Cited by 23Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismLipid metabolism and disorders

Effects of niceritrol on levels of serum lipids, lipoprotein(a), and fibrinogen in patients with primary hypercholesterolemia

Matsunaga, Akira, Handa, Koichi, Mori, Tsukasa, Moriyama, Kengo, Hidaka, Kazuko, Yuki, Mika, Sasaki, Jun, Arakawa, Kikuo·1992·Atherosclerosis

Abstract

Thirty-three consecutive unselected patients with primary hypercholesterolemia received niceritrol 1.5 g daily for 12 weeks, with the effect of administering divided dose (twice daily (b.i.d.) and three times daily (t.i.d.)) evaluated. The serum concentrations of lipoprotein(a) (Lp(a)), lipids, the major apolipoproteins (apo), cholesteryl ester transfer activity and fibrinogen were determined before and after treatment. The b.i.d. and t.i.d. regimens each significantly reduced the serum levels of total cholesterol and triglyceride. The mean changes in serum lipids and lipoproteins did not differ significantly between the two groups. After 12 weeks of treatment, there was a significant decrease in total plasma cholesterol, triglyceride, low density lipoprotein cholesterol, apo A-II, apo B and fibrinogen and an increase in the high density lipoprotein cholesterol levels. Although the serum level of Lp(a) did not change in every patient, niceritrol significantly reduced the serum Lp(a) level in those with an initially high level of Lp(a) (greater than or equal to 20 mg/dl).

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Crossref · 10.1016/0021-9150(92)90249-g

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Authors
Matsunaga, A., Handa, K., Mori, T., Moriyama, K., Hidaka, K., Yuki, M., Sasaki, J., & Arakawa, K.
Affiliations
Fukuoka University (JP)
Corresponding author
Matsunaga, Akira
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1992-06
Volume
94
Issue
2-3
Pages
241-248
ISSN
0021-9150 (ISSN-L)
OpenAlex
W1981556855
Cited by
23
References
36
Citations by year
2024: 1 · 2023: 1 · 2018: 1 · 2013: 2
FWCI
4.40
Type
journal article
Language
en
Open access
closed
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
  • 情報の科学と技術
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
primary hypercholesterolemia, lipoprotein(a), fibrinogen, serum lipids, apolipoproteins, apolipoprotein A-II, apolipoprotein B, triglycerides, LDL cholesterol, HDL cholesterol, dosing regimen, statins
MeSH terms
Adult, Aged, Apolipoproteins, Apolipoproteins E, Carrier Proteins, Cholesterol, Female, Fibrinogen, Glycoproteins, Humans, Hypercholesterolemia, Lipids, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Niceritrol, Phenotype, Triglycerides, Lipoprotein(a), Cholesterol Ester Transfer Proteins

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