Cited by 25Renin-Angiotensin System StudiesCoagulation, Bradykinin, Polyphosphates, and AngioedemaEicosanoids and Hypertension Pharmacology

Changes in activity of the renin-angiotensin system of the rat by induction of acute inflammation

Ohtani, Remiko, Ohashi, Yutaka, Muranaga, Kazuko, Itoh, Norio, Okamoto, Hiroshi·1989·Life Sciences

Abstract

Angiotensinogen is the precursor of biologically active peptide angiotensin II and its hepatic synthesis is increased by the induction of acute inflammation. Studies were carried out to know whether the rise in plasma angiotensinogen is actually involved in the activity of the renin-angiotensin system during acute inflammation. The plasma level of angiotensinogen in rats was increased to 2.5 times the normal level 16 h after the induction of acute inflammation by administration of lipopolysaccharide (LPS). The plasma renin concentration (PRC) was decreased to about 40% of the normal level concomitantly with a reduction of plasma renin activity (PRA) at 4 h after LPS administration. In contrast, 16 h after LPS injection, when plasma angiotensinogen showed a high level and PRC had recovered to the normal range, PRA was increased to 1.7 times the normal level. These results indicate that acute inflammation induced by LPS causes a biphasic change in the generation of angiotensin I, i.e., an early decrease depending upon the reduction of PRC and later increase depending upon elevation of the angiotensinogen concentration.

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Crossref · 10.1016/0024-3205(89)90601-2

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Authors
Ohtani, R., Ohashi, Y., Muranaga, K., Itoh, N., & Okamoto, H.
Affiliations
Kobe Gakuin University (JP)
Corresponding author
Okamoto, Hiroshi
Venue
Life Sciences
Publisher
Elsevier BV
Published
1989-01
Volume
44
Issue
3
Pages
237-241
ISSN
0024-3205 (ISSN-L)
OpenAlex
W2030557752
Cited by
25
References
16
Citations by year
2026: 1 · 2023: 1 · 2018: 1 · 2015: 3 · 2014: 2 · 2013: 2
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
renin-angiotensin system, acute inflammation, angiotensinogen, plasma renin activity, plasma renin concentration, lipopolysaccharide, angiotensin I, biphasic response, rats
MeSH terms
Acute Disease, Angiotensin I, Angiotensinogen, Animals, Inflammation, Lipopolysaccharides, Male, Rats, Inbred F344, Renin, Renin-Angiotensin System, Rats

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