The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Adrenal glands of mouse and rat do not synthesize androgens
Abstract
Human adrenal glands produce considerable amounts of the C-19 steroids dehydroepiandrosterone (DHEA) and androstenedione. To investigate the capability of rodent adrenals to produce these steroids, cell suspensions of mouse and rat adrenal glands were incubated in the absence and presence of adrenocorticotropic hormone (ACTH). Corticosterone levels in the incubation medium increased dramatically in the presence of ACTH, but no significant amounts of 17-hydroxyprogesterone or androstenedione could be detected. This indicates that the adrenals of rat and mouse lack the enzyme 17 alpha-hydroxylase. Absence of plasma cortisol in the presence of high levels of corticosterone confirmed these data. Plasma levels of androstenedione were significantly decreased in castrated male rats as compared to levels observed in intact males, showing the contribution of the testes to the plasma content of androstenedione. Very low levels of androstenedione were observed in female, male and castrated male mice. Plasma concentrations of DHEA were not detectable in intact and castrated male mice and rats. It is concluded that rat and mouse lack the enzyme necessary to synthesize adrenal C-19 steroids and that the adrenals in these animals, therefore, do not contribute to plasma levels of androstenedione and DHEA.
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“Therefore, unlike humans, mouse and rat adrenals do not produce significant levels of androgen precursors (van Weerden et al., 1992) which can serve as substrates for intracrine action and are therefore not valid models for studies of human androgen intracrinology.”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as van Weerden et al., 1992
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Metadata
- Authors
- van Weerden, W. M., Bierings, H. G., Van Steenbrugge, G. J., De Jong, F. H., & Schröder, F. H.
- Affiliations
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 50
- Issue
- 12
- Pages
- 857-861
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2041880296
- Cited by
- 260
- References
- 23
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 18 · 2017: 9 · 2016: 15 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- adrenal gland, androgen production, C19 steroids, dehydroepiandrosterone, androstenedione, 17α-hydroxylase, ACTH, corticosterone, 17-hydroxyprogesterone, testicular androgen production, castration
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Glands, Adrenal Hyperplasia, Congenital, Adrenocorticotropic Hormone, Androgens, Animals, Castration, Female, Hydroxyprogesterones, Male, Mice, Inbred BALB C, Progesterone, Rats, Inbred Strains, Testis, 17-alpha-Hydroxyprogesterone, Mice, Rats
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