The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Prevention of exercise-induced muscle membrane damage by oestradiol
Abstract
Exercise can damage the muscle membrane, followed by leakage of certain muscle proteins into the bloodstream. This postexercise response differs for males and females; as an explanation for this difference it has been suggested that oestrogens have a protective effect on the female muscle membrane. We recently developed an animal exercise model in which postexercise damage can be studied in laboratory animals in vivo. A postexercise dimorphism, similar to that in humans, exists in rats and indirect evidence for the involvement of oestradiol (E2) was found. We report here 1) that ovariectomized females show postexercise damage like males, 2) that this response can be prevented by E2-replacement before exercise, and 3) that males, after E2-treatment, no longer show postexercise muscle damage. We therefore conclude that oestradiol indeed plays an important role in protecting skeletal muscle, both in females and in males.
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“Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males (3, 4, 8).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [8]
Citations
Cites
Duval, D., Durant, S., & Homo-Delarche, F. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90008-4 · Cited by 263
Plasma creatine kinase changes after eccentric and concentric contractions
Newham, D. J., Jones, D. A., & Edwards, R. H. T. (1986) · Muscle & Nerve · doi:10.1002/mus.880090109 · Cited by 174
Increased serum creatine kinase after exercise
Shumate, J. B., Brooke, M. H., Carroll, J. E., & Davis, J. E. (1979) · Neurology · doi:10.1212/wnl.29.6.902 · Cited by 127
Effects of exercise on the serum concentrations of FSH, LH, progesterone, and estradiol
Bonen, A., Ling, W., MacIntyre, K. P., Neil, R., McGrail, J. C., & BELCASTRO, A. N. (1979) · European Journal of Applied Physiology · doi:10.1007/bf00421100 · Cited by 126
Exercise-induced muscle protein leakage in the rat
Amelink, G. J., & Bär, P. R. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90142-5 · Cited by 99
Self-citationEstrogen binding proteins in rat skeletal and perineal muscles: in vitro and in vivo studies.
Dionne, F., Lesage, R., Dubé, J., & Tremblay, R. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90156-0 · Cited by 59
Brooke, M. H., Carroll, J. E., Davis, J. E., & Hagberg, J. M. (1979) · Neurology · doi:10.1212/wnl.29.5.636 · Cited by 50
van Steenbrugge, G. J., Groen, M., de Jong, F. H., & Schroeder, F. H. (1984) · The Prostate · doi:10.1002/pros.2990050610 · Cited by 39
Myoglobin in the Very Early Phase of Acute Myocardial Infarction
McComb, J. M., McMaster, E. A., & Jadgey, A. A. (1985) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328502200208 · Cited by 30
Blankenstein, M. A., Broerse, J. J., Vries, J. B. D., den Berg, K. J. V., Knaan, S., & van der Molen, H. J. (1977) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(77)90158-x · Cited by 17
Self-citation
Research works printed but not linked: 2
- Bär, 1986, Muscle Nerve, 9, 200
- Bär, 1985, Neurosci Letters, S22, 288
Cited by
Sorted by citations
Antioxidants: what role do they play in physical activity and health?
Clarkson, P. M., & Thompson, H. S. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.637s · Cited by 687
Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition
Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015) · Physiology · doi:10.1152/physiol.00024.2014 · Cited by 521
The Influence of Estrogen on Skeletal Muscle: Sex Matters
Enns, D. L., & Tiidus, P. M. (2010) · Sports Medicine · doi:10.2165/11319760-000000000-00000 · Cited by 374
Gender differences in muscle inflammation after eccentric exercise
Stupka, N., Lowther, S. A., Chorneyko, K., Bourgeois, J. M., Hogben, C., & Tarnopolsky, M. A. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.6.2325 · Cited by 321
Cellular adaptation to repeated eccentric exercise-induced muscle damage
Stupka, N., Tarnopolsky, M. A., Yardley, N. J., & Phillips, S. M. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1669 · Cited by 279
Metadata
- Authors
- Bär, P. R., Amelink, G. J., Oldenburg, B., & Blankenstein, M. A.
- Affiliations
- Utrecht University (NL)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 42
- Issue
- 26
- Pages
- 2677-2681
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2029497561
- Cited by
- 133
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- exercise-induced muscle damage, estradiol, ovariectomy, sex differences, estrogen replacement therapy, rats
- MeSH terms
- Animals, Aspartate Aminotransferases, Cell Membrane Permeability, Creatine Kinase, Estradiol, Physical Exertion, Female, Male, Ovariectomy, Sarcolemma, Rats
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