Exercise-induced muscle protein leakage in the rat
Abstract
Differences in exercise-induced muscle damage between males and females were studied in an animal model by measuring the serum activities of specific muscle enzymes (creatine kinase and aspartate aminotransferase). It was found that rats showed muscle damage, comparable to that observed in humans after long-term exercise: males were much more affected than females. For example, the CK activity in male rats immediately after exercise was 335% of the resting value, but remained unchanged in females. To test the hypothesis that oestrogens may protect the female muscle membrane, female rats were ovariectomized at different stages of sexual maturity and exercised. A clear effect of this hormonal manipulation was observed: operated animals showed post-exercise CK elevations, depending of the age at the time of ovariectomy. Rats, ovariectomized before reaching sexual maturity, showed more damage than those ovariectomized after reaching sexual maturity.
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Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males.
“Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males (3, 4, 8).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [3]
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Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition
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Obayashi, H., Nezu, Y., Yokota, H., Kiyosawa, N., Mori, K., Maeda, N., Tani, Y., Manabe, S., & Sanbuissho, A. (2011) · The Journal of Toxicological Sciences · doi:10.2131/jts.36.445 · Cited by 26 · see citing works
- Authors
- Amelink, G. J., & Bär, P. R.
- Corresponding author
- Bär, P.R.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 76
- Issue
- 1
- Pages
- 61-68
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1549618298
- Cited by
- 99
- References
- 20
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- exercise-induced muscle damage, sex differences, creatine kinase, aspartate aminotransferase, ovariectomy, estrogen, sexual maturity
- MeSH terms
- Animals, Aspartate Aminotransferases, Creatine Kinase, Estrogens, Physical Exertion, Female, Male, Muscle Proteins, Ovariectomy, Rats, Inbred Strains, Gonadal Steroid Hormones, Sexual Maturation, Rats
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