Relationship between plasma cholesterol and coronary artery disease in Asians
Abstract
Cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride concentrations were measured in 150 male survivors of first myocardial infarction and in 115 age and ethnic matched healthy controls. The total cholesterol concentration was higher in whites than in respective Asian groups and higher in patients than in controls (P less than 0.001). The ratio of cholesterol to HDL cholesterol was significantly higher in patients (P less than 0.001) and in both ethnic groups was a powerful independent predictor of cases. In Asians, the extent of coronary atheroma assessed by arteriography 2-12 weeks after infarction correlated independently with the total cholesterol concentration (P = 0.03). Thus, in Asian men, the lower level of total cholesterol compared to whites may be misleading. In Asian men the extent of atheroma correlated with the total cholesterol concentration and the relative risk of infarction increased with the ratio of total to HDL cholesterol. At a given level of cholesterol different ethnic groups may be at differing levels of cardiac risk and the cholesterol ratio may be a more appropriate means of inter-ethnic comparison.
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A slightly lower LDL-C cut-off than traditionally defined was used because Indians are known to have lower LDL-C levels than Western populations.
“We used a slightly lower cut-off of LDL-C than traditionally defined (130 mg/dL or 3.37 mmol/L), as Indians are known to have lower LDL-C levels than Western populations [28,29].”
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Kasliwal, R. R., Bansal, M., Gupta, R., Shah, S., Dani, S., Oomman, A., Pai, V., Prasad, G. M., Singhvi, S., Patel, J., et al. (2016) · Nutrition · doi:10.1016/j.nut.2016.01.012 · Cited by 17 · see citing works
- Authors
- Hughes, L. O., Wojciechowski, A. P., & Raftery, E. B.
- Affiliations
- Northwick Park Hospital (GB)
- Corresponding author
- Raftery, E.B.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 83
- Issue
- 1
- Pages
- 15-20
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1997355053
- Cited by
- 46
- References
- 39
- Citations by year
- 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2012: 1
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- serum cholesterol, coronary artery disease, myocardial infarction, HDL cholesterol, triglycerides, TC/HDL-C ratio, coronary atheroma, ethnic differences, Asian men, cardiovascular risk prediction, arteriography
- MeSH terms
- Adult, Aged, Cholesterol, Coronary Disease, England, Europe, Humans, India, Cholesterol, HDL, Male, Middle Aged, Myocardial Infarction, Triglycerides, White People
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