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Cited by 45Neurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormonesSexual function and dysfunction studies

The DOI matches its Crossref record.

Dose dependent D2 effects on genital reflexes after MPOA injections of quinelorane and apomorphine

Bazzett, T.J., Eaton, R.C., Thompson, J.T., Markowski, V.P., Lumley, L.A., Hull, E.M.·1991·Life Sciences
DOI 10.1016/0024-3205(91)90267-f
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Abstract

This study investigated the effects on genital reflexes of unilateral MPOA injections of 0.1, 1, 3, and 10 micrograms of the D2 agonist quinelorane (LY-163502), and of 3 micrograms quinelorane administered together with 3 micrograms of the D1 antagonist SCH-23390. In addition, the effects of an MPOA injection of 10 micrograms apomorphine were tested. All but the lowest dose of quinelorane significantly decreased the latency to the first reflex. The 3 and 10 micrograms doses of quinelorane, and the combination of quinelorane and SCH-23390, decreased the total number of reflexes. In addition, 10 micrograms quinelorane increased the number of seminal emissions. 10 micrograms apomorphine, like 10 micrograms quinelorane, decreased the latency to the first reflex and increased the number of seminal emissions, but did not decrease the numbers of erections or penile movements. The ratio of D1/D2 activity may influence the number of erections displayed during ex copula testing.

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Metadata

Authors
Bazzett, T. J., Eaton, R. C., Thompson, J. T., Markowski, V. P., Lumley, L. A., & Hull, E. M.
Affiliations
University at Buffalo, State University of New York (US)
Corresponding author
Hull, E.M.
ORCID
Venue
Life Sciences
Publisher
Elsevier BV
Published
1991-01
Volume
48
Issue
24
Pages
2309-2315
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/0024-3205(91)90267-f
OpenAlex
W2114651578
Cited by
45
References
0
Citations by year
2025: 1 · 2022: 1 · 2019: 3 · 2016: 1 · 2014: 2
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Eli Lilly and Company
  • National Institutes of Health
  • National Institute of Mental Health (MH40826, R01MH040826)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords
dopamine D2 receptor, dopamine D1 receptor, quinelorane, apomorphine, medial preoptic area, seminal emission, erection, dopamine agonists, dopamine antagonists
MeSH terms
Animals, Apomorphine, Benzazepines, Male, Penile Erection, Penis, Preoptic Area, Quinolines, Receptors, Dopamine, Reflex, Receptors, Dopamine D2, Rats

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