The apo E/apo CIII molar ratio affects removal of cholesterol ester from modified human lipoproteins injected into cebus monkeys
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The removal of postprandial (PP) and postabsorptive (PA) human LDL and HDL cholesterol was examined in cebus monkeys (Cebus albifrons) following in vitro labelling of these lipoproteins by 3H-cholesterol in the presence or absence of DTNB. The removal of LDL cholesteryl ester was 3.5 and 2 times greater than that of HDL in male and female monkeys, respectively. Incubation with DTNB reduced cholesteryl ester removal by 45 and 52% for LDL and HDL, respectively. Cholesteryl ester from PA lipoproteins was removed 80% faster than that PP particles only when plasma was incubated without DTNB. Cholesterol removal from these lipoproteins was positively (r = 0.941) and significantly (P less than 0.001) correlated with the molar apo E/apo CIII ratio. The data suggest that density of lipoproteins was less important than their apoprotein composition in dictating their removal from circulation.
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In cebus monkeys, the rate of removal of cholesteryl ester from HDL was proportional to the apoE to apoC-III ratio of these particles.
“Second, Stephan, Gibson, and Hayes (48) have shown in cebus monkeys that the rate of removal of cholesteryl ester from HDL was proportional to the apoE to apoC-III ratio of these particles.”
From Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans (2003) · cites this paper as [48]
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Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563 · see citing works
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Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans
Cohn, J. S., Batal, R., Tremblay, M., Jacques, H., Veilleux, L., Rodriguez, C., Mamer, O., & Davignon, J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300209-jlr200 · Cited by 35 · see citing works
- Authors
- Stephan, Z. F., Gibson, J. C., & Hayes, K. C.
- Affiliations
- Harvard University (US)
- Brandeis University (US)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1986-04
- Volume
- 38
- Issue
- 15
- Pages
- 1383-1392
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W1969879286
- Cited by
- 3
- References
- 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Life Sciences (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, apolipoprotein C-III, low-density lipoprotein, HDL cholesterol, postprandial lipoproteins, DTNB, lipoprotein clearance, Cebus monkeys, apolipoprotein composition, lipoprotein density
- MeSH terms
- Absorption, Animals, Apolipoproteins C, Apolipoproteins E, Cebus, Cholesterol Esters, Dithionitrobenzoic Acid, Female, Humans, Phosphatidylcholine-Sterol O-Acyltransferase, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Apolipoprotein C-III
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