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Cited by 80T-cell and Retrovirus StudiesRNA Research and SplicingHIV Research and Treatment

It is Rous sarcoma virus protein P12 and not P19 that binds tightly to Rous sarcoma virus RNA

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Méric, C., Darlix, J.-L., Spahr, P.-F.·1984·Journal of Molecular Biology
DOI 10.1016/0022-2836(84)90396-6
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Abstract

The interactions between Rous Sarcoma virus (RSV) RNA and the viral proteins in the virus have been analysed by Sen & Todaro (1977) using ultraviolet light irradiation; they showed that the major protein ultraviolet light cross-linked to the viral RNA was P19 as identified by polyacrylamide gel electrophoresis. We report here that it is not viral protein P19 but P12 that binds tightly to RSV RNA upon ultraviolet light irradiation of the virus. Therefore, the binding sites of the viral protein along RSV RNA that we have characterized previously should be correctly attributed now to P12 and not P19.

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  • The NC domain, located within the core, is tightly associated with the retroviral gRNA, protecting it from degradation within the hostile environment of the cell.

    “The NC domain, located within the core, is tightly associated with the retroviral gRNA, protecting it from degradation within the hostile environment of the cell”

    From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Méric et al. 1984

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Authors
Méric, C., Darlix, J.-L., & Spahr, P.-F.
Affiliations
University of Geneva (CH)
ORCID
Darlix, J.-L.
Venue
Journal of Molecular Biology
Publisher
Elsevier BV
Published
1984-03
Volume
173
Issue
4
Pages
531-538
ISSN
0022-2836 (ISSN-L)
DOI
10.1016/0022-2836(84)90396-6
OpenAlex
W2077349154
Cited by
80
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
Rous sarcoma virus, viral RNA, RNA-protein interactions, p19 protein, UV crosslinking, binding sites, retroviral proteins
MeSH terms
Avian Sarcoma Viruses, Binding Sites, Electrophoresis, Polyacrylamide Gel, Phosphoproteins, RNA, Viral, Ultraviolet Rays, Viral Core Proteins, Viral Proteins

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