Subcellular distribution of androgens and oestrogens in target tissue.
Abstract
To study the endogenous concentration of androgens and oestrogens in target tissue, three different methods have been used: (a) measurement of concentration gradient across mammary tumours, (b) long-term infusion of subphysiological amounts of labelled oestrogens and measurement of tissue-plasma gradients in human uterine tissue and (c) measurement of endogenous concentrations in mammary and uterine tissues. In addition to the tissue-plasma gradient, the subcellular distribution was also measured. An improved method is presented for processing the tissue and for the quantitative extraction of steroid hormones from cytosol and nuclear fraction. The data obtained show clearly that steroid hormones have a tissue-plasma gradient that varies from tissue to tissue and from one hormone to another. As steroid hormones exert their influence intracellularly at the site of receptor binding, our findings may have major consequences for the study of hormone-related cancers of the breast and of the uterus.
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An absence of estrogens does not exist in women; comparable levels of E2 are found in breast cancer tissue in pre- and postmenopausal women.
“an absence of estrogens does not exist in women where comparable levels of E 2 are found in breast cancer tissue in pre-and postmenopausal women (272).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [272]
Cites
Jensen, E. V., & DeSombre, E. R. (1973) · Science · doi:10.1126/science.182.4108.126 · Cited by 756 · see citing works
Edery, M., Goussard, J., Dehennin, L., Scholler, R., Reiffsteck, J., & Drosdowsky, M. A. (1981) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(81)90220-6 · Cited by 99 · see citing works
Plasma concentration gradient of steroid hormones across human mammary tumours in vivo
van Landeghem, A. A. J., Poortman, J., Deshpande, N., Martino, L. D., Tarquini, A., Thussen, J. H. H., & Schwarz, F. (1981) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(81)90010-8 · Cited by 66 · see citing works
Self-citationAccumulation of Hormones in Breast Cyst Fluid*
Bradlow, H. L., Schwartz, M. K., Fleisher, M., et al. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-5-778 · Cited by 51 · see citing works
King, R. J. B., Townsend, P. T., SIDDLE, N. C., et al. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90139-x · Cited by 41 · see citing works
Measurement of endogenous subcellular concentration of steroids in tissue
van Landeghem, A. A. J., Poortman, J., Helmond-Agema, A., et al. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90136-5 · Cited by 35 · see citing works
Self-citationWiegerinck, M. A. H. M., Poortman, J., TRUUS, D. H., et al. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-1-76 · Cited by 35 · see citing works
Self-citationSteroids in human myometrium and peripheral blood during the menstrual cycle
Runnebaum, B., Klinga, K., von Holst, T., et al. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90821-9 · Cited by 27 · see citing works
Biogenesis of steroid hormones by human mammary gland in vivo and in vitro
Deshpande, N., CARSON, P., Martino, L. D., et al. (1976) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(76)90106-7 · Cited by 26 · see citing works
Alsbach, G. P. J., Franck, E. R., Poortman, J., et al. (1983) · Contraception · doi:10.1016/s0010-7824(83)80020-1 · Cited by 20 · see citing works
Self-citationAndrogen concentrations in sexual and non-sexual skin as well as in striated muscle in man
Deslypère, J. P., Saved, A., Verdonck, L., et al. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90059-x · Cited by 18 · see citing works
On the Biological Activity of Estrone in vivo
Thijssen, J. H. H., Wiegerinck, M. A. H. M., Mulder, G. J., et al. (2015) · Frontiers of hormone research · doi:10.1159/000401996 · Cited by 5 · see citing works
Self-citation[Steroid hormone content of the breast tissue in breast tumors].
Vallent, K., Fehér, T. D., Bodrogi, L., et al. (1982) · PubMed · Cited by 5 · see citing works
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Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Fat Tissue: A Steroid Reservoir and Site of Steroid Metabolism
DESLYPERE, J. P., VERDONCK, L., & VERMEULEN, A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-3-564 · Cited by 272 · see citing works
Vandenput, L., Labrie, F., Mellström, D., Swanson, C., Knutsson, T., Peeker, R., Ljunggren, Ö., Orwoll, E., Eriksson, A. L., Damber, J.-E., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061018 · Cited by 71 · see citing works
- Authors
- Poortman, J., Thijssen, J. H. H., Landeghem, A. A. J. V., Wiegerinck, M. A. H. M., & Alsbach, G. P. J.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1983-07
- Volume
- 19
- Issue
- 1
- Pages
- 939-945
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2031165352
- Cited by
- 21
- References
- 13
- Citations by year
- 2018: 1 · 2015: 1 · 2014: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- androgens, estrogen, subcellular localization, mammary tumors, uterine tissue, cytosol, nuclear fraction, hormone-receptor binding, breast cancer, uterine cancer
- MeSH terms
- Androgens, Biological Transport, Breast Neoplasms, Endometrium, Estrogens, Female, Humans, Myometrium, Subcellular Fractions, Uterus, Vagina
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