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Post-heparin plasma lipoprotein and hepatic lipases

Taskinen, M.R., Glueck, C.J., Kashyap, M.L., Srivastava, L.S., Hynd, B.A., Perisutti, G., Robinson, K., Kinnunen, P.J., Kuusi, T.·1980·Atherosclerosis
DOI 10.1016/0021-9150(80)90010-6
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Abstract

Post-heparin lipoprotein lipase (PH-LPL)-high density lipoprotein cholesterol (HDL-C) interrrelationships were assessed in 9 subjects with documented familial hyperalphalipoproteinemia (FHA) and in 8 controls to focus on potential biochemical etiologies of FHA and relationships of HDL-C to triglyceride hydrolysis and PH-LPL. FHA subjects had mean HDL-C and HDL2-C levels > twice controls; their PH-LPL levels (mean +/- SEM) (3.14 +/- 2.3 mumol FFA/h/ml) were also > twice that of controls (15.0 +/- 1.6) (P 0.1). For all subjects (FHA and controls) PH-LPL was positively correlated with HDL-C (r = 0.79, P 0.1. The amount of apo CII (the primary activator of PH-LPL) in HDL2 was greater in the FHA (mean +/- SEM) (16.1 +/- 2.5 microgram/ml plasma) than in control subjects (4.7 +/- 0.9, P < 0.01). There were strong positive correlations between HDL2 apo CII and both PH-LPL (r = 0.79, P < 0.01) and HDL2-C (r = 0.80, P < 0.01). Apo CII as a percentage of HDL2 protein was higher in FHA than control subjects (mean +/- SEM) (1.2 +/- 0.3% vs 0.5 +/- 0.2%, P < 0.01). Apo CII as a percentage of HDL3 protein was similar in FHA and control subjects. We postulate that increased turnover rate of triglyceride-rich lipoproteins due to high LPL activity may be an important factor leading to the elevation of HDL-C in FHA. The highly significant positive correlation between HDL2-C and PH-LPL provides strong clinical evidence for the theory that HDL2 is formed during the hydrolysis of triglycceride-ric…

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Research works printed but not linked: 23

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  2. Siervogel, 1980, Familial hyperalpha-lipoproteinemia in 26 kindreds, Clin. Genet., 17, 13, 10.1111/j.1399-0004.1980.tb00107.x · DOI
  3. Glueck, 1977, Hyperalpha- and hypobeta-lipoproteinemia in octogenarian kindreds, Atherosclerosis, 27, 387, 10.1016/0021-9150(77)90159-9 · DOI
  4. Glueck, 1976, Longevity syndromes — Familial hypobeta- and familial hyperalpha-lipoproteinemia, J. Lab. Clin. Med., 88, 941
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  6. Mendoza, 1976, Composition of HDL-2 and HDL-3 in familial hyperalphalipoproteinemia, Atherosclerosis, 25, 131, 10.1016/0021-9150(76)90055-1 · DOI
  7. Avogaro, 1977, Familial hyperalpha-lipoproteinemia — Further studies on serum lipoproteins and some serum enzymes, Clin. Chim. Acta, 77, 139, 10.1016/0009-8981(77)90021-3 · DOI
  8. Nikkilä, E.A., Taskinen, M.-R. and Kekki, M., Relation of plasma high density lipoprotein cholesterol to lipoprotein lipase activity in adipose tissue and in skeletal muscle of man, Atherosclerosis, 29 (178) 497. · DOI · Paper page
  9. Taskinen, 1979, Lipoprotein lipase of adipose tissue and of skeletal muscle in insulin deficient human diabetes — Relations to high density and very low density lipoproteins and response to treatment, Diabetologia, 17, 351, 10.1007/BF01236268 · DOI
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  17. Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  18. Chajek, 1978, Very low density lipoprotein — Metabolism of phospholipids, cholesterol and apolipoprotein C in the isolated perfused rat heart, J. Clin. Invest., 61, 1654, 10.1172/JCI109086 · DOI
  19. Huttunen, 1976, Postheparin plasma lipoprotein lipase and hepatic lipase in normal subjects and in patients with hypertriglyceridemia — Correlations to sex, age and various parameters of triglyceride metabolism, Clin. Sci. Mol. Med., 50, 249
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  23. Taskinen, 1979, Effects of high density lipoproteins (HDL) on the in vitro catabolism of very low density lipoproteins (VLDL), Circulation, II-208, 59

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Metadata

Authors
Taskinen, M. R., Glueck, C. J., Kashyap, M. L., Srivastava, L. S., Hynd, B. A., Perisutti, G., Robinson, K., Kinnunen, P. J., & Kuusi, T.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1980-10
Volume
37
Issue
2
Pages
247-256
ISSN
0021-9150
DOI
10.1016/0021-9150(80)90010-6
Cited by
36
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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