate plaque peeling in two strains of transgenic mice
Merei, B., Badel, P., Davis, L. A., Sutton, M. A., Avril, S., & Lessner, S. M. (2016) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.12.001 · Cited by 6 · see citing works
Atherosclerosis, Introduction and Pathophysiology
Yahagi, K., Davis, H. R., Joner, M., & Virmani, R. (2015) · Springer eBooks · doi:10.1007/978-3-319-15961-4_25 · Cited by 6 · see citing works
Roles of lipoproteins in the initiation and development of atherosclerosis
Daugherty, A., & Schonfeld, G. (1985) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(85)90024-5 · Cited by 6 · see citing works
Lipogenesis in arterial wall and vascular smooth muscle cells of Psammomys obesus: Its regulation and abnormalities in diabetes
Hamlat, N., Neggazi, S., Forcheron, F., Bricca, G., Beylot, M., & Bouguerra, S. A. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.01.003 · Cited by 5 · see citing works
Summary of Concepts Concerning the Arterial Wall and Its Atherosclerotic Lesions
SMALL, D. M. (1980) · Springer eBooks · doi:10.1007/978-1-4612-6071-4_102 · Cited by 5 · see citing works
Embelin Elevates Endoplasmic Reticulum Calcium Levels and Blocks the Sterol Regulatory Element‐Binding Protein 2 Mediated Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Improves the Low‐Density Lipoprotein Receptor Mediated Lipid Clearance on Hepatocytes
Chandran, M., Rameshkumar, K. B., Jaleel, A., & Ayyappan, J. P. (2025) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70055 · Cited by 4 · see citing works
Atherogenesis: The Development of Stable and Unstable Plaques
Mori, H., Finn, A. V., Kolodgie, F. D., Davis, H. R., Joner, M., & Virmani, R. (2017) · Springer eBooks · doi:10.1007/978-1-4471-5245-3_2 · Cited by 4 · see citing works
Lack of cytochemically detectable cholesterol in rabbit vena cava endothelial plasma membrane.
Severs, N. J., & Simons, H. L. (1987) · Europe PMC (PubMed Central) · Cited by 4 · see citing works
HDL – Should we be ‘Chasing’ It Now?
Smith, E. B. (1980) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637488009143421 · Cited by 4 · see citing works
Self-citation
Arterial Histochemistry in Relation to Structure, Function and Disease
Adams, C. W. M. (1981) · Springer eBooks · doi:10.1007/978-1-4615-7927-4_1 · Cited by 3 · see citing works
The Emerging Role of Senolysis in Atherosclerosis
Vagena, S., Theocharous, G., Theodorou, A., Pantelis, P., Gravanis, M., Tscheuschner, L., Theodorou, A., Galyfos, G. C., Sigala, F., Lаgopati, N., et al. (2025) · Medicina · doi:10.3390/medicina61122137 · Cited by 2 · see citing works
“In the lipid pool, low-density lipoproteins attach to ECM proteoglycans and are prone to aggregation [26,27].”
Native Coronary Artery and Bypass Graft Atherosclerosis
Yahagi, K., Otsuka, F., Sakakura, K., Joner, M., & Virmani, R. (2014) · Springer eBooks · doi:10.1007/978-3-642-37078-6_15 · Cited by 2 · see citing works
Differential contributions of major lipid components of atheroma to outcome of cerebral atheroembolism. A study in an animal model.
Rail, D., Steiner, T., & Rose, F. C. (1981) · Stroke · doi:10.1161/01.str.12.4.445 · Cited by 2 · see citing works
A Study on Saline Extractable Acid Mucopolysaccharide
IZAWA, M., Kanazawa, T., MURAOKA, H., KANEKO, H., Mori, H., Onodera, K., Metoki, H., SHIMANAKA, Y., KUMAGAI, H., & Kaimori, M. (1983) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.11.4_829 · Cited by 2 · see citing works
Pathological Insights Into the Relationship Between Medial and Intimal Calcification in Lower Extremity Artery Disease
Kato, T., Torii, S., Shiozaki, M., Nakamura, N., Aihara, K., Sato, Y., Matsumoto, Y., Terabe, Y., Iida, O., Tokuda, T., et al. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.102882 · Cited by 1 · see citing works
Vulnerable Plaque
Nakano, M., Kolodgie, F. D., Otsuka, F., Yazdani, S. K., Ladich, E. R., & Virmani, R. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1475-9_9 · Cited by 1 · see citing works
Knowledge fields and emerging trends about extracellular matrix in carotid artery disease from 1990 to 2021: analysis of the scientific literature
Xu, R., Li, T., Li, Z., Kong, W., Wang, T., Zhang, X., Luo, J., Li, W., & Jiao, L. (2023) · European journal of medical research · doi:10.1186/s40001-023-01259-4 · Cited by 1 · see citing works
“Plasma-derived lipoproteins are retained as a result of this interaction [32, 33].”
Background
LIPOPROTEINS AND THE REVERSIBILITY OF ATHEROSCLEROSIS
Smith, E. B., & Slater, R. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90818-5 · Cited by 1 · see citing works
Self-citation
Lipid Deposition in Aorta of Cholesterol-Fed Rabbits
Takashima, T., Kato, H., Yhukou, O. H. T. A., Kuriyama, K., Oogushi, K., Emura, S., HIGUCHI, N., Yoshihara, M., Onohara, S., Ohmori, K., et al. (1988) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.16.1_33 · Cited by 1 · see citing works

The Fatty Acids of Total Lipids and Cholesterol Esters from Normal Plasma and Atheromatous Plaques1
Tuna, N., Reckers, L., & Frantz, I. D. (1958) · Journal of Clinical Investigation · doi:10.1172/jci103705 · Cited by 52 · see citing works
Development of the atherosclerotic core region. Chemical and ultrastructural analysis of microdissected atherosclerotic lesions from human aorta.
Guyton, J. R., & Klemp, K. F. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.8.1305 · Cited by 134 · see citing works
Lipid Fatty Acid Composition of Several Areas of the Aorta in Subjects with Atherosclerosis.
Swell, L., Field, H., Schools, P. E., & Treadwell, C. R. (1960) · Experimental Biology and Medicine · doi:10.3181/00379727-105-26209 · Cited by 29 · see citing works
Relation of Plaque Lipid Composition and Morphology to the Stability of Human Aortic Plaques
Felton, C. V., Crook, D., Davies, M. J., & Oliver, M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1337 · Cited by 276 · see citing works
The composition of cholesterol esters in fatty streaks and atherosclerotic plaques of the human aorta
Künnert, B., & Krug, H. (1971) · Atherosclerosis · doi:10.1016/0021-9150(71)90010-4 · Cited by 21 · see citing works

Authors: SMITH, E., & SLATER, R.
Affiliations: University of Aberdeen (GB)
ORCID: SMITH, E
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 1972-01
Volume: 15
Issue: 1
Pages: 37-56
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/0021-9150(72)90036-6
OpenAlex: W1841536119
Cited by: 115
References: 32
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 1
FWCI: 19.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: atherosclerotic plaque, free cholesterol, oleic acid, fibrous plaque, human aorta
MeSH terms: Adipose Tissue, Aorta, Arteriosclerosis, Cholesterol, Esters, Fatty Acids, Histocytochemistry, Humans, Linoleic Acids, Lipids, Lipoproteins, Microtomy, Oleic Acids, Triglycerides, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis *1Part 1. The lipids in the isolated fractions

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks