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Cited by 54Hemodynamic Monitoring and TherapyBiomedical and Chemical ResearchCardiovascular and exercise physiology

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Low oxygen delivery produced by anemia, hypoxia, and low cardiac output

Cilley, Robert E., Scharenberg, Andrew M., Bongiorno, Phillip F., Guire, Kenneth E., Bartlett, Robert H.·1991·Journal of Surgical Research
DOI 10.1016/0022-4804(91)90145-c
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Abstract

In pentobarbital-anesthetized dogs, oxygen delivery (DO2) was measured by thermodilution cardiac output and cooximeter determined oxygen content, while oxygen consumption (VO2) was measured independently by spirometry. Oxygen delivery was decreased by isovolemic dilutional anemia, breathing hypoxic gas mixtures, or cardiac tamponade to reduce cardiac output. Baseline VO2 (cc/kg/min) for the three groups was 5.9 +/- 0.7 (anemia), 5.4 +/- 0.4 (hypoxia), and 5.6 +/- 0.1 (low C.O.) (NS). A critical level of oxygen delivery (DO2crit) was found at 9-10 cc/kg/min (anemia), 10-11 cc/kg/min (hypoxia), and 9-10 cc/kg/min (low C.O.) (NS.). Below this level, VO2 fell (became supply dependent) and lactic acidosis occurred, regardless of the mechanism of impaired oxygen delivery.

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Crossref · 10.1016/0022-4804(91)90145-c

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13 of 13 references verified0 citation errors · 0 not checkable

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  • If effective fluid resuscitation ensures adequate intravascular volume, oxygen extraction at the tissue level can compensate for the reduction in arterial oxygen content until anemia becomes very severe.

    “If effective fluid resuscitation ensures adequate intravascular volume, oxygen extraction at the tissue level can compensate for the reduction in arterial oxygen content until anemia becomes very severe (81, 82).”

    From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [82]

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Metadata

Authors
Cilley, R. E., Scharenberg, A. M., Bongiorno, P. F., Guire, K. E., & Bartlett, R. H.
Affiliations
University of Michigan (US)
Corresponding author
Cilley, Robert E.
ORCID
Scharenberg, Andrew M.
Venue
Journal of Surgical Research
Publisher
Elsevier BV
Published
1991-11
Volume
51
Issue
5
Pages
425-433
ISSN
0022-4804 (ISSN-L)
DOI
10.1016/0022-4804(91)90145-c
OpenAlex
W2028652466
Cited by
54
References
13
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Surgical Research (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
  • Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
oxygen delivery, anemia, hypoxia, low cardiac output, oxygen consumption, critical oxygen delivery, lactic acidosis, cardiac tamponade, dilutional anemia, hypoxic gas mixture
MeSH terms
Anemia, Animals, Hypoxia, Cardiac Output, Low, Dogs, Lactates, Oxygen Consumption, Thermodilution, Lactic Acid

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