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Morphine-6-glucuronide, a potent mu agonist
Open accessAbstract
The 3- and the 6-glucuronides of morphine have been examined in binding studies and in vivo. The 3-glucuronide had poor affinity in all binding studies whereas the 6-glucuronide potently labeled mu, but not delta or kappa receptors with affinities similar to morphine. Microinjections of the 3-glucuronide directly into the periaqueductal gray were without effect. The 6-glucuronide, on the other hand, was up to 20-fold more potent than morphine following microinjections in the same region. High doses of the 6-glucuronide produced profound seizure activity. All 6-glucuronide actions were sensitive to the opiate antagonist naloxone.
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Smith, M. T., Watt, J. A., & Cramond, T. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90619-3 · Cited by 337
The impact of opioid-induced hyperalgesia for postoperative pain
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Metabolites of Heroin in Several Different Post-mortem Matrices
Thaulow, C. H., Øiestad, Å. M. L., Rogde, S., Karinen, R., Brochmann, G. W., Andersen, J. M., Høiseth, G., Handal, M., Mørland, J., Arnestad, M., et al. (2018) · Journal of Analytical Toxicology · doi:10.1093/jat/bky002 · Cited by 27
Metadata
- Authors
- Pasternak, G. W., Bodnar, R. J., Clark, J. A., & Inturrisi, C. E.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1987-12
- Volume
- 41
- Issue
- 26
- Pages
- 2845-2849
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2080843499
- Cited by
- 361
- References
- 0
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pasternak, G. W., Bodnar, R. J., Clark, J. A., & Inturrisi, C. E. (1987). Morphine-6-glucuronide, a potent mu agonist. Life Sciences. https://doi.org/10.1016/0024-3205(87)90431-0
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