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Cited by 23Multiple Sclerosis Research StudiesAutoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and Disorders

Antibrain antibodies in multiple sclerosis

Ryberg, Björn·1982·Journal of the Neurological Sciences
DOI 10.1016/0022-510x(82)90185-x
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Abstract

IgG antibrain antibodies (ABA) of several specificities can be demonstrated in multiple sclerosis (MS) with the complement fixation technique. This technique seems to discriminate between IgG specifically and non-specifically bound to CNS preparations. Complement-fixing ABA were titrated in paired serum and CSF samples from 87 patients with clinically definite MS, 15 patients with probable MS, 29 patients with other neurological diseases, and 13 "healthy" controls. In addition, sera from 55 non-MS patients were tested. In 40% of the sera and 88% of the CSF samples from patients with clinically definite MS, ABA reacting with human brain homogenate were demonstrated. The corresponding figures for probable MS were 21% and 73%, and for the controls 11% and 6%. Two of 9 sera from patients with the Guillain-Barré syndrome were strongly positive. There was a tendency for higher CSF ABA titres in younger MS patients and in those with an earlier onset of disease. ABA titres in serum and CSF were both correlated with a more malignant course. Irrespective of the mechanism of induction of ABA in MS--an excessive immunogenic stimulation and/or a defective immunoregulation--they are potentially pathogenic in several ways, e.g. (1) by direct antibody action. (2) by interaction with complement, (3) by antibody-dependent K-cell-mediated cytotoxicity, and (4) by interaction with phagocytic cells. Of several correlations among the routine CSF variables in MS, the finding of more pronounced abnormalities in male patients was notable.

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Crossref · 10.1016/0022-510x(82)90185-x

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  • Autoantibodies are associated with other neurological disorders, including schizophrenia and multiple sclerosis.

    “Given the existence of autoantibodies associated with other neurological disorders such as schizophrenia (Henneberg et al, 1994) and multiple sclerosis (Ryberg, 1982)”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Ryberg, 1982

  • Numerous studies have reported circulating anti-brain immunoglobulins in patients with ASD and in related conditions such as multiple sclerosis, schizophrenia, and systemic lupus erythematosus.

    “numerous studies have reported the presence of circulating anti-brain immunoglobulins in patients with ASD, as well as related conditions such as multiple sclerosis (Ryberg, 1982), schizophrenia (Henneberg et al, 1994), and systemic lupus erythematosus (SLE) (Libbey and Fujinami, 2010;Mackay et al, 2015;Suurmond and Diamond, 2015).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Ryberg, 1982

  • Autoantibodies such as those described have been found in patients with other autoimmune disorders, including multiple sclerosis, schizophrenia, and SLE.

    “Autoantibodies, such as those described above, have been found in patients of other autoimmune disorders, including multiple sclerosis (Ryberg, 1982), schizophrenia (Henneberg et al, 1994), and SLE (Libbey and Fujinami, 2010).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Ryberg, 1982

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Authors
Ryberg, B.
Affiliations
Lund University (SE)
Corresponding author
Ryberg, Björn
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
1982-05
Volume
54
Issue
2
Pages
239-261
ISSN
0022-510X (ISSN-L)
DOI
10.1016/0022-510x(82)90185-x
OpenAlex
W1556241727
Cited by
23
References
72
Citations by year
2020: 1 · 2016: 1
FWCI
3.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
multiple sclerosis, anti-brain antibodies, IgG, cerebrospinal fluid, serum, complement fixation, Guillain-Barré syndrome, clinical course, immune regulation, antibody-dependent cellular cytotoxicity, complement system, phagocytes, sex differences
MeSH terms
Adolescent, Adult, Aged, Antibody Specificity, Autoantibodies, Brain, Child, Complement Fixation Tests, Female, Humans, Immunoglobulin G, Male, Middle Aged, Multiple Sclerosis

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