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Cited by 227Hypothalamic control of reproductive hormonesEstrogen and related hormone effectsOvarian function and disorders

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Endocrine characteristics of adolescent menstrual cycles: Impact of early menarche

Vihko, R., Apter, D.·1984·Journal of Steroid Biochemistry
DOI 10.1016/0022-4731(84)90209-7
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Abstract

An initial group of 200 girls, 7-17 years old, was investigated longitudinally 4 times at 1.5-, 1.5- and 5-year intervals. The present study gives information of the impact of early menarche, a risk factor for breast cancer, on some physical and endocrine characteristics in these subjects. The frequency of ovulation depended significantly on both the time since menarche and the age at menarche. Early menarche was associated with early onset of ovulatory cycles. Even in early puberty, before menarche, the subjects who displayed early menarche during follow-up had higher serum FSH and estradiol concentrations than the girls whose menarche took place after the age of 13.0 years. Adrenal androgen secretion (dehydroepiandrosterone) was not influenced by age at menarche but it increased, as expected, on the basis of chronological age. The group with early menarche was characterized by high circulating estradiol concentrations also after menarche, even in the oldest subjects so far studied, 17-25 years of chronological age. At these ages, the differences in the frequencies of ovulatory cycles were disappearing between the groups formed on the basis of age at menarche. The present findings in pre- and postmenarcheal subjects suggest that the increased risk of breast cancer associated with early menarche is created over several years of exposure to high-level estrogen stimulus.

Overview

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Crossref · 10.1016/0022-4731(84)90209-7

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15 of 15 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Korenman, 1980, Oestrogen window hypothesis of the etiology of breast cancer, Lancet, i, 700, 10.1016/S0140-6736(80)92842-1 · DOI

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Metadata

Authors
Vihko, R., & Apter, D.
Affiliations
University of Helsinki (FI)
ORCID
Apter, D.
Venue
Journal of Steroid Biochemistry
Publisher
Elsevier BV
Published
1984-01
Volume
20
Issue
1
Pages
231-236
ISSN
0022-4731 (ISSN-L)
DOI
10.1016/0022-4731(84)90209-7
OpenAlex
W2051445164
Cited by
227
References
15
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Steroid Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
early menarche, age at menarche, ovulation rate, serum FSH, estradiol, dehydroepiandrosterone, adrenal androgen secretion, breast cancer risk, estrogen exposure, puberty, longitudinal cohort
MeSH terms
Adolescent, Age Factors, Body Composition, Child, Dehydroepiandrosterone, Estradiol, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Menarche, Menstruation, Progesterone, Prolactin, Puberty, Precocious, Testosterone

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