Microinjection of the dopamine antagonist cis-flupenthixol into the MPOA impairs copulation, penile reflexes and sexual motivation in male rats
Abstract
Microinjection of the dopamine antagonist cis-flupenthixol into the medial preoptic area was previously shown to impair male rat copulatory behavior. The present experiments provide further evidence of cis-flupenthixol's inhibitory effects on male sexual behavior. Following microinjections of moderate to high doses of cis-flupenthixol, males exhibited slower copulatory rates and fewer ejaculations in copula, fewer ex copula erections and penile movements, and reduced sexual motivation in an X-maze. Locomotion in the X-maze was not significantly affected. Microinjections of the inactive isomer trans-flupenthixol produced no change in any behavioral measure, indicating that cis-flupenthixol's effects were receptor mediated. We suggest that dopamine receptors in the MPOA influence copulation primarily by regulating reflexive and motivational factors, but not locomotion.
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All of these procedures produce structural or functional changes in the erectile system.
“All of these procedures produce structural or functional changes in the erectile system (Hull et al. 1992; Monaghan et al. 1993; Warner et al. 1991).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Warner et al. 1991
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Self-citationPfaus, J. G., Kippin, T. E., Coria-Avila, G. A., Gelez, H., Afonso, V. M., Ismail, N., & Parada, M. (2012) · Archives of Sexual Behavior · doi:10.1007/s10508-012-9935-5 · Cited by 215 · see citing works
Sexual behavior increases c-fos expression in the forebrain of the male rat
Robertson, G. S., Pfaus, J. G., Atkinson, L. J., Matsumura, H., Phillips, A. G., & Fibiger, H. C. (1991) · Brain Research · doi:10.1016/0006-8993(91)91477-i · Cited by 169 · see citing works
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“Of course, it has already been shown that dopamine neurotransmission in the MPOA plays a role in sexual motivation in male rats (Warner et al., 1991).”
Colbert, N. K. W., Pelletier, N. C., Cote, J. M., Concannon, J. B., Jurdak, N. A., Minott, S. B., & Markowski, V. P. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7509 · Cited by 60 · see citing works
“Occupational exposure to stilbene has also been associated with an increase in self-reported impotence and decreased libido (Quinn et al. 1990; Whelan et al. 1996).”
BackgroundSelf-citation
- Authors
- Warner, R. K., Thompson, J. T., Markowski, V. P., Loucks, J. A., Bazzett, T. J., Eaton, R. C., & Hull, E. M.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Hull, Elaine M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 540
- Issue
- 1-2
- Pages
- 177-182
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2121727894
- Cited by
- 115
- References
- 0
- Citations by year
- 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH40826, R01MH040826)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- cis-flupenthixol, dopamine antagonists, medial preoptic area, male sexual behavior, copulation, penile reflexes, sexual motivation, dopamine receptors, microinjection, rats
- MeSH terms
- Animals, Copulation, Female, Flupenthixol, Learning, Male, Microinjections, Motivation, Penis, Preoptic Area, Reference Values, Reflex, Sexual Behavior, Animal, Rats
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